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Items: 1 to 20 of 181

1.

Regional brain uptake of the muscarinic ligand, [18F]FP-TZTP, is greatly decreased in M2 receptor knockout mice but not in M1, M3 and M4 receptor knockout mice.

Jagoda EM, Kiesewetter DO, Shimoji K, Ravasi L, Yamada M, Gomeza J, Wess J, Eckelman WC.

Neuropharmacology. 2003 Apr;44(5):653-61.

PMID:
12668051
2.

In vivo muscarinic binding of 3-(alkylthio)-3-thiadiazolyl tetrahydropyridines.

Kiesewetter DO, Carson RE, Jagoda EM, Herscovitch P, Eckelman WC.

Synapse. 1999 Jan;31(1):29-40.

PMID:
10025681
3.

Inhibition of [18F]FP-TZTP binding by loading doses of muscarinic agonists P-TZTP or FP-TZTP in vivo is not due to agonist-induced reduction in cerebral blood flow.

Shimoji K, Esaki T, Itoh Y, Ravasi L, Cook M, Jehle J, Jagoda EM, Kiesewetter DO, Schmidt K, Sokoloff L, Eckelman WC.

Synapse. 2003 Nov;50(2):151-63.

PMID:
12923818
4.
5.

Characterization of central inhibitory muscarinic autoreceptors by the use of muscarinic acetylcholine receptor knock-out mice.

Zhang W, Basile AS, Gomeza J, Volpicelli LA, Levey AI, Wess J.

J Neurosci. 2002 Mar 1;22(5):1709-17.

7.

Roles of M2 and M4 muscarinic receptors in regulating acetylcholine release from myenteric neurons of mouse ileum.

Takeuchi T, Fujinami K, Goto H, Fujita A, Taketo MM, Manabe T, Matsui M, Hata F.

J Neurophysiol. 2005 May;93(5):2841-8.

8.

An improved radiosynthesis of the muscarinic M2 radiopharmaceutical, [18F]FP-TZTP.

van Oosten EM, Wilson AA, Stephenson KA, Mamo DC, Pollock BG, Mulsant BH, Yudin AK, Houle S, Vasdev N.

Appl Radiat Isot. 2009 Apr;67(4):611-6. doi: 10.1016/j.apradiso.2008.12.015.

PMID:
19186063
9.
10.

Higher in vivo muscarinic-2 receptor distribution volumes in aging subjects with an apolipoprotein E-epsilon4 allele.

Cohen RM, Podruchny TA, Bokde AL, Carson RE, Herscovitch P, Kiesewetter DO, Eckelman WC, Sunderland T.

Synapse. 2003 Sep 1;49(3):150-6.

PMID:
12774299
11.

Comparison of the pharmacokinetics of different analogs of 11C-labeled TZTP for imaging muscarinic M2 receptors with PET.

Reid AE, Ding YS, Eckelman WC, Logan J, Alexoff D, Shea C, Xu Y, Fowler JS.

Nucl Med Biol. 2008 Apr;35(3):287-98. doi: 10.1016/j.nucmedbio.2008.01.001.

12.

M1 muscarinic receptor signaling in mouse hippocampus and cortex.

Porter AC, Bymaster FP, DeLapp NW, Yamada M, Wess J, Hamilton SE, Nathanson NM, Felder CC.

Brain Res. 2002 Jul 19;944(1-2):82-9.

PMID:
12106668
13.

Determination of [18F]FCWAY, [18F]FP-TZTP, and their metabolites in plasma using rapid and efficient liquid-liquid and solid phase extractions.

Ma Y, Kiesewetter DO, Lang L, Der M, Huang B, Carson RE, Eckelman WC.

Nucl Med Biol. 2003 Apr;30(3):233-40.

PMID:
12745014
14.

The automated radiosynthesis of [18F]FP-TZTP.

Kiesewetter DO, Vuong BK, Channing MA.

Nucl Med Biol. 2003 Jan;30(1):73-7.

PMID:
12493545
15.

In vivo muscarinic 2 receptor imaging in cognitively normal young and older volunteers.

Podruchny TA, Connolly C, Bokde A, Herscovitch P, Eckelman WC, Kiesewetter DO, Sunderland T, Carson RE, Cohen RM.

Synapse. 2003 Apr;48(1):39-44.

PMID:
12557271
17.

Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors.

Jakubík J, Bacáková L, El-Fakahany EE, Tucek S.

Mol Pharmacol. 1997 Jul;52(1):172-9.

18.

Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines .

Sauerberg P, Olesen PH, Nielsen S, Treppendahl S, Sheardown MJ, Honoré T, Mitch CH, Ward JS, Pike AJ, Bymaster FP, et al.

J Med Chem. 1992 Jun 12;35(12):2274-83.

PMID:
1613751
19.
20.

M1 receptor agonist activity is not a requirement for muscarinic antinociception.

Sheardown MJ, Shannon HE, Swedberg MD, Suzdak PD, Bymaster FP, Olesen PH, Mitch CH, Ward JS, Sauerberg P.

J Pharmacol Exp Ther. 1997 May;281(2):868-75.

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