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mu-Opioid receptors: Ligand-dependent activation of potassium conductance, desensitization, and internalization.

Alvarez VA, Arttamangkul S, Dang V, Salem A, Whistler JL, Von Zastrow M, Grandy DK, Williams JT.

J Neurosci. 2002 Jul 1;22(13):5769-76.


Mu-opioid receptor desensitization in mature rat neurons: lack of interaction between DAMGO and morphine.

Bailey CP, Couch D, Johnson E, Griffiths K, Kelly E, Henderson G.

J Neurosci. 2003 Nov 19;23(33):10515-20.


Enhancement of μ-opioid receptor desensitization by nitric oxide in rat locus coeruleus neurons: involvement of reactive oxygen species.

Llorente J, Santamarta MT, Henderson G, Pineda J.

J Pharmacol Exp Ther. 2012 Aug;342(2):552-60. doi: 10.1124/jpet.112.194225.


Neurokinin 1 receptors regulate morphine-induced endocytosis and desensitization of mu-opioid receptors in CNS neurons.

Yu YJ, Arttamangkul S, Evans CJ, Williams JT, von Zastrow M.

J Neurosci. 2009 Jan 7;29(1):222-33. doi: 10.1523/JNEUROSCI.4315-08.2009.


Enhancement of morphine analgesic effect with induction of mu-opioid receptor endocytosis in rats.

Hashimoto T, Saito Y, Yamada K, Hara N, Kirihara Y, Tsuchiya M.

Anesthesiology. 2006 Sep;105(3):574-80.


Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization, and endocytosis of mu-opioid receptors.

Borgland SL, Connor M, Osborne PB, Furness JB, Christie MJ.

J Biol Chem. 2003 May 23;278(21):18776-84.


Agonist-selective endocytosis of mu opioid receptor by neurons in vivo.

Sternini C, Spann M, Anton B, Keith DE Jr, Bunnett NW, von Zastrow M, Evans C, Brecha NC.

Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9241-6.


Differential activation and trafficking of micro-opioid receptors in brain slices.

Arttamangkul S, Quillinan N, Low MJ, von Zastrow M, Pintar J, Williams JT.

Mol Pharmacol. 2008 Oct;74(4):972-9. doi: 10.1124/mol.108.048512.


Agonist-specific regulation of mu-opioid receptor desensitization and recovery from desensitization.

Virk MS, Williams JT.

Mol Pharmacol. 2008 Apr;73(4):1301-8. doi: 10.1124/mol.107.042952.


Desensitization of functional µ-opioid receptors increases agonist off-rate.

Williams JT.

Mol Pharmacol. 2014 Jul;86(1):52-61. doi: 10.1124/mol.114.092098.


Mu-opioid receptor redistribution in the locus coeruleus upon precipitation of withdrawal in opiate-dependent rats.

Scavone JL, Van Bockstaele EJ.

Anat Rec (Hoboken). 2009 Mar;292(3):401-11. doi: 10.1002/ar.20860.


Mechanisms of rapid opioid receptor desensitization, resensitization and tolerance in brain neurons.

Dang VC, Christie MJ.

Br J Pharmacol. 2012 Mar;165(6):1704-16. doi: 10.1111/j.1476-5381.2011.01482.x. Review.


Contribution of nitric oxide-dependent guanylate cyclase and reactive oxygen species signaling pathways to desensitization of μ-opioid receptors in the rat locus coeruleus.

Pablos P, Mendiguren A, Pineda J.

Neuropharmacology. 2015 Dec;99:422-31. doi: 10.1016/j.neuropharm.2015.08.004.


Buprenorphine is a weak partial agonist that inhibits opioid receptor desensitization.

Virk MS, Arttamangkul S, Birdsong WT, Williams JT.

J Neurosci. 2009 Jun 3;29(22):7341-8. doi: 10.1523/JNEUROSCI.3723-08.2009.

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