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Neurofibromas in NF1: Schwann cell origin and role of tumor environment.

Zhu Y, Ghosh P, Charnay P, Burns DK, Parada LF.

Science. 2002 May 3;296(5569):920-2.


Loss of NF1 allele in Schwann cells but not in fibroblasts derived from an NF1-associated neurofibroma.

Kluwe L, Friedrich R, Mautner VF.

Genes Chromosomes Cancer. 1999 Mar;24(3):283-5.


Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesis.

Ling BC, Wu J, Miller SJ, Monk KR, Shamekh R, Rizvi TA, Decourten-Myers G, Vogel KS, DeClue JE, Ratner N.

Cancer Cell. 2005 Jan;7(1):65-75.


Susceptible stages in Schwann cells for NF1-associated plexiform neurofibroma development.

Le LQ, Liu C, Shipman T, Chen Z, Suter U, Parada LF.

Cancer Res. 2011 Jul 1;71(13):4686-95. doi: 10.1158/0008-5472.CAN-10-4577. Epub 2011 May 6.


Molecular, genetic, and cellular pathogenesis of neurofibromas and surgical implications.

Gottfried ON, Viskochil DH, Fults DW, Couldwell WT.

Neurosurgery. 2006 Jan;58(1):1-16; discussion 1-16. Review.


The angiogenic factor midkine is aberrantly expressed in NF1-deficient Schwann cells and is a mitogen for neurofibroma-derived cells.

Mashour GA, Ratner N, Khan GA, Wang HL, Martuza RL, Kurtz A.

Oncogene. 2001 Jan 4;20(1):97-105.


Schwann cells harbor the somatic NF1 mutation in neurofibromas: evidence of two different Schwann cell subpopulations.

Serra E, Rosenbaum T, Winner U, Aledo R, Ars E, Estivill X, Lenard HG, Lázaro C.

Hum Mol Genet. 2000 Dec 12;9(20):3055-64.


Specific expression of the neurofibromatosis type 1 gene (NF1) in the hamster Schwann cell.

Nakamura T, Nemoto T, Arai M, Yamazaki Y, Kasuga T, Gutmann DH, Collins FS, Ishikawa T.

Am J Pathol. 1994 Mar;144(3):549-55.


The activation of the WNT signaling pathway is a Hallmark in neurofibromatosis type 1 tumorigenesis.

Luscan A, Shackleford G, Masliah-Planchon J, Laurendeau I, Ortonne N, Varin J, Lallemand F, Leroy K, Dumaine V, Hivelin M, Borderie D, De Raedt T, Valeyrie-Allanore L, Larousserie F, Terris B, Lantieri L, Vidaud M, Vidaud D, Wolkenstein P, Parfait B, Bièche I, Massaad C, Pasmant E.

Clin Cancer Res. 2014 Jan 15;20(2):358-71. doi: 10.1158/1078-0432.CCR-13-0780. Epub 2013 Nov 11.


Angiogenic and invasive properties of neurofibroma Schwann cells.

Sheela S, Riccardi VM, Ratner N.

J Cell Biol. 1990 Aug;111(2):645-53.


How does the Schwann cell lineage form tumors in NF1?

Carroll SL, Ratner N.

Glia. 2008 Nov 1;56(14):1590-605. doi: 10.1002/glia.20776. Review.


S100B and neurofibromin immunostaining and X-inactivation patterns of laser-microdissected cells indicate a multicellular origin of some NF1-associated neurofibromas.

Tucker T, Riccardi VM, Brown C, Fee J, Sutcliffe M, Vielkind J, Wechsler J, Wolkenstein P, Friedman JM.

J Neurosci Res. 2011 Sep;89(9):1451-60. doi: 10.1002/jnr.22654. Epub 2011 Jun 14.


Injury signals cooperate with Nf1 loss to relieve the tumor-suppressive environment of adult peripheral nerve.

Ribeiro S, Napoli I, White IJ, Parrinello S, Flanagan AM, Suter U, Parada LF, Lloyd AC.

Cell Rep. 2013 Oct 17;5(1):126-36. doi: 10.1016/j.celrep.2013.08.033. Epub 2013 Sep 26.


Mouse models of tumor development in neurofibromatosis type 1.

Cichowski K, Shih TS, Schmitt E, Santiago S, Reilly K, McLaughlin ME, Bronson RT, Jacks T.

Science. 1999 Dec 10;286(5447):2172-6.


Mitotic recombination effects homozygosity for NF1 germline mutations in neurofibromas.

Serra E, Rosenbaum T, Nadal M, Winner U, Ars E, Estivill X, Lázaro C.

Nat Genet. 2001 Jul;28(3):294-6. Erratum in: Nat Genet 2001 Sep;29(1):100.


Mouse tumor model for neurofibromatosis type 1.

Vogel KS, Klesse LJ, Velasco-Miguel S, Meyers K, Rushing EJ, Parada LF.

Science. 1999 Dec 10;286(5447):2176-9.


Chromosome 17 loss-of-heterozygosity studies in benign and malignant tumors in neurofibromatosis type 1.

Rasmussen SA, Overman J, Thomson SA, Colman SD, Abernathy CR, Trimpert RE, Moose R, Virdi G, Roux K, Bauer M, Rojiani AM, Maria BL, Muir D, Wallace MR.

Genes Chromosomes Cancer. 2000 Aug;28(4):425-31.


Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-beta signaling.

Yang FC, Chen S, Clegg T, Li X, Morgan T, Estwick SA, Yuan J, Khalaf W, Burgin S, Travers J, Parada LF, Ingram DA, Clapp DW.

Hum Mol Genet. 2006 Aug 15;15(16):2421-37. Epub 2006 Jul 11.

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