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Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.

Zou L, Elledge SJ.

Science. 2003 Jun 6;300(5625):1542-8.


Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling.

Choi JH, Lindsey-Boltz LA, Kemp M, Mason AC, Wold MS, Sancar A.

Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13660-5. doi: 10.1073/pnas.1007856107.


Function of a conserved checkpoint recruitment domain in ATRIP proteins.

Ball HL, Ehrhardt MR, Mordes DA, Glick GG, Chazin WJ, Cortez D.

Mol Cell Biol. 2007 May;27(9):3367-77.


ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA.

Zhang H, Head PE, Daddacha W, Park SH, Li X, Pan Y, Madden MZ, Duong DM, Xie M, Yu B, Warren MD, Liu EA, Dhere VR, Li C, Pradilla I, Torres MA, Wang Y, Dynan WS, Doetsch PW, Deng X, Seyfried NT, Gius D, Yu DS.

Cell Rep. 2016 Feb 16;14(6):1435-47. doi: 10.1016/j.celrep.2016.01.018.


ATRIP associates with replication protein A-coated ssDNA through multiple interactions.

Namiki Y, Zou L.

Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):580-5.


ATR autophosphorylation as a molecular switch for checkpoint activation.

Liu S, Shiotani B, Lahiri M, Maréchal A, Tse A, Leung CC, Glover JN, Yang XH, Zou L.

Mol Cell. 2011 Jul 22;43(2):192-202. doi: 10.1016/j.molcel.2011.06.019.


Function of the ATR N-terminal domain revealed by an ATM/ATR chimera.

Chen X, Zhao R, Glick GG, Cortez D.

Exp Cell Res. 2007 May 1;313(8):1667-74.


PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.

Maréchal A, Li JM, Ji XY, Wu CS, Yazinski SA, Nguyen HD, Liu S, Jiménez AE, Jin J, Zou L.

Mol Cell. 2014 Jan 23;53(2):235-46. doi: 10.1016/j.molcel.2013.11.002.


Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway.

Nakada D, Hirano Y, Sugimoto K.

Mol Cell Biol. 2004 Nov;24(22):10016-25.


ATR and ATRIP are recruited to herpes simplex virus type 1 replication compartments even though ATR signaling is disabled.

Mohni KN, Livingston CM, Cortez D, Weller SK.

J Virol. 2010 Dec;84(23):12152-64. doi: 10.1128/JVI.01643-10.


Recruitment of ATR-ATRIP, Rad17, and 9-1-1 complexes to DNA damage.

Yang XH, Zou L.

Methods Enzymol. 2006;409:118-31.


A novel protein activity mediates DNA binding of an ATR-ATRIP complex.

Bomgarden RD, Yean D, Yee MC, Cimprich KA.

J Biol Chem. 2004 Apr 2;279(14):13346-53.


DNA stimulates Mec1-mediated phosphorylation of replication protein A.

Bartrand AJ, Iyasu D, Brush GS.

J Biol Chem. 2004 Jun 18;279(25):26762-7.


The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling.

Xu X, Vaithiyalingam S, Glick GG, Mordes DA, Chazin WJ, Cortez D.

Mol Cell Biol. 2008 Dec;28(24):7345-53. doi: 10.1128/MCB.01079-08.


Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase eta on ATR checkpoint signaling.

Bomgarden RD, Lupardus PJ, Soni DV, Yee MC, Ford JM, Cimprich KA.

EMBO J. 2006 Jun 7;25(11):2605-14. Erratum in: EMBO J. 2006 Oct 18;25(20):5036.


Role of the C terminus of Mec1 checkpoint kinase in its localization to sites of DNA damage.

Nakada D, Hirano Y, Tanaka Y, Sugimoto K.

Mol Biol Cell. 2005 Nov;16(11):5227-35.


APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress.

Willis J, Patel Y, Lentz BL, Yan S.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10592-7. doi: 10.1073/pnas.1301445110.


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