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CD8 T cell-mediated killing of Cryptococcus neoformans requires granulysin and is dependent on CD4 T cells and IL-15.

Ma LL, Spurrell JC, Wang JF, Neely GG, Epelman S, Krensky AM, Mody CH.

J Immunol. 2002 Nov 15;169(10):5787-95.


Cytotoxic CD4+ T cells use granulysin to kill Cryptococcus neoformans, and activation of this pathway is defective in HIV patients.

Zheng CF, Ma LL, Jones GJ, Gill MJ, Krensky AM, Kubes P, Mody CH.

Blood. 2007 Mar 1;109(5):2049-57. Epub 2006 Oct 12.


NK cells use perforin rather than granulysin for anticryptococcal activity.

Ma LL, Wang CL, Neely GG, Epelman S, Krensky AM, Mody CH.

J Immunol. 2004 Sep 1;173(5):3357-65.


CD4(+) and CD8(+) T cells kill intracellular Mycobacterium tuberculosis by a perforin and Fas/Fas ligand-independent mechanism.

Canaday DH, Wilkinson RJ, Li Q, Harding CV, Silver RF, Boom WH.

J Immunol. 2001 Sep 1;167(5):2734-42.


Generation of antifungal effector CD8+ T cells in the absence of CD4+ T cells during Cryptococcus neoformans infection.

Lindell DM, Moore TA, McDonald RA, Toews GB, Huffnagle GB.

J Immunol. 2005 Jun 15;174(12):7920-8.


Coordinate expression of CC chemokine ligand 5, granulysin, and perforin in CD8+ T cells provides a host defense mechanism against Mycobacterium tuberculosis.

Stegelmann F, Bastian M, Swoboda K, Bhat R, Kiessler V, Krensky AM, Roellinghoff M, Modlin RL, Stenger S.

J Immunol. 2005 Dec 1;175(11):7474-83.


Induction of granulysin in CD8+ T cells by IL-21 and IL-15 is suppressed by human immunodeficiency virus-1.

Hogg AE, Bowick GC, Herzog NK, Cloyd MW, Endsley JJ.

J Leukoc Biol. 2009 Nov;86(5):1191-203. doi: 10.1189/jlb.0409222. Epub 2009 Aug 17.


Disparate cytotoxic activity of nickel-specific CD8+ and CD4+ T cell subsets against keratinocytes.

Traidl C, Sebastiani S, Albanesi C, Merk HF, Puddu P, Girolomoni G, Cavani A.

J Immunol. 2000 Sep 15;165(6):3058-64.


Class I- and class II-reactive TCRs coexpressed on CD4+ T cells both trigger CD4/CD8-shared and CD4-unique functions.

Asnagli H, Schmitt-Verhulst AM, Guimezanes A.

J Immunol. 1997 May 15;158(10):4533-42.


Anti-TNF immunotherapy reduces CD8+ T cell-mediated antimicrobial activity against Mycobacterium tuberculosis in humans.

Bruns H, Meinken C, Schauenberg P, Härter G, Kern P, Modlin RL, Antoni C, Stenger S.

J Clin Invest. 2009 May;119(5):1167-77. doi: 10.1172/JCI38482. Epub 2009 Apr 20.


Essential roles of perforin in antigen-specific cytotoxicity mediated by human CD4+ T lymphocytes: analysis using the combination of hereditary perforin-deficient effector cells and Fas-deficient target cells.

Yanai F, Ishii E, Kojima K, Hasegawa A, Azuma T, Hirose S, Suga N, Mitsudome A, Zaitsu M, Ishida Y, Shirakata Y, Sayama K, Hashimoto K, Yasukawa M.

J Immunol. 2003 Feb 15;170(4):2205-13.


Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity.

Kataoka T, Shinohara N, Takayama H, Takaku K, Kondo S, Yonehara S, Nagai K.

J Immunol. 1996 May 15;156(10):3678-86.


Perforin-dependent cryptococcal microbicidal activity in NK cells requires PI3K-dependent ERK1/2 signaling.

Wiseman JC, Ma LL, Marr KJ, Jones GJ, Mody CH.

J Immunol. 2007 May 15;178(10):6456-64.

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