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Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling.

Brdicka T, Imrich M, Angelisová P, Brdicková N, Horváth O, Spicka J, Hilgert I, Lusková P, Dráber P, Novák P, Engels N, Wienands J, Simeoni L, Osterreicher J, Aguado E, Malissen M, Schraven B, Horejsí V.

J Exp Med. 2002 Dec 16;196(12):1617-26.


T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane.

Bruyns E, Marie-Cardine A, Kirchgessner H, Sagolla K, Shevchenko A, Mann M, Autschbach F, Bensussan A, Meuer S, Schraven B.

J Exp Med. 1998 Aug 3;188(3):561-75.


Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function.

Wang Y, Horvath O, Hamm-Baarke A, Richelme M, Grégoire C, Guinamard R, Horejsi V, Angelisova P, Spicka J, Schraven B, Malissen B, Malissen M.

Mol Cell Biol. 2005 Jun;25(11):4455-65.


Identification of the minimal tyrosine residues required for linker for activation of T cell function.

Lin J, Weiss A.

J Biol Chem. 2001 Aug 3;276(31):29588-95. Epub 2001 Jun 6.


Functional complementation of BLNK by SLP-76 and LAT linker proteins.

Wong J, Ishiai M, Kurosaki T, Chan AC.

J Biol Chem. 2000 Oct 20;275(42):33116-22.


Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL.

Volná P, Lebduska P, Dráberová L, Símová S, Heneberg P, Boubelík M, Bugajev V, Malissen B, Wilson BS, Horejsí V, Malissen M, Dráber P.

J Exp Med. 2004 Oct 18;200(8):1001-13. Epub 2004 Oct 11.


Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development.

Sommers CL, Menon RK, Grinberg A, Zhang W, Samelson LE, Love PE.

J Exp Med. 2001 Jul 16;194(2):135-42.


The four distal tyrosines are required for LAT-dependent signaling in FcepsilonRI-mediated mast cell activation.

Saitoh S, Odom S, Gomez G, Sommers CL, Young HA, Rivera J, Samelson LE.

J Exp Med. 2003 Sep 1;198(5):831-43.


Gads/Grb2-mediated association with LAT is critical for the inhibitory function of Gab2 in T cells.

Yamasaki S, Nishida K, Sakuma M, Berry D, McGlade CJ, Hirano T, Saito T.

Mol Cell Biol. 2003 Apr;23(7):2515-29.


LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival.

Yamasaki S, Ishikawa E, Sakuma M, Kanagawa O, Cheng AM, Malissen B, Saito T.

Mol Cell Biol. 2007 Jun;27(12):4406-15. Epub 2007 Apr 9.


Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line.

Zhang W, Irvin BJ, Trible RP, Abraham RT, Samelson LE.

Int Immunol. 1999 Jun;11(6):943-50.


Regulation of Ca2+ signaling in mast cells by tyrosine-phosphorylated and unphosphorylated non-T cell activation linker.

Dráberová L, Shaik GM, Volná P, Heneberg P, Tůmová M, Lebduska P, Korb J, Dráber P.

J Immunol. 2007 Oct 15;179(8):5169-80.


The transmembrane adapter LAT plays a central role in immune receptor signalling.

Wonerow P, Watson SP.

Oncogene. 2001 Oct 1;20(44):6273-83. Review.

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