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Items: 1 to 20 of 99

1.

Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition.

Shimuta K, Nakajo N, Uto K, Hayano Y, Okazaki K, Sagata N.

EMBO J. 2002 Jul 15;21(14):3694-703.

2.

Altered expression of Chk1 disrupts cell cycle remodeling at the midblastula transition in Xenopus laevis embryos.

Petrus MJ, Wilhelm DE, Murakami M, Kappas NC, Carter AD, Wroble BN, Sible JC.

Cell Cycle. 2004 Feb;3(2):212-7.

PMID:
14712091
3.
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6.

Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism.

Uto K, Inoue D, Shimuta K, Nakajo N, Sagata N.

EMBO J. 2004 Aug 18;23(16):3386-96. Epub 2004 Jul 22.

7.

The extracellular signal-regulated kinase-mitogen-activated protein kinase pathway phosphorylates and targets Cdc25A for SCF beta-TrCP-dependent degradation for cell cycle arrest.

Isoda M, Kanemori Y, Nakajo N, Uchida S, Yamashita K, Ueno H, Sagata N.

Mol Biol Cell. 2009 Apr;20(8):2186-95. doi: 10.1091/mbc.E09-01-0008. Epub 2009 Feb 25.

8.

Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase.

Jin J, Ang XL, Ye X, Livingstone M, Harper JW.

J Biol Chem. 2008 Jul 11;283(28):19322-8. doi: 10.1074/jbc.M802474200. Epub 2008 May 13.

10.

SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase.

Jin J, Shirogane T, Xu L, Nalepa G, Qin J, Elledge SJ, Harper JW.

Genes Dev. 2003 Dec 15;17(24):3062-74. Epub 2003 Dec 17.

11.

Beta-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases.

Kanemori Y, Uto K, Sagata N.

Proc Natl Acad Sci U S A. 2005 May 3;102(18):6279-84. Epub 2005 Apr 21.

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Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint.

Goloudina A, Yamaguchi H, Chervyakova DB, Appella E, Fornace AJ Jr, Bulavin DV.

Cell Cycle. 2003 Sep-Oct;2(5):473-8.

PMID:
12963847
14.

DNA damage-induced degradation of Cdc25A does not lead to inhibition of Cdk2 activity in mouse embryonic stem cells.

Koledova Z, Kafkova LR, Krämer A, Divoky V.

Stem Cells. 2010 Mar 31;28(3):450-61. doi: 10.1002/stem.311.

15.

[Degradation of Cdc25A phosphatase in HeLa cells under normal and stress conditions].

Goloudina AR, Aksenov ND, Pospelov VA.

Tsitologiia. 2004;46(5):423-30. Russian.

PMID:
15344887
16.

Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents.

Xiao Z, Chen Z, Gunasekera AH, Sowin TJ, Rosenberg SH, Fesik S, Zhang H.

J Biol Chem. 2003 Jun 13;278(24):21767-73. Epub 2003 Apr 3.

17.

ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage.

Sørensen CS, Syljuåsen RG, Lukas J, Bartek J.

Cell Cycle. 2004 Jul;3(7):941-5. Epub 2004 Jul 13.

PMID:
15190204
18.

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

Sørensen CS, Syljuåsen RG, Falck J, Schroeder T, Rönnstrand L, Khanna KK, Zhou BB, Bartek J, Lukas J.

Cancer Cell. 2003 Mar;3(3):247-58.

19.

Dual regulation of Cdc25A by Chk1 and p53-ATF3 in DNA replication checkpoint control.

Demidova AR, Aau MY, Zhuang L, Yu Q.

J Biol Chem. 2009 Feb 13;284(7):4132-9. doi: 10.1074/jbc.M808118200. Epub 2008 Dec 7.

20.

Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding.

Chen MS, Ryan CE, Piwnica-Worms H.

Mol Cell Biol. 2003 Nov;23(21):7488-97.

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