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Items: 1 to 20 of 156

1.

An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro.

Sugimoto H, Shichijo M, Iino T, Manabe Y, Watanabe A, Shimazaki M, Gantner F, Bacon KB.

J Pharmacol Exp Ther. 2003 Apr;305(1):347-52.

PMID:
12649388
2.

A novel antagonist of prostaglandin D2 blocks the locomotion of eosinophils and basophils.

Royer JF, Schratl P, Carrillo JJ, Jupp R, Barker J, Weyman-Jones C, Beri R, Sargent C, Schmidt JA, Lang-Loidolt D, Heinemann A.

Eur J Clin Invest. 2008 Sep;38(9):663-71. doi: 10.1111/j.1365-2362.2008.01989.x.

PMID:
18837743
3.

Prostaglandin D2-induced eosinophilic airway inflammation is mediated by CRTH2 receptor.

Shiraishi Y, Asano K, Nakajima T, Oguma T, Suzuki Y, Shiomi T, Sayama K, Niimi K, Wakaki M, Kagyo J, Ikeda E, Hirai H, Yamaguchi K, Ishizaka A.

J Pharmacol Exp Ther. 2005 Mar;312(3):954-60. Epub 2004 Nov 4.

PMID:
15528449
4.

Inhibitory effect of the 4-aminotetrahydroquinoline derivatives, selective chemoattractant receptor-homologous molecule expressed on T helper 2 cell antagonists, on eosinophil migration induced by prostaglandin D2.

Mimura H, Ikemura T, Kotera O, Sawada M, Tashiro S, Fuse E, Ueno K, Manabe H, Ohshima E, Karasawa A, Miyaji H.

J Pharmacol Exp Ther. 2005 Jul;314(1):244-51. Epub 2005 Mar 29.

PMID:
15798001
5.

Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation.

Uller L, Mathiesen JM, Alenmyr L, Korsgren M, Ulven T, Högberg T, Andersson G, Persson CG, Kostenis E.

Respir Res. 2007 Feb 28;8:16.

6.
7.

Chemoattractant receptor-homologous molecule expressed on Th2 cells activation in vivo increases blood leukocyte counts and its blockade abrogates 13,14-dihydro-15-keto-prostaglandin D2-induced eosinophilia in rats.

Shichijo M, Sugimoto H, Nagao K, Inbe H, Encinas JA, Takeshita K, Bacon KB, Gantner F.

J Pharmacol Exp Ther. 2003 Nov;307(2):518-25. Epub 2003 Sep 15.

PMID:
12975488
8.

11-Dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils.

Böhm E, Sturm GJ, Weiglhofer I, Sandig H, Shichijo M, McNamee A, Pease JE, Kollroser M, Peskar BA, Heinemann A.

J Biol Chem. 2004 Feb 27;279(9):7663-70. Epub 2003 Dec 10.

9.

Differential modulation of human basophil functions through prostaglandin D2 receptors DP and chemoattractant receptor-homologous molecule expressed on Th2 cells/DP2.

Yoshimura-Uchiyama C, Iikura M, Yamaguchi M, Nagase H, Ishii A, Matsushima K, Yamamoto K, Shichijo M, Bacon KB, Hirai K.

Clin Exp Allergy. 2004 Aug;34(8):1283-90.

PMID:
15298571
10.

Pharmacologic profile of OC000459, a potent, selective, and orally active D prostanoid receptor 2 antagonist that inhibits mast cell-dependent activation of T helper 2 lymphocytes and eosinophils.

Pettipher R, Vinall SL, Xue L, Speight G, Townsend ER, Gazi L, Whelan CJ, Armer RE, Payton MA, Hunter MG.

J Pharmacol Exp Ther. 2012 Feb;340(2):473-82. doi: 10.1124/jpet.111.187203. Epub 2011 Nov 21.

PMID:
22106101
11.

CRTH2-specific binding characteristics of [3H]ramatroban and its effects on PGD2-, 15-deoxy-Delta12, 14-PGJ2- and indomethacin-induced agonist responses.

Sugimoto H, Shichijo M, Okano M, Bacon KB.

Eur J Pharmacol. 2005 Nov 7;524(1-3):30-7. Epub 2005 Oct 27.

PMID:
16256979
12.

CRTH2 mediates the activation of human Th2 cells in response to PGD(2) released from IgE/anti-IgE treated nasal polyp tissue.

Pérez-Novo CA, Holtappels G, Vinall SL, Xue L, Zhang N, Bachert C, Pettipher R.

Allergy. 2010 Mar;65(3):304-10. doi: 10.1111/j.1398-9995.2009.02204.x. Epub 2009 Oct 12.

PMID:
19839971
13.

Prostaglandin H2 induces the migration of human eosinophils through the chemoattractant receptor homologous molecule of Th2 cells, CRTH2.

Schuligoi R, Sedej M, Waldhoer M, Vukoja A, Sturm EM, Lippe IT, Peskar BA, Heinemann A.

J Leukoc Biol. 2009 Jan;85(1):136-45. doi: 10.1189/jlb.0608387. Epub 2008 Oct 3.

PMID:
18835884
14.

CRTH2 is a prominent effector in contact hypersensitivity-induced neutrophil inflammation.

Takeshita K, Yamasaki T, Nagao K, Sugimoto H, Shichijo M, Gantner F, Bacon KB.

Int Immunol. 2004 Jul;16(7):947-59. Epub 2004 Jun 1.

PMID:
15173122
15.

Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP.

Gervais FG, Cruz RP, Chateauneuf A, Gale S, Sawyer N, Nantel F, Metters KM, O'neill GP.

J Allergy Clin Immunol. 2001 Dec;108(6):982-8.

PMID:
11742277
16.

Novel function of CRTH2 in preventing apoptosis of human Th2 cells through activation of the phosphatidylinositol 3-kinase pathway.

Xue L, Barrow A, Pettipher R.

J Immunol. 2009 Jun 15;182(12):7580-6. doi: 10.4049/jimmunol.0804090.

17.

Ramatroban (BAY u 3405): a novel dual antagonist of TXA2 receptor and CRTh2, a newly identified prostaglandin D2 receptor.

Ishizuka T, Matsui T, Okamoto Y, Ohta A, Shichijo M.

Cardiovasc Drug Rev. 2004 Summer;22(2):71-90. Review.

PMID:
15179446
19.

Antagonists of the prostaglandin D2 receptor CRTH2.

Pettipher R, Hansel TT.

Drug News Perspect. 2008 Jul-Aug;21(6):317-22. doi: 10.1358/dnp.2008.21.6.1246831. Review.

PMID:
18836589

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