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Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma.

Weeraratna AT, Jiang Y, Hostetter G, Rosenblatt K, Duray P, Bittner M, Trent JM.

Cancer Cell. 2002 Apr;1(3):279-88.


WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells.

Ekström EJ, Bergenfelz C, von Bülow V, Serifler F, Carlemalm E, Jönsson G, Andersson T, Leandersson K.

Mol Cancer. 2014 Apr 26;13:88. doi: 10.1186/1476-4598-13-88.


A t-butyloxycarbonyl-modified Wnt5a-derived hexapeptide functions as a potent antagonist of Wnt5a-dependent melanoma cell invasion.

Jenei V, Sherwood V, Howlin J, Linnskog R, Säfholm A, Axelsson L, Andersson T.

Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19473-8. doi: 10.1073/pnas.0909409106. Epub 2009 Nov 9.


Importance of P-cadherin, beta-catenin, and Wnt5a/frizzled for progression of melanocytic tumors and prognosis in cutaneous melanoma.

Bachmann IM, Straume O, Puntervoll HE, Kalvenes MB, Akslen LA.

Clin Cancer Res. 2005 Dec 15;11(24 Pt 1):8606-14.


Constitutive activation of Wnt/beta-catenin signaling pathway in migration-active melanoma cells: role of LEF-1 in melanoma with increased metastatic potential.

Murakami T, Toda S, Fujimoto M, Ohtsuki M, Byers HR, Etoh T, Nakagawa H.

Biochem Biophys Res Commun. 2001 Oct 19;288(1):8-15.


Wnt5A activates the calpain-mediated cleavage of filamin A.

O'Connell MP, Fiori JL, Baugher KM, Indig FE, French AD, Camilli TC, Frank BP, Earley R, Hoek KS, Hasskamp JH, Elias EG, Taub DD, Bernier M, Weeraratna AT.

J Invest Dermatol. 2009 Jul;129(7):1782-9. doi: 10.1038/jid.2008.433. Epub 2009 Jan 29.


Heparan sulfate proteoglycan modulation of Wnt5A signal transduction in metastatic melanoma cells.

O'Connell MP, Fiori JL, Kershner EK, Frank BP, Indig FE, Taub DD, Hoek KS, Weeraratna AT.

J Biol Chem. 2009 Oct 16;284(42):28704-12. doi: 10.1074/jbc.M109.028498. Epub 2009 Aug 20.


Phenylmethimazole decreases Toll-like receptor 3 and noncanonical Wnt5a expression in pancreatic cancer and melanoma together with tumor cell growth and migration.

Schwartz AL, Malgor R, Dickerson E, Weeraratna AT, Slominski A, Wortsman J, Harii N, Kohn AD, Moon RT, Schwartz FL, Goetz DJ, Kohn LD, McCall KD.

Clin Cancer Res. 2009 Jun 15;15(12):4114-22. doi: 10.1158/1078-0432.CCR-09-0005. Epub 2009 May 26.


The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition.

Dissanayake SK, Wade M, Johnson CE, O'Connell MP, Leotlela PD, French AD, Shah KV, Hewitt KJ, Rosenthal DT, Indig FE, Jiang Y, Nickoloff BJ, Taub DD, Trent JM, Moon RT, Bittner M, Weeraratna AT.

J Biol Chem. 2007 Jun 8;282(23):17259-71. Epub 2007 Apr 10.


SKI activates Wnt/beta-catenin signaling in human melanoma.

Chen D, Xu W, Bales E, Colmenares C, Conacci-Sorrell M, Ishii S, Stavnezer E, Campisi J, Fisher DE, Ben-Ze'ev A, Medrano EE.

Cancer Res. 2003 Oct 15;63(20):6626-34.


Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling.

Enomoto M, Hayakawa S, Itsukushima S, Ren DY, Matsuo M, Tamada K, Oneyama C, Okada M, Takumi T, Nishita M, Minami Y.

Oncogene. 2009 Sep 10;28(36):3197-208. doi: 10.1038/onc.2009.175. Epub 2009 Jun 29.


[Preparation of the recombinant lentiviral expression vector targeting human Wnt5a gene and its inhibitory effect on melanoma cell invasion].

Zhao Y, Miao Y, Chen X, Wang L, Lu F, Liao W.

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014 May;30(5):462-5. Chinese.


The small GTPase ARF6 stimulates β-catenin transcriptional activity during WNT5A-mediated melanoma invasion and metastasis.

Grossmann AH, Yoo JH, Clancy J, Sorensen LK, Sedgwick A, Tong Z, Ostanin K, Rogers A, Grossmann KF, Tripp SR, Thomas KR, D'Souza-Schorey C, Odelberg SJ, Li DY.

Sci Signal. 2013 Mar 5;6(265):ra14. doi: 10.1126/scisignal.2003398.


Assaying Wnt5A-mediated invasion in melanoma cells.

O'Connell MP, French AD, Leotlela PD, Weeraratna AT.

Methods Mol Biol. 2008;468:243-53. doi: 10.1007/978-1-59745-249-6_19.


The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma.

O'Connell MP, Fiori JL, Xu M, Carter AD, Frank BP, Camilli TC, French AD, Dissanayake SK, Indig FE, Bernier M, Taub DD, Hewitt SM, Weeraratna AT.

Oncogene. 2010 Jan 7;29(1):34-44. doi: 10.1038/onc.2009.305. Epub 2009 Oct 5.


Interleukin-6 drives melanoma cell motility through p38α-MAPK-dependent up-regulation of WNT5A expression.

Linnskog R, Jönsson G, Axelsson L, Prasad CP, Andersson T.

Mol Oncol. 2014 Dec;8(8):1365-78. doi: 10.1016/j.molonc.2014.05.008. Epub 2014 May 27.


Wnt5a is strongly expressed at the leading edge in non-melanoma skin cancer, forming active gradients, while canonical Wnt signalling is repressed.

Pourreyron C, Reilly L, Proby C, Panteleyev A, Fleming C, McLean K, South AP, Foerster J.

PLoS One. 2012;7(2):e31827. doi: 10.1371/journal.pone.0031827. Epub 2012 Feb 22.


Wnt5a promotes human colon cancer cell migration and invasion but does not augment intestinal tumorigenesis in Apc1638N mice.

Bakker ER, Das AM, Helvensteijn W, Franken PF, Swagemakers S, van der Valk MA, ten Hagen TL, Kuipers EJ, van Veelen W, Smits R.

Carcinogenesis. 2013 Nov;34(11):2629-38. doi: 10.1093/carcin/bgt215. Epub 2013 Jun 12.


Wnt5a induces endothelial inflammation via beta-catenin-independent signaling.

Kim J, Kim J, Kim DW, Ha Y, Ihm MH, Kim H, Song K, Lee I.

J Immunol. 2010 Jul 15;185(2):1274-82. doi: 10.4049/jimmunol.1000181. Epub 2010 Jun 16.


Loss of membranous expression of beta-catenin is associated with tumor progression in cutaneous melanoma and rarely caused by exon 3 mutations.

Demunter A, Libbrecht L, Degreef H, De Wolf-Peeters C, van den Oord JJ.

Mod Pathol. 2002 Apr;15(4):454-61.

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