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Functional similarities and differences between Candida albicans Cdr1p and Cdr2p transporters.

Gauthier C, Weber S, Alarco AM, Alqawi O, Daoud R, Georges E, Raymond M.

Antimicrob Agents Chemother. 2003 May;47(5):1543-54.


Relative contributions of the Candida albicans ABC transporters Cdr1p and Cdr2p to clinical azole resistance.

Tsao S, Rahkhoodaee F, Raymond M.

Antimicrob Agents Chemother. 2009 Apr;53(4):1344-52. doi: 10.1128/AAC.00926-08. Epub 2009 Feb 17.


ABC transporter Cdr1p contributes more than Cdr2p does to fluconazole efflux in fluconazole-resistant Candida albicans clinical isolates.

Holmes AR, Lin YH, Niimi K, Lamping E, Keniya M, Niimi M, Tanabe K, Monk BC, Cannon RD.

Antimicrob Agents Chemother. 2008 Nov;52(11):3851-62. doi: 10.1128/AAC.00463-08. Epub 2008 Aug 18.


The Candida albicans Cdr2p ATP-binding cassette (ABC) transporter confers resistance to caspofungin.

Schuetzer-Muehlbauer M, Willinger B, Krapf G, Enzinger S, Presterl E, Kuchler K.

Mol Microbiol. 2003 Apr;48(1):225-35.


ABC transporters Cdr1p, Cdr2p and Cdr3p of a human pathogen Candida albicans are general phospholipid translocators.

Smriti, Krishnamurthy S, Dixit BL, Gupta CM, Milewski S, Prasad R.

Yeast. 2002 Mar 15;19(4):303-18.


Heterozygosity and functional allelic variation in the Candida albicans efflux pump genes CDR1 and CDR2.

Holmes AR, Tsao S, Ong SW, Lamping E, Niimi K, Monk BC, Niimi M, Kaneko A, Holland BR, Schmid J, Cannon RD.

Mol Microbiol. 2006 Oct;62(1):170-86. Epub 2006 Aug 30.


Reversal of antifungal resistance mediated by ABC efflux pumps from Candida albicans functionally expressed in yeast.

Schuetzer-Muehlbauer M, Willinger B, Egner R, Ecker G, Kuchler K.

Int J Antimicrob Agents. 2003 Sep;22(3):291-300.


Chimeras of Candida albicans Cdr1p and Cdr2p reveal features of pleiotropic drug resistance transporter structure and function.

Tanabe K, Lamping E, Nagi M, Okawada A, Holmes AR, Miyazaki Y, Cannon RD, Monk BC, Niimi M.

Mol Microbiol. 2011 Oct;82(2):416-33. doi: 10.1111/j.1365-2958.2011.07820.x. Epub 2011 Sep 19.


Rationally designed transmembrane peptide mimics of the multidrug transporter protein Cdr1 act as antagonists to selectively block drug efflux and chemosensitize azole-resistant clinical isolates of Candida albicans.

Maurya IK, Thota CK, Verma SD, Sharma J, Rawal MK, Ravikumar B, Sen S, Chauhan N, Lynn AM, Chauhan VS, Prasad R.

J Biol Chem. 2013 Jun 7;288(23):16775-87. doi: 10.1074/jbc.M113.467159. Epub 2013 Apr 16.


Fluconazole transport into Candida albicans secretory vesicles by the membrane proteins Cdr1p, Cdr2p, and Mdr1p.

Basso LR Jr, Gast CE, Mao Y, Wong B.

Eukaryot Cell. 2010 Jun;9(6):960-70. doi: 10.1128/EC.00355-09. Epub 2010 Mar 26.


Enhanced susceptibility to antifungal oligopeptides in yeast strains overexpressing ABC multidrug efflux pumps.

Wakiec R, Gabriel I, Prasad R, Becker JM, Payne JW, Milewski S.

Antimicrob Agents Chemother. 2008 Nov;52(11):4057-63. doi: 10.1128/AAC.01648-07. Epub 2008 Sep 15.


Overexpression of Candida albicans CDR1, CDR2, or MDR1 does not produce significant changes in echinocandin susceptibility.

Niimi K, Maki K, Ikeda F, Holmes AR, Lamping E, Niimi M, Monk BC, Cannon RD.

Antimicrob Agents Chemother. 2006 Apr;50(4):1148-55.


Regulated overexpression of CDR1 in Candida albicans confers multidrug resistance.

Niimi M, Niimi K, Takano Y, Holmes AR, Fischer FJ, Uehara Y, Cannon RD.

J Antimicrob Chemother. 2004 Dec;54(6):999-1006. Epub 2004 Oct 14.


Functional expression of Candida albicans drug efflux pump Cdr1p in a Saccharomyces cerevisiae strain deficient in membrane transporters.

Nakamura K, Niimi M, Niimi K, Holmes AR, Yates JE, Decottignies A, Monk BC, Goffeau A, Cannon RD.

Antimicrob Agents Chemother. 2001 Dec;45(12):3366-74.


Functional characterization of Candida albicans ABC transporter Cdr1p.

Shukla S, Saini P, Smriti, Jha S, Ambudkar SV, Prasad R.

Eukaryot Cell. 2003 Dec;2(6):1361-75.


Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.

Sanglard D, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.

Antimicrob Agents Chemother. 1995 Nov;39(11):2378-86.

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