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Items: 1 to 20 of 114

2.

Investigations on the metal switch region of human porphobilinogen synthase.

Jaffe EK.

J Biol Inorg Chem. 2003 Jan;8(1-2):176-84. Epub 2002 Sep 28.

PMID:
12459913
3.
4.

Porphobilinogen synthase, the first source of heme's asymmetry.

Jaffe EK.

J Bioenerg Biomembr. 1995 Apr;27(2):169-79. Review.

PMID:
7592564
5.

Pseudomonas aeruginosa contains a novel type V porphobilinogen synthase with no required catalytic metal ions.

Frankenberg N, Jahn D, Jaffe EK.

Biochemistry. 1999 Oct 19;38(42):13976-82.

PMID:
10529244
6.

Tracking the evolution of porphobilinogen synthase metal dependence in vitro.

Frère F, Reents H, Schubert WD, Heinz DW, Jahn D.

J Mol Biol. 2005 Feb 4;345(5):1059-70. Epub 2004 Dec 21.

PMID:
15644204
7.

Porphobilinogen synthase from Escherichia coli is a Zn(II) metalloenzyme stimulated by Mg(II).

Mitchell LW, Jaffe EK.

Arch Biochem Biophys. 1993 Jan;300(1):169-77.

PMID:
8424649
8.

The porphobilinogen synthase family of metalloenzymes.

Jaffe EK.

Acta Crystallogr D Biol Crystallogr. 2000 Feb;56(Pt 2):115-28. Review.

PMID:
10666591
9.

Mechanistic basis for suicide inactivation of porphobilinogen synthase by 4,7-dioxosebacic acid, an inhibitor that shows dramatic species selectivity.

Kervinen J, Jaffe EK, Stauffer F, Neier R, Wlodawer A, Zdanov A.

Biochemistry. 2001 Jul 27;40(28):8227-36.

PMID:
11444968
10.

Rhodobacter capsulatus porphobilinogen synthase, a high activity metal ion independent hexamer.

Bollivar DW, Clauson C, Lighthall R, Forbes S, Kokona B, Fairman R, Kundrat L, Jaffe EK.

BMC Biochem. 2004 Nov 22;5:17.

11.

A structural basis for half-of-the-sites metal binding revealed in Drosophila melanogaster porphobilinogen synthase.

Kundrat L, Martins J, Stith L, Dunbrack RL Jr, Jaffe EK.

J Biol Chem. 2003 Aug 15;278(33):31325-30. Epub 2003 Jun 6.

12.
13.

5-Chlorolevulinate modification of porphobilinogen synthase identifies a potential role for the catalytic zinc.

Jaffe EK, Abrams WR, Kaempfen HX, Harris KA Jr.

Biochemistry. 1992 Feb 25;31(7):2113-23.

PMID:
1346974
14.
15.

Control of tetrapyrrole biosynthesis by alternate quaternary forms of porphobilinogen synthase.

Breinig S, Kervinen J, Stith L, Wasson AS, Fairman R, Wlodawer A, Zdanov A, Jaffe EK.

Nat Struct Biol. 2003 Sep;10(9):757-63. Epub 2003 Aug 3.

PMID:
12897770
16.

Bradyrhizobium japonicum porphobilinogen synthase uses two Mg(II) and monovalent cations.

Petrovich RM, Litwin S, Jaffe EK.

J Biol Chem. 1996 Apr 12;271(15):8692-9.

17.

An artificial gene for human porphobilinogen synthase allows comparison of an allelic variation implicated in susceptibility to lead poisoning.

Jaffe EK, Volin M, Bronson-Mullins CR, Dunbrack RL Jr, Kervinen J, Martins J, Quinlan JF Jr, Sazinsky MH, Steinhouse EM, Yeung AT.

J Biol Chem. 2000 Jan 28;275(4):2619-26.

18.

Characterization of the role of the stimulatory magnesium of Escherichia coli porphobilinogen synthase.

Jaffe EK, Ali S, Mitchell LW, Taylor KM, Volin M, Markham GD.

Biochemistry. 1995 Jan 10;34(1):244-51.

PMID:
7819203
19.

Mechanistic implications of mutations to the active site lysine of porphobilinogen synthase.

Mitchell LW, Volin M, Martins J, Jaffe EK.

J Biol Chem. 2001 Jan 12;276(2):1538-44.

20.

Species-specific inhibition of porphobilinogen synthase by 4-oxosebacic acid.

Jaffe EK, Kervinen J, Martins J, Stauffer F, Neier R, Wlodawer A, Zdanov A.

J Biol Chem. 2002 May 31;277(22):19792-9. Epub 2002 Mar 21.

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