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A single amino acid substitution in the envelope protein of chimeric yellow fever-dengue 1 vaccine virus reduces neurovirulence for suckling mice and viremia/viscerotropism for monkeys.

Guirakhoo F, Zhang Z, Myers G, Johnson BW, Pugachev K, Nichols R, Brown N, Levenbook I, Draper K, Cyrek S, Lang J, Fournier C, Barrere B, Delagrave S, Monath TP.

J Virol. 2004 Sep;78(18):9998-10008.


Construction and characterization of chimeric tick-borne encephalitis/dengue type 4 viruses.

Pletnev AG, Bray M, Huggins J, Lai CJ.

Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10532-6.


Crucial role of the N-glycans on the viral E-envelope glycoprotein in DC-SIGN-mediated dengue virus infection.

Alen MM, Dallmeier K, Balzarini J, Neyts J, Schols D.

Antiviral Res. 2012 Dec;96(3):280-7. doi: 10.1016/j.antiviral.2012.10.007. Epub 2012 Oct 31.


Chimeric dengue type 2 (vaccine strain PDK-53)/dengue type 1 virus as a potential candidate dengue type 1 virus vaccine.

Huang CY, Butrapet S, Pierro DJ, Chang GJ, Hunt AR, Bhamarapravati N, Gubler DJ, Kinney RM.

J Virol. 2000 Apr;74(7):3020-8.


Single point mutations in the helicase domain of the NS3 protein enhance dengue virus replicative capacity in human monocyte-derived dendritic cells and circumvent the type I interferon response.

Silveira GF, Strottmann DM, de Borba L, Mansur DS, Zanchin NI, Bordignon J, dos Santos CN.

Clin Exp Immunol. 2016 Jan;183(1):114-28. doi: 10.1111/cei.12701. Epub 2015 Oct 18.


Analysis of the replication kinetics of the ChimeriVax-DEN 1, 2, 3, 4 tetravalent virus mixture in Aedes aegypti by real-time reverse transcriptase-polymerase chain reaction.

Johnson BW, Chambers TV, Crabtree MB, Guirakhoo F, Monath TP, Miller BR.

Am J Trop Med Hyg. 2004 Jan;70(1):89-97.


Replication of chimeric yellow fever virus-dengue serotype 1-4 virus vaccine strains in dendritic and hepatic cells.

Brandler S, Brown N, Ermak TH, Mitchell F, Parsons M, Zhang Z, Lang J, Monath TP, Guirakhoo F.

Am J Trop Med Hyg. 2005 Jan;72(1):74-81.


Genetic basis of attenuation of dengue virus type 4 small plaque mutants with restricted replication in suckling mice and in SCID mice transplanted with human liver cells.

Blaney JE Jr, Johnson DH, Manipon GG, Firestone CY, Hanson CT, Murphy BR, Whitehead SS.

Virology. 2002 Aug 15;300(1):125-39.


Selection for virulent dengue viruses occurs in humans and mosquitoes.

Cologna R, Armstrong PM, Rico-Hesse R.

J Virol. 2005 Jan;79(2):853-9.


Essential role of dengue virus envelope protein N glycosylation at asparagine-67 during viral propagation.

Mondotte JA, Lozach PY, Amara A, Gamarnik AV.

J Virol. 2007 Jul;81(13):7136-48. Epub 2007 Apr 25.


Derivation and characterization of a dengue type 1 host range-restricted mutant virus that is attenuated and highly immunogenic in monkeys.

Markoff L, Pang X, Houng Hs HS, Falgout B, Olsen R, Jones E, Polo S.

J Virol. 2002 Apr;76(7):3318-28.


Construction of infectious cDNA clones for dengue 2 virus: strain 16681 and its attenuated vaccine derivative, strain PDK-53.

Kinney RM, Butrapet S, Chang GJ, Tsuchiya KR, Roehrig JT, Bhamarapravati N, Gubler DJ.

Virology. 1997 Apr 14;230(2):300-8.


Determinants in the envelope E protein and viral RNA helicase NS3 that influence the induction of apoptosis in response to infection with dengue type 1 virus.

Duarte dos Santos CN, Frenkiel MP, Courageot MP, Rocha CF, Vazeille-Falcoz MC, Wien MW, Rey FA, Deubel V, Despr├Ęs P.

Virology. 2000 Sep 1;274(2):292-308.


Growth-restricted dengue virus mutants containing deletions in the 5' noncoding region of the RNA genome.

Cahour A, Pletnev A, Vazielle-Falcoz M, Rosen L, Lai CJ.

Virology. 1995 Feb 20;207(1):68-76.


RNA interference mediated silencing of Hsp60 gene in human monocytic myeloma cell line U937 revealed decreased dengue virus multiplication.

Padwad YS, Mishra KP, Jain M, Chanda S, Karan D, Ganju L.

Immunobiology. 2009;214(6):422-9. doi: 10.1016/j.imbio.2008.11.010. Epub 2009 Mar 3.


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