Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 457

1.

APP, Notch, and presenilin: molecular pieces in the puzzle of Alzheimer's disease.

Wolfe MS.

Int Immunopharmacol. 2002 Dec;2(13-14):1919-29. Review.

PMID:
12489805
2.

Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.

Steiner H, Capell A, Leimer U, Haass C.

Eur Arch Psychiatry Clin Neurosci. 1999;249(6):266-70. Review.

PMID:
10653281
3.

gamma-Secretase inhibitors as molecular probes of presenilin function.

Wolfe MS.

J Mol Neurosci. 2001 Oct;17(2):199-204. Review.

PMID:
11816793
4.

Secretase as a target for Alzheimer's disease.

Wolfe MS.

Curr Top Med Chem. 2002 Apr;2(4):371-83. Review.

PMID:
11966461
5.

BACE1: the beta-secretase enzyme in Alzheimer's disease.

Vassar R.

J Mol Neurosci. 2004;23(1-2):105-14. Review.

PMID:
15126696
6.

Role of presenilin in gamma-secretase cleavage of amyloid precursor protein.

Xia W.

Exp Gerontol. 2000 Jul;35(4):453-60. Review.

PMID:
10959033
7.

Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.

Wiley JC, Hudson M, Kanning KC, Schecterson LC, Bothwell M.

J Neurochem. 2005 Sep;94(5):1189-201. Epub 2005 Jun 30.

8.

The presenilins in Alzheimer's disease--proteolysis holds the key.

Haass C, De Strooper B.

Science. 1999 Oct 29;286(5441):916-9. Review.

PMID:
10542139
9.
10.
11.

Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.

Evin G, Zhu A, Holsinger RM, Masters CL, Li QX.

J Neurosci Res. 2003 Nov 1;74(3):386-92.

PMID:
14598315
12.

The beta-secretase, BACE: a prime drug target for Alzheimer's disease.

Vassar R.

J Mol Neurosci. 2001 Oct;17(2):157-70. Review.

PMID:
11816789
13.

Presenilin, Notch, and the genesis and treatment of Alzheimer's disease.

Selkoe DJ.

Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11039-41. Review.

14.

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.

Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ.

Nature. 1999 Apr 8;398(6727):513-7.

PMID:
10206644
15.

[Beta-amyloid protein: recent progress in basic research and therapeutic approaches].

Iwatsubo T.

Rinsho Shinkeigaku. 2001 Dec;41(12):1198-200. Review. Japanese.

PMID:
12235837
16.

The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease.

Tomita T, Iwatsubo T.

Drug News Perspect. 2004 Jun;17(5):321-5. Review.

PMID:
15334182
18.

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

Esler WP, Kimberly WT, Ostaszewski BL, Diehl TS, Moore CL, Tsai JY, Rahmati T, Xia W, Selkoe DJ, Wolfe MS.

Nat Cell Biol. 2000 Jul;2(7):428-34.

PMID:
10878808
19.

APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer's disease mutations.

Bergman A, Religa D, Karlström H, Laudon H, Winblad B, Lannfelt L, Lundkvist J, Näslund J.

Exp Cell Res. 2003 Jul 1;287(1):1-9.

PMID:
12799176
20.

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.

Bentahir M, Nyabi O, Verhamme J, Tolia A, Horré K, Wiltfang J, Esselmann H, De Strooper B.

J Neurochem. 2006 Feb;96(3):732-42. Epub 2006 Jan 9.

Supplemental Content

Support Center