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Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor.

Davidson D, Bakinowski M, Thomas ML, Horejsi V, Veillette A.

Mol Cell Biol. 2003 Mar;23(6):2017-28.


PAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytes.

Davidson D, Schraven B, Veillette A.

Mol Cell Biol. 2007 Mar;27(5):1960-73. Epub 2007 Jan 8.


Cutting edge: Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells.

Yasuda K, Nagafuku M, Shima T, Okada M, Yagi T, Yamada T, Minaki Y, Kato A, Tani-Ichi S, Hamaoka T, Kosugi A.

J Immunol. 2002 Sep 15;169(6):2813-7.


Protein tyrosine phosphatase alpha regulates Fyn activity and Cbp/PAG phosphorylation in thymocyte lipid rafts.

Maksumova L, Le HT, Muratkhodjaev F, Davidson D, Veillette A, Pallen CJ.

J Immunol. 2005 Dec 15;175(12):7947-56.


Targeting of CD45 protein tyrosine phosphatase activity to lipid microdomains on the T cell surface inhibits TCR signaling.

He X, Woodford-Thomas TA, Johnson KG, Shah DD, Thomas ML.

Eur J Immunol. 2002 Sep;32(9):2578-87.


Release from tonic inhibition of T cell activation through transient displacement of C-terminal Src kinase (Csk) from lipid rafts.

Torgersen KM, Vang T, Abrahamsen H, Yaqub S, Horejsí V, Schraven B, Rolstad B, Mustelin T, Taskén K.

J Biol Chem. 2001 Aug 3;276(31):29313-8. Epub 2001 Jun 4.


Combined spatial and enzymatic regulation of Csk by cAMP and protein kinase a inhibits T cell receptor signaling.

Vang T, Abrahamsen H, Myklebust S, Horejsí V, Taskén K.

J Biol Chem. 2003 May 16;278(20):17597-600. Epub 2003 Mar 28.


Regulation of FynT function by dual domain docking on PAG/Cbp.

Solheim SA, Torgersen KM, Taskén K, Berge T.

J Biol Chem. 2008 Feb 1;283(5):2773-83. Epub 2007 Dec 4.


A displaced PAG enhances proximal signaling and SDF-1-induced T cell migration.

Posevitz-Fejfár A, Smída M, Kliche S, Hartig R, Schraven B, Lindquist JA.

Eur J Immunol. 2008 Jan;38(1):250-9.


Stimulatory effects of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events.

Secrist JP, Burns LA, Karnitz L, Koretzky GA, Abraham RT.

J Biol Chem. 1993 Mar 15;268(8):5886-93.


Defective thymocyte maturation by transgenic expression of a truncated form of the T lymphocyte adapter molecule and Fyn substrate, Sin.

Donlin LT, Roman CA, Adlam M, Regelmann AG, Alexandropoulos K.

J Immunol. 2002 Dec 15;169(12):6900-9. Erratum in: J Immunol. 2003 Feb 15;170(4):2242..


Aberrant TCR-mediated signaling in CD45-null thymocytes involves dysfunctional regulation of Lck, Fyn, TCR-zeta, and ZAP-70.

Stone JD, Conroy LA, Byth KF, Hederer RA, Howlett S, Takemoto Y, Holmes N, Alexander DR.

J Immunol. 1997 Jun 15;158(12):5773-82.


Revisiting the Timing of Action of the PAG Adaptor Using Quantitative Proteomics Analysis of Primary T Cells.

Reginald K, Chaoui K, Roncagalli R, Beau M, Goncalves Menoita M, Monsarrat B, Burlet-Schiltz O, Malissen M, Gonzalez de Peredo A, Malissen B.

J Immunol. 2015 Dec 1;195(11):5472-81. doi: 10.4049/jimmunol.1501300. Epub 2015 Oct 28.


CD45 signals outside of lipid rafts to promote ERK activation, synaptic raft clustering, and IL-2 production.

Zhang M, Moran M, Round J, Low TA, Patel VP, Tomassian T, Hernandez JD, Miceli MC.

J Immunol. 2005 Feb 1;174(3):1479-90.


Removal of C-terminal SRC kinase from the immune synapse by a new binding protein.

Rahmouni S, Vang T, Alonso A, Williams S, van Stipdonk M, Soncini C, Moutschen M, Schoenberger SP, Mustelin T.

Mol Cell Biol. 2005 Mar;25(6):2227-41.

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