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Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease.

Donaldson GC, Seemungal TA, Bhowmik A, Wedzicha JA.

Thorax. 2002 Oct;57(10):847-52. Erratum in: Thorax. 2008 Aug;63(8):753.


Exacerbations and lung function decline in COPD: new insights in current and ex-smokers.

Makris D, Moschandreas J, Damianaki A, Ntaoukakis E, Siafakas NM, Milic Emili J, Tzanakis N.

Respir Med. 2007 Jun;101(6):1305-12. Epub 2006 Nov 16.


Tiotropium bromide. A review of its use as maintenance therapy in patients with COPD.

Keam SJ, Keating GM.

Treat Respir Med. 2004;3(4):247-68. Review.


Inspiratory capacity and forced expiratory volume in the first second in exacerbation of chronic obstructive pulmonary disease.

Yetkin O, Gunen H.

Clin Respir J. 2008 Jan;2(1):36-40. doi: 10.1111/j.1752-699X.2007.00040.x.


Effect of exacerbations on quality of life in patients with chronic obstructive pulmonary disease: a 2 year follow up study.

Miravitlles M, Ferrer M, Pont A, Zalacain R, Alvarez-Sala JL, Masa F, Verea H, Murio C, Ros F, Vidal R; IMPAC Study Group.

Thorax. 2004 May;59(5):387-95.


Exacerbations of chronic obstructive pulmonary disease.

Wedzicha JA, Donaldson GC.

Respir Care. 2003 Dec;48(12):1204-13; discussion 1213-5. Review.


Predictors of lung function and its decline in mild to moderate COPD in association with gender: results from the Euroscop study.

Watson L, Vonk JM, Löfdahl CG, Pride NB, Pauwels RA, Laitinen LA, Schouten JP, Postma DS; European Respiratory Society Study on Chronic Obstructive Pulmonary Disease.

Respir Med. 2006 Apr;100(4):746-53. Epub 2005 Sep 30.


Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations.

Patel IS, Seemungal TA, Wilks M, Lloyd-Owen SJ, Donaldson GC, Wedzicha JA.

Thorax. 2002 Sep;57(9):759-64.


[Effect of lung transplantation on pulmonary function in 5 patients with chronic obstructive pulmonary disease].

Liu JM, Yang WL, Jiang GN, Ding JA, Wang YM, Zheng W, Zhu D, Gao BL, Jiang P, Wu W.

Zhonghua Jie He He Hu Xi Za Zhi. 2005 Aug;28(8):509-12. Chinese.


Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease.

Soler-Cataluña JJ, Martínez-García MA, Román Sánchez P, Salcedo E, Navarro M, Ochando R.

Thorax. 2005 Nov;60(11):925-31. Epub 2005 Jul 29.


Lung function and indicators of exposure to indoor and outdoor particulate matter among asthma and COPD patients.

de Hartog JJ, Ayres JG, Karakatsani A, Analitis A, Brink HT, Hameri K, Harrison R, Katsouyanni K, Kotronarou A, Kavouras I, Meddings C, Pekkanen J, Hoek G.

Occup Environ Med. 2010 Jan;67(1):2-10. doi: 10.1136/oem.2008.040857. Epub 2009 Sep 6.


Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations.

Bhowmik A, Seemungal TA, Sapsford RJ, Wedzicha JA.

Thorax. 2000 Feb;55(2):114-20.


Effect of preceding inspiratory speed and end-inspiratory pause on forced expiratory manoeuvre in healthy subjects and chronic obstructive pulmonary disease patients.

Boni E, Chiari S, Trigiani M, Gatta D, Pini L, Tantucci C.

Respiration. 2009;78(3):270-7. doi: 10.1159/000209741. Epub 2009 Mar 20.


Fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease: 5-year follow-up.

Contoli M, Baraldo S, Marku B, Casolari P, Marwick JA, Turato G, Romagnoli M, Caramori G, Saetta M, Fabbri LM, Papi A.

J Allergy Clin Immunol. 2010 Apr;125(4):830-7. doi: 10.1016/j.jaci.2010.01.003. Epub 2010 Mar 15.


Prednisolone response in patients with chronic obstructive pulmonary disease: results from the ISOLDE study.

Burge PS, Calverley PM, Jones PW, Spencer S, Anderson JA.

Thorax. 2003 Aug;58(8):654-8.


Exacerbations worsen the quality of life of chronic obstructive pulmonary disease patients in primary healthcare.

Llor C, Molina J, Naberan K, Cots JM, Ros F, Miravitlles M; EVOCA study group.

Int J Clin Pract. 2008 Apr;62(4):585-92. doi: 10.1111/j.1742-1241.2008.01707.x. Epub 2008 Feb 7.


A prospective study of decline in fat free mass and skeletal muscle strength in chronic obstructive pulmonary disease.

Hopkinson NS, Tennant RC, Dayer MJ, Swallow EB, Hansel TT, Moxham J, Polkey MI.

Respir Res. 2007 Mar 13;8:25.


Acute exacerbations of chronic obstructive pulmonary disease are accompanied by elevations of plasma fibrinogen and serum IL-6 levels.

Wedzicha JA, Seemungal TA, MacCallum PK, Paul EA, Donaldson GC, Bhowmik A, Jeffries DJ, Meade TW.

Thromb Haemost. 2000 Aug;84(2):210-5.


Do frequent moderate exacerbations contribute to progression of chronic obstructive pulmonary disease in patients who are ex-smokers?

Dreyse J, Díaz O, Repetto PB, Morales A, Saldías F, Lisboa C.

Int J Chron Obstruct Pulmon Dis. 2015 Mar 10;10:525-33. doi: 10.2147/COPD.S76475. eCollection 2015.

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