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Items: 1 to 20 of 187

1.

Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP.

Yang J, Cron P, Good VM, Thompson V, Hemmings BA, Barford D.

Nat Struct Biol. 2002 Dec;9(12):940-4.

PMID:
12434148
2.

Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation.

Yang J, Cron P, Thompson V, Good VM, Hess D, Hemmings BA, Barford D.

Mol Cell. 2002 Jun;9(6):1227-40.

3.

Regulation of protein kinases in insulin, growth factor and Wnt signalling.

Pearl LH, Barford D.

Curr Opin Struct Biol. 2002 Dec;12(6):761-7. Review.

PMID:
12504681
4.

A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation.

Frödin M, Antal TL, Dümmler BA, Jensen CJ, Deak M, Gammeltoft S, Biondi RM.

EMBO J. 2002 Oct 15;21(20):5396-407.

5.

The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation.

Bax B, Carter PS, Lewis C, Guy AR, Bridges A, Tanner R, Pettman G, Mannix C, Culbert AA, Brown MJ, Smith DG, Reith AD.

Structure. 2001 Dec;9(12):1143-52.

6.

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells.

Williams MR, Arthur JS, Balendran A, van der Kaay J, Poli V, Cohen P, Alessi DR.

Curr Biol. 2000 Apr 20;10(8):439-48.

7.

Structural insight into nucleotide recognition in tau-protein kinase I/glycogen synthase kinase 3 beta.

Aoki M, Yokota T, Sugiura I, Sasaki C, Hasegawa T, Okumura C, Ishiguro K, Kohno T, Sugio S, Matsuzaki T.

Acta Crystallogr D Biol Crystallogr. 2004 Mar;60(Pt 3):439-46. Epub 2004 Feb 25.

PMID:
14993667
8.

Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.

Obata T, Yaffe MB, Leparc GG, Piro ET, Maegawa H, Kashiwagi A, Kikkawa R, Cantley LC.

J Biol Chem. 2000 Nov 17;275(46):36108-15.

9.
10.

Serine 396 of PDK1 is required for maximal PKB activation.

Moon Z, Wang Y, Aryan N, Mousseau DD, Scheid MP.

Cell Signal. 2008 Nov;20(11):2038-49. doi: 10.1016/j.cellsig.2008.07.015. Epub 2008 Jul 30.

PMID:
18718528
11.

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.

Alessi DR, Deak M, Casamayor A, Caudwell FB, Morrice N, Norman DG, Gaffney P, Reese CB, MacDougall CN, Harbison D, Ashworth A, Bownes M.

Curr Biol. 1997 Oct 1;7(10):776-89.

12.
13.

Crystal structure of the kinase domain of serum and glucocorticoid-regulated kinase 1 in complex with AMP PNP.

Zhao B, Lehr R, Smallwood AM, Ho TF, Maley K, Randall T, Head MS, Koretke KK, Schnackenberg CG.

Protein Sci. 2007 Dec;16(12):2761-9. Epub 2007 Oct 26.

14.

Structural basis of constitutive activity and a unique nucleotide binding mode of human Pim-1 kinase.

Qian KC, Wang L, Hickey ER, Studts J, Barringer K, Peng C, Kronkaitis A, Li J, White A, Mische S, Farmer B.

J Biol Chem. 2005 Feb 18;280(7):6130-7. Epub 2004 Nov 3.

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18.

Identification of 14-3-3zeta as a protein kinase B/Akt substrate.

Powell DW, Rane MJ, Chen Q, Singh S, McLeish KR.

J Biol Chem. 2002 Jun 14;277(24):21639-42. Epub 2002 Apr 15.

19.

Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B.

Scheid MP, Marignani PA, Woodgett JR.

Mol Cell Biol. 2002 Sep;22(17):6247-60.

20.

Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding.

Komander D, Kular G, Deak M, Alessi DR, van Aalten DM.

J Biol Chem. 2005 May 13;280(19):18797-802. Epub 2005 Mar 1.

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