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Items: 1 to 20 of 68

1.

Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation.

Schwarz JK, Lovly CM, Piwnica-Worms H.

Mol Cancer Res. 2003 Jun;1(8):598-609.

2.

Exploring the intramolecular phosphorylation sites in human Chk2.

Olsen BB, Larsen MR, Boldyreff B, Niefind K, Issinger OG.

Mutat Res. 2008 Nov 10;646(1-2):50-9. doi: 10.1016/j.mrfmmm.2008.09.002. Epub 2008 Sep 11.

PMID:
18812180
3.

Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase.

Cai Z, Chehab NH, Pavletich NP.

Mol Cell. 2009 Sep 24;35(6):818-29. doi: 10.1016/j.molcel.2009.09.007.

4.

Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage.

Bahassi el M, Myer DL, McKenney RJ, Hennigan RF, Stambrook PJ.

Mutat Res. 2006 Apr 11;596(1-2):166-76. Epub 2006 Feb 14.

PMID:
16481012
5.

Autophosphorylated residues involved in the regulation of human chk2 in vitro.

Gabant G, Lorphelin A, Nozerand N, Marchetti C, Bellanger L, Dedieu A, Quéméneur E, Alpha-Bazin B.

J Mol Biol. 2008 Jul 11;380(3):489-503. doi: 10.1016/j.jmb.2008.04.053. Epub 2008 May 1.

PMID:
18538787
6.

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro.

Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ.

Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10389-94.

8.

Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis.

Wu X, Chen J.

J Biol Chem. 2003 Sep 19;278(38):36163-8. Epub 2003 Jul 9.

9.

Mechanism of dual specificity kinase activity of DYRK1A.

Walte A, Rüben K, Birner-Gruenberger R, Preisinger C, Bamberg-Lemper S, Hilz N, Bracher F, Becker W.

FEBS J. 2013 Sep;280(18):4495-511. doi: 10.1111/febs.12411. Epub 2013 Jul 22.

10.

Mass spectrometry and site-directed mutagenesis identify several autophosphorylated residues required for the activity of PrkC, a Ser/Thr kinase from Bacillus subtilis.

Madec E, Stensballe A, Kjellström S, Cladière L, Obuchowski M, Jensen ON, Séror SJ.

J Mol Biol. 2003 Jul 11;330(3):459-72.

PMID:
12842463
11.
12.
13.

Chk2 activation and phosphorylation-dependent oligomerization.

Xu X, Tsvetkov LM, Stern DF.

Mol Cell Biol. 2002 Jun;22(12):4419-32.

14.
16.

Threonines 2638/2647 in DNA-PK are essential for cellular resistance to ionizing radiation.

Soubeyrand S, Pope L, Pakuts B, Haché RJ.

Cancer Res. 2003 Mar 15;63(6):1198-201.

17.

Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.

Melchionna R, Chen XB, Blasina A, McGowan CH.

Nat Cell Biol. 2000 Oct;2(10):762-5.

PMID:
11025670
18.

Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379.

Lovly CM, Yan L, Ryan CE, Takada S, Piwnica-Worms H.

Mol Cell Biol. 2008 Oct;28(19):5874-85. doi: 10.1128/MCB.00821-08. Epub 2008 Jul 21.

19.
20.

Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity.

Zhou BB, Chaturvedi P, Spring K, Scott SP, Johanson RA, Mishra R, Mattern MR, Winkler JD, Khanna KK.

J Biol Chem. 2000 Apr 7;275(14):10342-8.

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