Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 145

1.
2.
3.
4.
6.

UCN-01 induces S and G2/M cell cycle arrest through the p53/p21(waf1) or CHK2/CDC25C pathways and can suppress invasion in human hepatoma cell lines.

Wu G, Lin N, Xu L, Liu B, Feitelson MA.

BMC Cancer. 2013 Mar 28;13:167. doi: 10.1186/1471-2407-13-167. Erratum in: BMC Cancer. 2014;14:216. Feitelson, Mark A [added].

7.

The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01.

Graves PR, Yu L, Schwarz JK, Gales J, Sausville EA, O'Connor PM, Piwnica-Worms H.

J Biol Chem. 2000 Feb 25;275(8):5600-5.

8.
10.

Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.

Hutchins JR, Dikovskaya D, Clarke PR.

Mol Biol Cell. 2003 Oct;14(10):4003-14. Epub 2003 Jul 11. Erratum in: Mol Biol Cell. 2005 Mar;16(3):1568.

12.

Chk1 instability is coupled to mitotic cell death of p53-deficient cells in response to virus-induced DNA damage signaling.

Jurvansuu J, Fragkos M, Ingemarsdotter C, Beard P.

J Mol Biol. 2007 Sep 14;372(2):397-406. Epub 2007 Jul 3.

PMID:
17663993
13.
15.

UCN-01 selectively enhances mitomycin C cytotoxicity in p53 defective cells which is mediated through S and/or G(2) checkpoint abrogation.

Sugiyama K, Shimizu M, Akiyama T, Tamaoki T, Yamaguchi K, Takahashi R, Eastman A, Akinaga S.

Int J Cancer. 2000 Mar 1;85(5):703-9.

16.

Dual regulation of Cdc25A by Chk1 and p53-ATF3 in DNA replication checkpoint control.

Demidova AR, Aau MY, Zhuang L, Yu Q.

J Biol Chem. 2009 Feb 13;284(7):4132-9. doi: 10.1074/jbc.M808118200. Epub 2008 Dec 7.

17.

The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1.

Busby EC, Leistritz DF, Abraham RT, Karnitz LM, Sarkaria JN.

Cancer Res. 2000 Apr 15;60(8):2108-12.

18.

UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.

Wang Q, Fan S, Eastman A, Worland PJ, Sausville EA, O'Connor PM.

J Natl Cancer Inst. 1996 Jul 17;88(14):956-65.

PMID:
8667426
19.

Supplemental Content

Support Center