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Items: 1 to 20 of 222

1.

Role of Smad4 (DPC4) inactivation in human cancer.

Miyaki M, Kuroki T.

Biochem Biophys Res Commun. 2003 Jul 11;306(4):799-804. Review.

PMID:
12821112
3.

Mutations in the SMAD4/DPC4 gene in juvenile polyposis.

Howe JR, Roth S, Ringold JC, Summers RW, Järvinen HJ, Sistonen P, Tomlinson IP, Houlston RS, Bevan S, Mitros FA, Stone EM, Aaltonen LA.

Science. 1998 May 15;280(5366):1086-8.

4.

SMAD4 mutations in colorectal cancer probably occur before chromosomal instability, but after divergence of the microsatellite instability pathway.

Woodford-Richens KL, Rowan AJ, Gorman P, Halford S, Bicknell DC, Wasan HS, Roylance RR, Bodmer WF, Tomlinson IP.

Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9719-23. Epub 2001 Jul 31.

5.

Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes.

Takaku K, Oshima M, Miyoshi H, Matsui M, Seldin MF, Taketo MM.

Cell. 1998 Mar 6;92(5):645-56.

6.

Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis.

Miyaki M, Iijima T, Konishi M, Sakai K, Ishii A, Yasuno M, Hishima T, Koike M, Shitara N, Iwama T, Utsunomiya J, Kuroki T, Mori T.

Oncogene. 1999 May 20;18(20):3098-103.

7.

No SMAD4 hypermethylation in colorectal cancer.

Roth S, Laiho P, Salovaara R, Launonen V, Aaltonen LA.

Br J Cancer. 2000 Oct;83(8):1015-9.

8.

Gastrointestinal tumorigenesis in Smad4 (Dpc4) mutant mice.

Taketo MM, Takaku K.

Hum Cell. 2000 Sep;13(3):85-95. Review.

PMID:
11197776
9.

Serrated adenomas and mixed polyposis caused by a splice acceptor deletion in the mouse Smad4 gene.

Hohenstein P, Molenaar L, Elsinga J, Morreau H, van der Klift H, Struijk A, Jagmohan-Changur S, Smits R, van Kranen H, van Ommen GJ, Cornelisse C, Devilee P, Fodde R.

Genes Chromosomes Cancer. 2003 Mar;36(3):273-82.

PMID:
12557227
10.

Homozygous deletions inactivate DCC, but not MADH4/DPC4/SMAD4, in a subset of pancreatic and biliary cancers.

Hilgers W, Song JJ, Haye M, Hruban RR, Kern SE, Fearon ER.

Genes Chromosomes Cancer. 2000 Apr;27(4):353-7.

PMID:
10719364
11.

No effects of Smad2 (madh2) null mutation on malignant progression of intestinal polyps in Apc(delta716) knockout mice.

Takaku K, Wrana JL, Robertson EJ, Taketo MM.

Cancer Res. 2002 Aug 15;62(16):4558-61.

12.

Screening SMAD1, SMAD2, SMAD3, and SMAD5 for germline mutations in juvenile polyposis syndrome.

Bevan S, Woodford-Richens K, Rozen P, Eng C, Young J, Dunlop M, Neale K, Phillips R, Markie D, Rodriguez-Bigas M, Leggett B, Sheridan E, Hodgson S, Iwama T, Eccles D, Bodmer W, Houlston R, Tomlinson I.

Gut. 1999 Sep;45(3):406-8.

13.

[Alterations of DPC4/SMAD4/MADH4 gene detected in paraffin-embedded tissues of human pancreatic carcinomas].

Gu LJ, Chen J, Liu TH, Cui QC, Lu ZH, Li L, Gao J.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2002 Apr;24(2):165-9. Chinese.

PMID:
12905795
14.

Status of the DPC4 tumor suppressor gene in sporadic colon adenocarcinoma of Croatian patients: identification of a novel somatic mutation.

Popović Hadzija M, Radosevic S, Kovacević D, Lukac J, Hadzija M, Spaventi R, Pavelić K, Kapitanović S.

Mutat Res. 2004 Apr 14;548(1-2):61-73.

PMID:
15063137
15.

Mutations in DPC4 (SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases.

Houlston R, Bevan S, Williams A, Young J, Dunlop M, Rozen P, Eng C, Markie D, Woodford-Richens K, Rodriguez-Bigas MA, Leggett B, Neale K, Phillips R, Sheridan E, Hodgson S, Iwama T, Eccles D, Bodmer W, Tomlinson I.

Hum Mol Genet. 1998 Nov;7(12):1907-12.

PMID:
9811934
16.

Gastro-intestinal tumorigenesis in Smad4 mutant mice.

Taketo MM, Takaku K.

Cytokine Growth Factor Rev. 2000 Mar-Jun;11(1-2):147-57. Review.

PMID:
10708962
17.

Molecular analyses of the 15q and 18q SMAD genes in pancreatic cancer.

Jonson T, Gorunova L, Dawiskiba S, Andrén-Sandberg A, Stenman G, ten Dijke P, Johansson B, Höglund M.

Genes Chromosomes Cancer. 1999 Jan;24(1):62-71.

PMID:
9892110
18.

Analysis of SMAD4/DPC4 gene alterations in multiploid colorectal carcinomas.

Ando T, Sugai T, Habano W, Jiao YF, Suzuki K.

J Gastroenterol. 2005 Jul;40(7):708-15.

PMID:
16082587
19.

Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice.

Takaku K, Miyoshi H, Matsunaga A, Oshima M, Sasaki N, Taketo MM.

Cancer Res. 1999 Dec 15;59(24):6113-7.

20.

Combined copy status of 18q21 genes in colorectal cancer shows frequent retention of SMAD7.

Boulay JL, Mild G, Reuter J, Lagrange M, Terracciano L, Lowy A, Laffer U, Orth B, Metzger U, Stamm B, Martinoli S, Herrmann R, Rochlitz C.

Genes Chromosomes Cancer. 2001 Jul;31(3):240-7.

PMID:
11391794

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