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Proliferative action of mast-cell tryptase is mediated by PAR2, COX2, prostaglandins, and PPARgamma : Possible relevance to human fibrotic disorders.

Frungieri MB, Weidinger S, Meineke V, Köhn FM, Mayerhofer A.

Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15072-7. Epub 2002 Oct 23.


Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2.

Akers IA, Parsons M, Hill MR, Hollenberg MD, Sanjar S, Laurent GJ, McAnulty RJ.

Am J Physiol Lung Cell Mol Physiol. 2000 Jan;278(1):L193-201.


Mast cells in human testicular biopsies from patients with mixed atrophy: increased numbers, heterogeneity, and expression of cyclooxygenase 2 and prostaglandin D2 synthase.

Welter H, Köhn FM, Mayerhofer A.

Fertil Steril. 2011 Aug;96(2):309-13. doi: 10.1016/j.fertnstert.2011.05.035. Epub 2011 Jun 17.


Tryptase increases proliferative activity of human conjunctival fibroblasts through protease-activated receptor-2.

Asano-Kato N, Fukagawa K, Okada N, Dogru M, Tsubota K, Fujishima H.

Invest Ophthalmol Vis Sci. 2005 Dec;46(12):4622-6.


Mast cell tryptase and proteinase-activated receptor 2 induce hyperexcitability of guinea-pig submucosal neurons.

Reed DE, Barajas-Lopez C, Cottrell G, Velazquez-Rocha S, Dery O, Grady EF, Bunnett NW, Vanner SJ.

J Physiol. 2003 Mar 1;547(Pt 2):531-42. Epub 2003 Jan 24.


Mast cell tryptase stimulates myoblast proliferation; a mechanism relying on protease-activated receptor-2 and cyclooxygenase-2.

Duchesne E, Tremblay MH, Côté CH.

BMC Musculoskelet Disord. 2011 Oct 14;12:235. doi: 10.1186/1471-2474-12-235.


Mast cell tryptase controls paracellular permeability of the intestine. Role of protease-activated receptor 2 and beta-arrestins.

Jacob C, Yang PC, Darmoul D, Amadesi S, Saito T, Cottrell GS, Coelho AM, Singh P, Grady EF, Perdue M, Bunnett NW.

J Biol Chem. 2005 Sep 9;280(36):31936-48. Epub 2005 Jul 18.


Reaction of mast cell proteases tryptase and chymase with protease activated receptors (PARs) on keratinocytes and fibroblasts.

Schechter NM, Brass LF, Lavker RM, Jensen PJ.

J Cell Physiol. 1998 Aug;176(2):365-73.


Are testicular mast cells involved in the regulation of germ cells in man?

Windschüttl S, Nettersheim D, Schlatt S, Huber A, Welter H, Schwarzer JU, Köhn FM, Schorle H, Mayerhofer A.

Andrology. 2014 Jul;2(4):615-22. doi: 10.1111/j.2047-2927.2014.00227.x. Epub 2014 Jun 12.


Inflammatory mediators modulate thrombin and cathepsin-G signaling in human bronchial fibroblasts by inducing expression of proteinase-activated receptor-4.

Ramachandran R, Sadofsky LR, Xiao Y, Botham A, Cowen M, Morice AH, Compton SJ.

Am J Physiol Lung Cell Mol Physiol. 2007 Mar;292(3):L788-98. Epub 2006 Dec 1.


Proteinase-activated receptor-2 in human skin: tissue distribution and activation of keratinocytes by mast cell tryptase.

Steinhoff M, Corvera CU, Thoma MS, Kong W, McAlpine BE, Caughey GH, Ansel JC, Bunnett NW.

Exp Dermatol. 1999 Aug;8(4):282-94.


Expression and function of proteinase-activated receptor 2 in human bronchial smooth muscle.

Schmidlin F, Amadesi S, Vidil R, Trevisani M, Martinet N, Caughey G, Tognetto M, Cavallesco G, Mapp C, Geppetti P, Bunnett NW.

Am J Respir Crit Care Med. 2001 Oct 1;164(7):1276-81.


Role of mast cell tryptase in renal interstitial fibrosis.

Kondo S, Kagami S, Kido H, Strutz F, Müller GA, Kuroda Y.

J Am Soc Nephrol. 2001 Aug;12(8):1668-76.


Human mast cells stimulate fibroblast proliferation, collagen synthesis and lattice contraction: a direct role for mast cells in skin fibrosis.

Garbuzenko E, Nagler A, Pickholtz D, Gillery P, Reich R, Maquart FX, Levi-Schaffer F.

Clin Exp Allergy. 2002 Feb;32(2):237-46.


15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway.

Straus DS, Pascual G, Li M, Welch JS, Ricote M, Hsiang CH, Sengchanthalangsy LL, Ghosh G, Glass CK.

Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4844-9.

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