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Items: 1 to 20 of 111

1.

Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand.

Xiong JP, Stehle T, Zhang R, Joachimiak A, Frech M, Goodman SL, Arnaout MA.

Science. 2002 Apr 5;296(5565):151-5. Epub 2002 Mar 7.

2.

Crystal structure of the extracellular segment of integrin alpha Vbeta3.

Xiong JP, Stehle T, Diefenbach B, Zhang R, Dunker R, Scott DL, Joachimiak A, Goodman SL, Arnaout MA.

Science. 2001 Oct 12;294(5541):339-45. Epub 2001 Sep 6.

3.

Coming to grips with integrin binding to ligands.

Arnaout MA, Goodman SL, Xiong JP.

Curr Opin Cell Biol. 2002 Oct;14(5):641-51. Review.

PMID:
12231361
4.

Synthesis, SAR and in vitro evaluation of new cyclic Arg-Gly-Asp pseudopentapeptides containing a s-cis peptide bond as integrin alphavbeta3 and alphavbeta5 ligands.

Salvati M, Cordero FM, Pisaneschi F, Melani F, Gratteri P, Cini N, Bottoncetti A, Brandi A.

Bioorg Med Chem. 2008 Apr 15;16(8):4262-71. doi: 10.1016/j.bmc.2008.02.080. Epub 2008 Feb 29.

PMID:
18343671
5.

Site-specific inhibition of integrin alpha v beta 3-vitronectin association by a ser-asp-val sequence through an Arg-Gly-Asp-binding site of the integrin.

Choi Y, Kim E, Lee Y, Han MH, Kang IC.

Proteomics. 2010 Jan;10(1):72-80. doi: 10.1002/pmic.200900146.

PMID:
19882657
6.

Divalent cations and the relationship between alphaA and betaA domains in integrins.

Seow KT, Xiong JP, Arnaout MA, Welge J, Rippmann F, Goodman SL.

Biochem Pharmacol. 2002 Sep;64(5-6):805-12.

PMID:
12213573
7.

Identification of the principal binding site for RGD-containing ligands in the alpha(V)beta(3) integrin: a photoaffinity cross-linking study.

Yahalom D, Wittelsberger A, Mierke DF, Rosenblatt M, Alexander JM, Chorev M.

Biochemistry. 2002 Jul 2;41(26):8321-31.

PMID:
12081480
8.

Morpholine-based RGD-cyclopentapeptides as alphavbeta3/alphavbeta5 integrin ligands: role of configuration towards receptor binding affinity.

Cini N, Trabocchi A, Menchi G, Bottoncetti A, Raspanti S, Pupi A, Guarna A.

Bioorg Med Chem. 2009 Feb 15;17(4):1542-9. doi: 10.1016/j.bmc.2009.01.006. Epub 2009 Jan 13.

PMID:
19195898
9.

The chemokine fractalkine can activate integrins without CX3CR1 through direct binding to a ligand-binding site distinct from the classical RGD-binding site.

Fujita M, Takada YK, Takada Y.

PLoS One. 2014 May 2;9(5):e96372. doi: 10.1371/journal.pone.0096372. eCollection 2014.

11.

Biological and molecular properties of a new alpha(v)beta3/alpha(v)beta5 integrin antagonist.

Belvisi L, Riccioni T, Marcellini M, Vesci L, Chiarucci I, Efrati D, Potenza D, Scolastico C, Manzoni L, Lombardo K, Stasi MA, Orlandi A, Ciucci A, Nico B, Ribatti D, Giannini G, Presta M, Carminati P, Pisano C.

Mol Cancer Ther. 2005 Nov;4(11):1670-80.

12.

The α-subunit regulates stability of the metal ion at the ligand-associated metal ion-binding site in β3 integrins.

Rui X, Mehrbod M, Van Agthoven JF, Anand S, Xiong JP, Mofrad MR, Arnaout MA.

J Biol Chem. 2014 Aug 15;289(33):23256-63. doi: 10.1074/jbc.M114.581470. Epub 2014 Jun 28.

13.

Cyclic RGD peptidomimetics containing bifunctional diketopiperazine scaffolds as new potent integrin ligands.

Marchini M, Mingozzi M, Colombo R, Guzzetti I, Belvisi L, Vasile F, Potenza D, Piarulli U, Arosio D, Gennari C.

Chemistry. 2012 May 14;18(20):6195-207. doi: 10.1002/chem.201200457. Epub 2012 Apr 19.

PMID:
22517378
14.

Mapping the integrin alpha V beta 3-ligand interface by photoaffinity cross-linking.

Bitan G, Scheibler L, Greenberg Z, Rosenblatt M, Chorev M.

Biochemistry. 1999 Mar 16;38(11):3414-20.

PMID:
10079087
15.

Molecular determinants of arg-gly-asp ligand specificity for beta3 integrins.

Kunicki TJ, Annis DS, Felding-Habermann B.

J Biol Chem. 1997 Feb 14;272(7):4103-7.

16.
17.

Immunosuppressory activity of the cyclodimeric peptide with RGD-sequences.

Szewczuk Z, Buczek P, Stefanowicz P, Krajewski K, Wieczorek Z, Siemion IZ.

Acta Biochim Pol. 2001;48(1):121-30.

18.

Cation-dependent changes in the binding specificity of the platelet receptor GPIIb/IIIa.

Kirchhofer D, Gailit J, Ruoslahti E, Grzesiak J, Pierschbacher MD.

J Biol Chem. 1990 Oct 25;265(30):18525-30.

19.

Atomic basis for the species-specific inhibition of αV integrins by monoclonal antibody 17E6 is revealed by the crystal structure of αVβ3 ectodomain-17E6 Fab complex.

Mahalingam B, Van Agthoven JF, Xiong JP, Alonso JL, Adair BD, Rui X, Anand S, Mehrbod M, Mofrad MR, Burger C, Goodman SL, Arnaout MA.

J Biol Chem. 2014 May 16;289(20):13801-9. doi: 10.1074/jbc.M113.546929. Epub 2014 Apr 1.

20.

Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders.

Casiraghi G, Rassu G, Auzzas L, Burreddu P, Gaetani E, Battistini L, Zanardi F, Curti C, Nicastro G, Belvisi L, Motto I, Castorina M, Giannini G, Pisano C.

J Med Chem. 2005 Dec 1;48(24):7675-87.

PMID:
16302808

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