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An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer.

Tanabe O, Katsuoka F, Campbell AD, Song W, Yamamoto M, Tanimoto K, Engel JD.

EMBO J. 2002 Jul 1;21(13):3434-42.


Embryonic and fetal beta-globin gene repression by the orphan nuclear receptors, TR2 and TR4.

Tanabe O, McPhee D, Kobayashi S, Shen Y, Brandt W, Jiang X, Campbell AD, Chen YT, Chang Cs, Yamamoto M, Tanimoto K, Engel JD.

EMBO J. 2007 May 2;26(9):2295-306. Epub 2007 Apr 12.


Compound loss of function of nuclear receptors Tr2 and Tr4 leads to induction of murine embryonic β-type globin genes.

Cui S, Tanabe O, Sierant M, Shi L, Campbell A, Lim KC, Engel JD.

Blood. 2015 Feb 26;125(9):1477-87. doi: 10.1182/blood-2014-10-605022. Epub 2015 Jan 5.


Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells.

Cui S, Kolodziej KE, Obara N, Amaral-Psarris A, Demmers J, Shi L, Engel JD, Grosveld F, Strouboulis J, Tanabe O.

Mol Cell Biol. 2011 Aug;31(16):3298-311. doi: 10.1128/MCB.05310-11. Epub 2011 Jun 13.


The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription.

Tanabe O, Shen Y, Liu Q, Campbell AD, Kuroha T, Yamamoto M, Engel JD.

Genes Dev. 2007 Nov 1;21(21):2832-44.


Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes.

Campbell AD, Cui S, Shi L, Urbonya R, Mathias A, Bradley K, Bonsu KO, Douglas RR, Halford B, Schmidt L, Harro D, Giacherio D, Tanimoto K, Tanabe O, Engel JD.

Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18808-13. doi: 10.1073/pnas.1104964108. Epub 2011 Oct 31.


Sequences located 3' to the breakpoint of the hereditary persistence of fetal hemoglobin-3 deletion exhibit enhancer activity and can modify the developmental expression of the human fetal A gamma-globin gene in transgenic mice.

Anagnou NP, Perez-Stable C, Gelinas R, Costantini F, Liapaki K, Constantopoulou M, Kosteas T, Moschonas NK, Stamatoyannopoulos G.

J Biol Chem. 1995 Apr 28;270(17):10256-63.


Heme positively regulates the expression of beta-globin at the locus control region via the transcriptional factor Bach1 in erythroid cells.

Tahara T, Sun J, Nakanishi K, Yamamoto M, Mori H, Saito T, Fujita H, Igarashi K, Taketani S.

J Biol Chem. 2004 Feb 13;279(7):5480-7. Epub 2003 Dec 1.


Expression of the human gamma-globin gene after retroviral transfer to transformed erythroid cells.

Rixon MW, Harris EA, Gelinas RE.

Biochemistry. 1990 May 8;29(18):4393-400.


Developmental specificity of recruitment of TBP to the TATA box of the human gamma-globin gene.

Duan ZJ, Fang X, Rohde A, Han H, Stamatoyannopoulos G, Li Q.

Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5509-14.


[Functional analysis of human A gamma-globin gene promoter with-173 T-->C mutation].

Huang X, Zhang J, Yang X, Wang Y, Zhao H.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1999 Aug;21(4):252-6. Chinese.


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