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Items: 1 to 20 of 117

1.

Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity.

Yamanaka T, Horikoshi Y, Sugiyama Y, Ishiyama C, Suzuki A, Hirose T, Iwamatsu A, Shinohara A, Ohno S.

Curr Biol. 2003 Apr 29;13(9):734-43.

2.

Lgl mediates apical domain disassembly by suppressing the PAR-3-aPKC-PAR-6 complex to orient apical membrane polarity.

Yamanaka T, Horikoshi Y, Izumi N, Suzuki A, Mizuno K, Ohno S.

J Cell Sci. 2006 May 15;119(Pt 10):2107-18. Epub 2006 Apr 25.

3.

Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures.

Suzuki A, Yamanaka T, Hirose T, Manabe N, Mizuno K, Shimizu M, Akimoto K, Izumi Y, Ohnishi T, Ohno S.

J Cell Biol. 2001 Mar 19;152(6):1183-96.

4.

aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity.

Suzuki A, Hirata M, Kamimura K, Maniwa R, Yamanaka T, Mizuno K, Kishikawa M, Hirose H, Amano Y, Izumi N, Miwa Y, Ohno S.

Curr Biol. 2004 Aug 24;14(16):1425-35.

5.
6.

Involvement of ASIP/PAR-3 in the promotion of epithelial tight junction formation.

Hirose T, Izumi Y, Nagashima Y, Tamai-Nagai Y, Kurihara H, Sakai T, Suzuki Y, Yamanaka T, Suzuki A, Mizuno K, Ohno S.

J Cell Sci. 2002 Jun 15;115(Pt 12):2485-95.

7.

A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl.

Plant PJ, Fawcett JP, Lin DC, Holdorf AD, Binns K, Kulkarni S, Pawson T.

Nat Cell Biol. 2003 Apr;5(4):301-8.

PMID:
12629547
8.

PAR-6 regulates aPKC activity in a novel way and mediates cell-cell contact-induced formation of the epithelial junctional complex.

Yamanaka T, Horikoshi Y, Suzuki A, Sugiyama Y, Kitamura K, Maniwa R, Nagai Y, Yamashita A, Hirose T, Ishikawa H, Ohno S.

Genes Cells. 2001 Aug;6(8):721-31.

9.

Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms.

Grzeschik NA, Parsons LM, Allott ML, Harvey KF, Richardson HE.

Curr Biol. 2010 Apr 13;20(7):573-81. doi: 10.1016/j.cub.2010.01.055. Epub 2010 Apr 1.

10.

aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization.

Suzuki A, Ishiyama C, Hashiba K, Shimizu M, Ebnet K, Ohno S.

J Cell Sci. 2002 Sep 15;115(Pt 18):3565-73.

11.

Protein phosphatase 2A negatively regulates aPKC signaling by modulating phosphorylation of Par-6 in Drosophila neuroblast asymmetric divisions.

Ogawa H, Ohta N, Moon W, Matsuzaki F.

J Cell Sci. 2009 Sep 15;122(Pt 18):3242-9. doi: 10.1242/jcs.050955. Epub 2009 Aug 18.

12.

Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells.

Horikoshi Y, Suzuki A, Yamanaka T, Sasaki K, Mizuno K, Sawada H, Yonemura S, Ohno S.

J Cell Sci. 2009 May 15;122(Pt 10):1595-606. doi: 10.1242/jcs.043174. Epub 2009 Apr 28.

13.

Slmb antagonises the aPKC/Par-6 complex to control oocyte and epithelial polarity.

Morais-de-Sá E, Mukherjee A, Lowe N, St Johnston D.

Development. 2014 Aug;141(15):2984-92. doi: 10.1242/dev.109827.

14.

Meiotic maturation induces animal-vegetal asymmetric distribution of aPKC and ASIP/PAR-3 in Xenopus oocytes.

Nakaya M, Fukui A, Izumi Y, Akimoto K, Asashima M, Ohno S.

Development. 2000 Dec;127(23):5021-31.

15.

An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3.

Izumi Y, Hirose T, Tamai Y, Hirai S, Nagashima Y, Fujimoto T, Tabuse Y, Kemphues KJ, Ohno S.

J Cell Biol. 1998 Oct 5;143(1):95-106.

16.

Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity.

Hurov JB, Watkins JL, Piwnica-Worms H.

Curr Biol. 2004 Apr 20;14(8):736-41.

17.

aPKC phosphorylates Miranda to polarize fate determinants during neuroblast asymmetric cell division.

Atwood SX, Prehoda KE.

Curr Biol. 2009 May 12;19(9):723-9. doi: 10.1016/j.cub.2009.03.056. Epub 2009 Apr 16.

18.

Lgl and its phosphorylation by aPKC regulate oocyte polarity formation in Drosophila.

Tian AG, Deng WM.

Development. 2008 Feb;135(3):463-71. Epub 2007 Dec 19.

19.

The Cdc42/Par6/aPKC polarity complex regulates apoptosis-induced compensatory proliferation in epithelia.

Warner SJ, Yashiro H, Longmore GD.

Curr Biol. 2010 Apr 27;20(8):677-86. doi: 10.1016/j.cub.2010.03.025. Epub 2010 Apr 8.

20.

Par-aPKC-dependent and -independent mechanisms cooperatively control cell polarity, Hippo signaling, and cell positioning in 16-cell stage mouse embryos.

Hirate Y, Hirahara S, Inoue K, Kiyonari H, Niwa H, Sasaki H.

Dev Growth Differ. 2015 Oct;57(8):544-56. doi: 10.1111/dgd.12235. Epub 2015 Oct 9.

PMID:
26450797

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