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Items: 1 to 20 of 138

1.

Synthesis of two fluoro analogues of the nicotinic acetylcholine receptor agonist UB-165.

Sutherland A, Gallagher T, Sharples CG, Wonnacott S.

J Org Chem. 2003 Mar 21;68(6):2475-8.

PMID:
12636420
2.

Synthesis and pharmacological characterization of novel analogues of the nicotinic acetylcholine receptor agonist (+/-)-UB-165.

Sharples CG, Karig G, Simpson GL, Spencer JA, Wright E, Millar NS, Wonnacott S, Gallagher T.

J Med Chem. 2002 Jul 18;45(15):3235-45.

PMID:
12109907
3.

Synthesis and nicotinic binding of novel phenyl derivatives of UB-165. Identifying factors associated with alpha7 selectivity.

Karig G, Large JM, Sharples CG, Sutherland A, Gallagher T, Wonnacott S.

Bioorg Med Chem Lett. 2003 Sep 1;13(17):2825-8.

PMID:
14611837
4.

Synthesis and nicotinic binding studies on enantiopure diazine analogues of the novel (2-chloro-5-pyridyl)-9-azabicyclo[4.2.1]non-2-ene UB-165.

Gohlke H, Gündisch D, Schwarz S, Seitz G, Tilotta MC, Wegge T.

J Med Chem. 2002 Feb 28;45(5):1064-72.

PMID:
11855986
5.

Synthesis and structure-activity data of some new epibatidine analogues.

Seerden JP, Tulp MT, Scheeren HW, Kruse CG.

Bioorg Med Chem. 1998 Nov;6(11):2103-10.

PMID:
9881100
6.

Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 3'-substituted deschloroepibatidine analogues. Novel nicotinic antagonists.

Carroll FI, Ma W, Yokota Y, Lee JR, Brieaddy LE, Navarro HA, Damaj MI, Martin BR.

J Med Chem. 2005 Feb 24;48(4):1221-8.

PMID:
15715488
7.

(-)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the alpha 7 nicotinic acetylcholine receptor.

Mullen G, Napier J, Balestra M, DeCory T, Hale G, Macor J, Mack R, Loch J 3rd, Wu E, Kover A, Verhoest P, Sampognaro A, Phillips E, Zhu Y, Murray R, Griffith R, Blosser J, Gurley D, Machulskis A, Zongrone J, Rosen A, Gordon J.

J Med Chem. 2000 Nov 2;43(22):4045-50.

PMID:
11063601
8.

Epibatidine structure-activity relationships.

Carroll FI.

Bioorg Med Chem Lett. 2004 Apr 19;14(8):1889-96. Review. Erratum in: Bioorg Med Chem Lett. 2004 Nov 15;14(22):5713.

PMID:
15050621
9.

Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the alpha7 nicotinic acetylcholine receptor: in vitro and in vivo activity.

Acker BA, Jacobsen EJ, Rogers BN, Wishka DG, Reitz SC, Piotrowski DW, Myers JK, Wolfe ML, Groppi VE, Thornburgh BA, Tinholt PM, Walters RR, Olson BA, Fitzgerald L, Staton BA, Raub TJ, Krause M, Li KS, Hoffmann WE, Hajos M, Hurst RS, Walker DP.

Bioorg Med Chem Lett. 2008 Jun 15;18(12):3611-5. doi: 10.1016/j.bmcl.2008.04.070. Epub 2008 May 1.

PMID:
18490160
11.
12.

Synthesis and nicotinic acetylcholine receptor in vitro and in vivo pharmacological properties of 2'-fluoro-3'-(substituted phenyl)deschloroepibatidine analogues of 2'-fluoro-3'-(4-nitrophenyl)deschloroepibatidine.

Ondachi P, Castro A, Luetje CW, Damaj MI, Mascarella SW, Navarro HA, Carroll FI.

J Med Chem. 2012 Jul 26;55(14):6512-22. doi: 10.1021/jm300575y. Epub 2012 Jul 11.

13.

Structure-activity studies of diazabicyclo[3.3.0]octane-substituted pyrazines and pyridines as potent α4β2 nicotinic acetylcholine receptor ligands.

Scanio MJ, Shi L, Bunnelle WH, Anderson DJ, Helfrich RJ, Malysz J, Thorin-Hagene KK, Van Handel CE, Marsh KC, Lee CH, Gopalakrishnan M.

J Med Chem. 2011 Nov 10;54(21):7678-92. doi: 10.1021/jm201045m. Epub 2011 Oct 11.

PMID:
21962147
14.
15.

UB-165: a novel nicotinic agonist with subtype selectivity implicates the alpha4beta2* subtype in the modulation of dopamine release from rat striatal synaptosomes.

Sharples CG, Kaiser S, Soliakov L, Marks MJ, Collins AC, Washburn M, Wright E, Spencer JA, Gallagher T, Whiteaker P, Wonnacott S.

J Neurosci. 2000 Apr 15;20(8):2783-91.

16.

Synthesis and nicotinic acetylcholine receptor binding properties of bridged and fused ring analogues of epibatidine.

Carroll FI, Robinson TP, Brieaddy LE, Atkinson RN, Mascarella SW, Damaj MI, Martin BR, Navarro HA.

J Med Chem. 2007 Dec 13;50(25):6383-91. Epub 2007 Nov 10.

PMID:
17994682
17.

N,N-disubstituted piperazines: synthesis and affinities at alpha4beta2(*) and alpha7(*) neuronal nicotinic acetylcholine receptors.

Chen J, Norrholm S, Dwoskin LP, Crooks PA, Bai D.

Bioorg Med Chem Lett. 2003 Jan 6;13(1):97-100.

18.

Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 3'-(substituted phenyl)epibatidine analogues. Nicotinic partial agonists.

Carroll FI, Ma W, Deng L, Navarro HA, Damaj MI, Martin BR.

J Nat Prod. 2010 Mar 26;73(3):306-12. doi: 10.1021/np9006124.

19.

Synthesis and structure-activity relationships of 5-substituted pyridine analogues of 3.

Lin NH, Li Y, He Y, Holladay MW, Kuntzweiler T, Anderson DJ, Campbell JE, Arneric SP.

Bioorg Med Chem Lett. 2001 Mar 12;11(5):631-3.

PMID:
11266158
20.

Structure-activity studies and analgesic efficacy of N-(3-pyridinyl)-bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptors.

Bunnelle WH, Daanen JF, Ryther KB, Schrimpf MR, Dart MJ, Gelain A, Meyer MD, Frost JM, Anderson DJ, Buckley M, Curzon P, Cao YJ, Puttfarcken P, Searle X, Ji J, Putman CB, Surowy C, Toma L, Barlocco D.

J Med Chem. 2007 Jul 26;50(15):3627-44. Epub 2007 Jun 22.

PMID:
17585748

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