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Items: 1 to 20 of 158

1.

Accelerated cardiomyopathy in mice with overexpression of cardiac G(s)alpha and a missense mutation in the alpha-myosin heavy chain.

Hardt SE, Geng YJ, Montagne O, Asai K, Hong C, Yang GP, Bishop SP, Kim SJ, Vatner DE, Seidman CE, Seidman JG, Homcy CJ, Vatner SF.

Circulation. 2002 Feb 5;105(5):614-20.

2.

An alpha-cardiac myosin heavy chain gene mutation impairs contraction and relaxation function of cardiac myocytes.

Kim SJ, Iizuka K, Kelly RA, Geng YJ, Bishop SP, Yang G, Kudej A, McConnell BK, Seidman CE, Seidman JG, Vatner SF.

Am J Physiol. 1999 May;276(5 Pt 2):H1780-7.

3.

Morphological and functional alterations in ventricular myocytes from male transgenic mice with hypertrophic cardiomyopathy.

Olsson MC, Palmer BM, Stauffer BL, Leinwand LA, Moore RL.

Circ Res. 2004 Feb 6;94(2):201-7. Epub 2003 Dec 11.

4.

Overexpressed cardiac Gsalpha in rabbits.

Nishizawa T, Vatner SF, Hong C, Shen YT, Hardt SE, Robbins J, Ishikawa Y, Sadoshima J, Vatner DE.

J Mol Cell Cardiol. 2006 Jul;41(1):44-50. Epub 2006 May 5.

PMID:
16678849
5.

Depressed heart rate variability and arterial baroreflex in conscious transgenic mice with overexpression of cardiac Gsalpha.

Uechi M, Asai K, Osaka M, Smith A, Sato N, Wagner TE, Ishikawa Y, Hayakawa H, Vatner DE, Shannon RP, Homcy CJ, Vatner SF.

Circ Res. 1998 Mar 9;82(4):416-23.

6.

A polymorphic modifier gene alters the hypertrophic response in a murine model of familial hypertrophic cardiomyopathy.

Semsarian C, Healey MJ, Fatkin D, Giewat M, Duffy C, Seidman CE, Seidman JG.

J Mol Cell Cardiol. 2001 Nov;33(11):2055-60.

PMID:
11708849
7.

Volume overload cardiac hypertrophy exhibits decreased expression of g(s)alpha and not of g(i)alpha in heart.

Di Fusco F, Hashim S, Anand-Srivastava MB.

Am J Physiol Cell Physiol. 2000 Oct;279(4):C990-8.

8.

Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity.

Rajan S, Ahmed RP, Jagatheesan G, Petrashevskaya N, Boivin GP, Urboniene D, Arteaga GM, Wolska BM, Solaro RJ, Liggett SB, Wieczorek DF.

Circ Res. 2007 Jul 20;101(2):205-14. Epub 2007 Jun 7. Erratum in: Circ Res. 2007 Sep 14;101(6):e80.

9.

Overexpression of myocardial Gsalpha prevents full expression of catecholamine desensitization despite increased beta-adrenergic receptor kinase.

Vatner DE, Asai K, Iwase M, Ishikawa Y, Wagner TE, Shannon RP, Homcy CJ, Vatner SF.

J Clin Invest. 1998 May 1;101(9):1916-22.

10.

Cardiomyopathy induced by cardiac Gs alpha overexpression.

Iwase M, Uechi M, Vatner DE, Asai K, Shannon RP, Kudej RK, Wagner TE, Wight DC, Patrick TA, Ishikawa Y, Homcy CJ, Vatner SF.

Am J Physiol. 1997 Jan;272(1 Pt 2):H585-9.

PMID:
9038982
11.

Hypertrophy, fibrosis, and sudden cardiac death in response to pathological stimuli in mice with mutations in cardiac troponin T.

Maass AH, Ikeda K, Oberdorf-Maass S, Maier SK, Leinwand LA.

Circulation. 2004 Oct 12;110(15):2102-9. Epub 2004 Oct 4.

12.

Adverse effects of chronic endogenous sympathetic drive induced by cardiac GS alpha overexpression.

Iwase M, Bishop SP, Uechi M, Vatner DE, Shannon RP, Kudej RK, Wight DC, Wagner TE, Ishikawa Y, Homcy CJ, Vatner SF.

Circ Res. 1996 Apr;78(4):517-24.

13.

The pathogenesis of familial hypertrophic cardiomyopathy: early and evolving effects from an alpha-cardiac myosin heavy chain missense mutation.

Georgakopoulos D, Christe ME, Giewat M, Seidman CM, Seidman JG, Kass DA.

Nat Med. 1999 Mar;5(3):327-30.

PMID:
10086390
14.

Preserved ventricular contractility in infarcted mouse heart overexpressing beta(2)-adrenergic receptors.

Du XJ, Gao XM, Jennings GL, Dart AM, Woodcock EA.

Am J Physiol Heart Circ Physiol. 2000 Nov;279(5):H2456-63.

15.

Cardiac myosin heavy chains lacking the light chain binding domain cause hypertrophic cardiomyopathy in mice.

Welikson RE, Buck SH, Patel JR, Moss RL, Vikstrom KL, Factor SM, Miyata S, Weinberger HD, Leinwand LA.

Am J Physiol. 1999 Jun;276(6 Pt 2):H2148-58.

16.

Severe heart failure and early mortality in a double-mutation mouse model of familial hypertrophic cardiomyopathy.

Tsoutsman T, Kelly M, Ng DC, Tan JE, Tu E, Lam L, Bogoyevitch MA, Seidman CE, Seidman JG, Semsarian C.

Circulation. 2008 Apr 8;117(14):1820-31. doi: 10.1161/CIRCULATIONAHA.107.755777. Epub 2008 Mar 24.

17.

Gender and aging in a transgenic mouse model of hypertrophic cardiomyopathy.

Olsson MC, Palmer BM, Leinwand LA, Moore RL.

Am J Physiol Heart Circ Physiol. 2001 Mar;280(3):H1136-44.

18.

Myofilament mechanical performance is enhanced by R403Q myosin in mouse myocardium independent of sex.

Palmer BM, Wang Y, Teekakirikul P, Hinson JT, Fatkin D, Strouse S, Vanburen P, Seidman CE, Seidman JG, Maughan DW.

Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1939-47. doi: 10.1152/ajpheart.00644.2007. Epub 2008 Feb 15.

19.

The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse model.

Semsarian C, Ahmad I, Giewat M, Georgakopoulos D, Schmitt JP, McConnell BK, Reiken S, Mende U, Marks AR, Kass DA, Seidman CE, Seidman JG.

J Clin Invest. 2002 Apr;109(8):1013-20.

20.

Cardiac S100A1 protein levels determine contractile performance and propensity toward heart failure after myocardial infarction.

Most P, Seifert H, Gao E, Funakoshi H, Völkers M, Heierhorst J, Remppis A, Pleger ST, DeGeorge BR Jr, Eckhart AD, Feldman AM, Koch WJ.

Circulation. 2006 Sep 19;114(12):1258-68. Epub 2006 Sep 4.

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