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IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells.

Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J, Hibbert L, Churakova T, Travis M, Vaisberg E, Blumenschein WM, Mattson JD, Wagner JL, To W, Zurawski S, McClanahan TK, Gorman DM, Bazan JF, de Waal Malefyt R, Rennick D, Kastelein RA.

Immunity. 2002 Jun;16(6):779-90.


Expression of IL-27 in human Th1-associated granulomatous diseases.

Larousserie F, Pflanz S, Coulomb-L'Herminé A, Brousse N, Kastelein R, Devergne O.

J Pathol. 2004 Feb;202(2):164-71.


The power of combinatorial immunology: IL-12 and IL-12-related dimeric cytokines in infectious diseases.

Hölscher C.

Med Microbiol Immunol. 2004 Feb;193(1):1-17. Review.


Further checkpoints in Th1 development.

Robinson DS, O'Garra A.

Immunity. 2002 Jun;16(6):755-8. Review.


The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling.

Crabé S, Guay-Giroux A, Tormo AJ, Duluc D, Lissilaa R, Guilhot F, Mavoungou-Bigouagou U, Lefouili F, Cognet I, Ferlin W, Elson G, Jeannin P, Gauchat JF.

J Immunol. 2009 Dec 15;183(12):7692-702. doi: 10.4049/jimmunol.0901464.


IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms.

Lucas S, Ghilardi N, Li J, de Sauvage FJ.

Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15047-52.


Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment.

Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, Mak TW, Yoshimura A, Yoshida H.

J Immunol. 2003 May 15;170(10):4886-90.


Induction of cytokine production in naive CD4(+) T cells by antigen-presenting murine liver sinusoidal endothelial cells but failure to induce differentiation toward Th1 cells.

Knolle PA, Schmitt E, Jin S, Germann T, Duchmann R, Hegenbarth S, Gerken G, Lohse AW.

Gastroenterology. 1999 Jun;116(6):1428-40.


B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation.

Murphy EE, Terres G, Macatonia SE, Hsieh CS, Mattson J, Lanier L, Wysocka M, Trinchieri G, Murphy K, O'Garra A.

J Exp Med. 1994 Jul 1;180(1):223-31.


Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice.

Nieuwenhuis EE, Neurath MF, Corazza N, Iijima H, Trgovcich J, Wirtz S, Glickman J, Bailey D, Yoshida M, Galle PR, Kronenberg M, Birkenbach M, Blumberg RS.

Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16951-6.


An indispensable role for STAT1 in IL-27-induced T-bet expression but not proliferation of naive CD4+ T cells.

Kamiya S, Owaki T, Morishima N, Fukai F, Mizuguchi J, Yoshimoto T.

J Immunol. 2004 Sep 15;173(6):3871-7.


A role for IL-27 in early regulation of Th1 differentiation.

Owaki T, Asakawa M, Morishima N, Hata K, Fukai F, Matsui M, Mizuguchi J, Yoshimoto T.

J Immunol. 2005 Aug 15;175(4):2191-200.


Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10.

Gerosa F, Paganin C, Peritt D, Paiola F, Scupoli MT, Aste-Amezaga M, Frank I, Trinchieri G.

J Exp Med. 1996 Jun 1;183(6):2559-69.


Development of Th1-type immune responses requires the type I cytokine receptor TCCR.

Chen Q, Ghilardi N, Wang H, Baker T, Xie MH, Gurney A, Grewal IS, de Sauvage FJ.

Nature. 2000 Oct 19;407(6806):916-20.


IL-27 signaling compromises control of bacterial growth in mycobacteria-infected mice.

Pearl JE, Khader SA, Solache A, Gilmartin L, Ghilardi N, deSauvage F, Cooper AM.

J Immunol. 2004 Dec 15;173(12):7490-6.


The secreted form of p28 subunit of interleukin (IL)-27 inhibits biological functions of IL-27 and suppresses anti-allogeneic immune responses.

Shimozato O, Sato A, Kawamura K, Chiyo M, Ma G, Li Q, Tagawa M.

Immunology. 2009 Sep;128(1 Suppl):e816-25. doi: 10.1111/j.1365-2567.2009.03088.x.


IFN-gamma production by Th1 cells generated from naive CD4+ T cells exposed to norepinephrine.

Swanson MA, Lee WT, Sanders VM.

J Immunol. 2001 Jan 1;166(1):232-40. Erratum in: J Immunol 2001 Jun 1;166(11):6992.


Polarization of IL-4- and IFN-gamma-producing CD4+ T cells following activation of naive CD4+ T cells.

Nakamura T, Kamogawa Y, Bottomly K, Flavell RA.

J Immunol. 1997 Feb 1;158(3):1085-94.

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