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The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas.

Zhang P, McGrath B, Li S, Frank A, Zambito F, Reinert J, Gannon M, Ma K, McNaughton K, Cavener DR.

Mol Cell Biol. 2002 Jun;22(11):3864-74.


PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis.

Gao Y, Sartori DJ, Li C, Yu QC, Kushner JA, Simon MC, Diehl JA.

Mol Cell Biol. 2012 Dec;32(24):5129-39. doi: 10.1128/MCB.01009-12. Epub 2012 Oct 15.


PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice.

Iida K, Li Y, McGrath BC, Frank A, Cavener DR.

BMC Cell Biol. 2007 Aug 29;8:38.


PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway.

Gupta S, McGrath B, Cavener DR.

Diabetes. 2010 Aug;59(8):1937-47. doi: 10.2337/db09-1064. Epub 2010 Jun 8.


PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver.

Li Y, Iida K, O'Neil J, Zhang P, Li S, Frank A, Gabai A, Zambito F, Liang SH, Rosen CJ, Cavener DR.

Endocrinology. 2003 Aug;144(8):3505-13.


Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival.

Harding HP, Zeng H, Zhang Y, Jungries R, Chung P, Plesken H, Sabatini DD, Ron D.

Mol Cell. 2001 Jun;7(6):1153-63.


PERK is essential for neonatal skeletal development to regulate osteoblast proliferation and differentiation.

Wei J, Sheng X, Feng D, McGrath B, Cavener DR.

J Cell Physiol. 2008 Dec;217(3):693-707. doi: 10.1002/jcp.21543.


Uncoupling proteostasis and development in vitro with a small molecule inhibitor of the pancreatic endoplasmic reticulum kinase, PERK.

Harding HP, Zyryanova AF, Ron D.

J Biol Chem. 2012 Dec 28;287(53):44338-44. doi: 10.1074/jbc.M112.428987. Epub 2012 Nov 12.


Type I interferons mediate pancreatic toxicities of PERK inhibition.

Yu Q, Zhao B, Gui J, Katlinski KV, Brice A, Gao Y, Li C, Kushner JA, Koumenis C, Diehl JA, Fuchs SY.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15420-5. doi: 10.1073/pnas.1516362112. Epub 2015 Dec 1.


Wolcott-Rallison syndrome.

Julier C, Nicolino M.

Orphanet J Rare Dis. 2010 Nov 4;5:29. doi: 10.1186/1750-1172-5-29. Review.


Endoplasmic reticulum stress response mediated by the PERK-eIF2(alpha)-ATF4 pathway is involved in osteoblast differentiation induced by BMP2.

Saito A, Ochiai K, Kondo S, Tsumagari K, Murakami T, Cavener DR, Imaizumi K.

J Biol Chem. 2011 Feb 11;286(6):4809-18. doi: 10.1074/jbc.M110.152900. Epub 2010 Dec 6.


PERK activation at low glucose concentration is mediated by SERCA pump inhibition and confers preemptive cytoprotection to pancreatic β-cells.

Moore CE, Omikorede O, Gomez E, Willars GB, Herbert TP.

Mol Endocrinol. 2011 Feb;25(2):315-26. doi: 10.1210/me.2010-0309. Epub 2010 Dec 30.


Dual function of pancreatic endoplasmic reticulum kinase in tumor cell growth arrest and survival.

Ranganathan AC, Ojha S, Kourtidis A, Conklin DS, Aguirre-Ghiso JA.

Cancer Res. 2008 May 1;68(9):3260-8. doi: 10.1158/0008-5472.CAN-07-6215.


Microscopic and ultrastructural features in Wolcott-Rallison syndrome, a permanent neonatal diabetes mellitus: about two autopsy cases.

Collardeau-Frachon S, Vasiljevic A, Jouvet A, Bouvier R, Senée V, Nicolino M.

Pediatr Diabetes. 2015 Nov;16(7):510-20. doi: 10.1111/pedi.12201. Epub 2014 Aug 18.


PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway.

Hamanaka RB, Bennett BS, Cullinan SB, Diehl JA.

Mol Biol Cell. 2005 Dec;16(12):5493-501. Epub 2005 Sep 21.


Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation.

Feng D, Wei J, Gupta S, McGrath BC, Cavener DR.

BMC Cell Biol. 2009 Sep 4;10:61. doi: 10.1186/1471-2121-10-61.


The antipsychotic olanzapine induces apoptosis in insulin-secreting pancreatic β cells by blocking PERK-mediated translational attenuation.

Ozasa R, Okada T, Nadanaka S, Nagamine T, Zyryanova A, Harding H, Ron D, Mori K.

Cell Struct Funct. 2013;38(2):183-95. Epub 2013 Jun 28. Erratum in: Cell Struct Funct. 2014;39(1):21. Cell Struct Funct. 2013;38(2):227.

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