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Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury.

Belperio JA, Keane MP, Burdick MD, Londhe V, Xue YY, Li K, Phillips RJ, Strieter RM.

J Clin Invest. 2002 Dec;110(11):1703-16.


CXCR2 is critical to hyperoxia-induced lung injury.

Sue RD, Belperio JA, Burdick MD, Murray LA, Xue YY, Dy MC, Kwon JJ, Keane MP, Strieter RM.

J Immunol. 2004 Mar 15;172(6):3860-8.


CXCR2/CXCR2 ligand biology during lung transplant ischemia-reperfusion injury.

Belperio JA, Keane MP, Burdick MD, Gomperts BN, Xue YY, Hong K, Mestas J, Zisman D, Ardehali A, Saggar R, Lynch JP 3rd, Ross DJ, Strieter RM.

J Immunol. 2005 Nov 15;175(10):6931-9.


CXCR2/CXCR2 ligand biological axis impairs alveologenesis during dsRNA-induced lung inflammation in mice.

Londhe VA, Belperio JA, Keane MP, Burdick MD, Xue YY, Strieter RM.

Pediatr Res. 2005 Nov;58(5):919-26. Epub 2005 Sep 23.


CXC chemokine receptor-2 ligands are necessary components of neutrophil-mediated host defense in invasive pulmonary aspergillosis.

Mehrad B, Strieter RM, Moore TA, Tsai WC, Lira SA, Standiford TJ.

J Immunol. 1999 Dec 1;163(11):6086-94.


The role of CXCR2/CXCR2 ligands in acute lung injury.

Strieter RM, Keane MP, Burdick MD, Sakkour A, Murray LA, Belperio JA.

Curr Drug Targets Inflamm Allergy. 2005 Jun;4(3):299-303. Review.


Bacterial clearance and survival are dependent on CXC chemokine receptor-2 ligands in a murine model of pulmonary Nocardia asteroides infection.

Moore TA, Newstead MW, Strieter RM, Mehrad B, Beaman BL, Standiford TJ.

J Immunol. 2000 Jan 15;164(2):908-15.


Chemokine-dependent neutrophil recruitment in a murine model of Legionella pneumonia: potential role of neutrophils as immunoregulatory cells.

Tateda K, Moore TA, Newstead MW, Tsai WC, Zeng X, Deng JC, Chen G, Reddy R, Yamaguchi K, Standiford TJ.

Infect Immun. 2001 Apr;69(4):2017-24.


Developmental expression of two CXC chemokines, MIP-2 and KC, and their receptors.

Luan J, Furuta Y, Du J, Richmond A.

Cytokine. 2001 Jun 7;14(5):253-63.


CXCR2 inhibition suppresses hemorrhage-induced priming for acute lung injury in mice.

Lomas-Neira JL, Chung CS, Grutkoski PS, Miller EJ, Ayala A.

J Leukoc Biol. 2004 Jul;76(1):58-64. Epub 2004 May 3.


CXCR2 is critical for dsRNA-induced lung injury: relevance to viral lung infection.

Londhe VA, Belperio JA, Keane MP, Burdick MD, Xue YY, Strieter RM.

J Inflamm (Lond). 2005 May 28;2(1):4.


Depletion of CXCR2 inhibits tumor growth and angiogenesis in a murine model of lung cancer.

Keane MP, Belperio JA, Xue YY, Burdick MD, Strieter RM.

J Immunol. 2004 Mar 1;172(5):2853-60.


High expression of ligands for chemokine receptor CXCR2 in alveolar epithelial neoplasia induced by oncogenic kras.

Wislez M, Fujimoto N, Izzo JG, Hanna AE, Cody DD, Langley RR, Tang H, Burdick MD, Sato M, Minna JD, Mao L, Wistuba I, Strieter RM, Kurie JM.

Cancer Res. 2006 Apr 15;66(8):4198-207.


Critical role of endothelial CXCR2 in LPS-induced neutrophil migration into the lung.

Reutershan J, Morris MA, Burcin TL, Smith DF, Chang D, Saprito MS, Ley K.

J Clin Invest. 2006 Mar;116(3):695-702. Epub 2006 Feb 16.


CXCR2 antagonists block the N-Ac-PGP-induced neutrophil influx in the airways of mice, but not the production of the chemokine CXCL1.

Braber S, Overbeek SA, Koelink PJ, Henricks PA, Zaman GJ, Garssen J, Kraneveld AD, Folkerts G.

Eur J Pharmacol. 2011 Oct 15;668(3):443-9. doi: 10.1016/j.ejphar.2011.03.025. Epub 2011 Mar 31.


Generation and functional significance of CXC chemokines for neutrophil-induced liver injury during endotoxemia.

Dorman RB, Gujral JS, Bajt ML, Farhood A, Jaeschke H.

Am J Physiol Gastrointest Liver Physiol. 2005 May;288(5):G880-6. Epub 2004 Dec 2.

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