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Items: 1 to 20 of 103

1.

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.

Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S.

Nat Immunol. 2002 Feb;3(2):196-200. Epub 2002 Jan 22.

PMID:
11812998
2.

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.

Yamamoto M, Sato S, Hemmi H, Sanjo H, Uematsu S, Kaisho T, Hoshino K, Takeuchi O, Kobayashi M, Fujita T, Takeda K, Akira S.

Nature. 2002 Nov 21;420(6913):324-9.

PMID:
12447441
3.

Endotoxin-induced maturation of MyD88-deficient dendritic cells.

Kaisho T, Takeuchi O, Kawai T, Hoshino K, Akira S.

J Immunol. 2001 May 1;166(9):5688-94.

4.

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors.

Horng T, Barton GM, Flavell RA, Medzhitov R.

Nature. 2002 Nov 21;420(6913):329-33.

PMID:
12447442
6.

The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily.

Heil F, Ahmad-Nejad P, Hemmi H, Hochrein H, Ampenberger F, Gellert T, Dietrich H, Lipford G, Takeda K, Akira S, Wagner H, Bauer S.

Eur J Immunol. 2003 Nov;33(11):2987-97.

7.

Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor 4.

Doyle SE, O'Connell R, Vaidya SA, Chow EK, Yee K, Cheng G.

J Immunol. 2003 Apr 1;170(7):3565-71.

9.

Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP.

Andreakos E, Sacre SM, Smith C, Lundberg A, Kiriakidis S, Stonehouse T, Monaco C, Feldmann M, Foxwell BM.

Blood. 2004 Mar 15;103(6):2229-37. Epub 2003 Nov 20.

10.

Differential induction of the toll-like receptor 4-MyD88-dependent and -independent signaling pathways by endotoxins.

Zughaier SM, Zimmer SM, Datta A, Carlson RW, Stephens DS.

Infect Immun. 2005 May;73(5):2940-50. Erratum in: Infect Immun. 2006 May;74(5):3077.

11.

Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction.

Uematsu S, Sato S, Yamamoto M, Hirotani T, Kato H, Takeshita F, Matsuda M, Coban C, Ishii KJ, Kawai T, Takeuchi O, Akira S.

J Exp Med. 2005 Mar 21;201(6):915-23. Epub 2005 Mar 14.

12.

Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6.

H├Ącker H, Vabulas RM, Takeuchi O, Hoshino K, Akira S, Wagner H.

J Exp Med. 2000 Aug 21;192(4):595-600.

13.

Recognition of single-stranded RNA viruses by Toll-like receptor 7.

Lund JM, Alexopoulou L, Sato A, Karow M, Adams NC, Gale NW, Iwasaki A, Flavell RA.

Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5598-603. Epub 2004 Mar 19.

14.

Plasmacytoid dendritic cells produce cytokines and mature in response to the TLR7 agonists, imiquimod and resiquimod.

Gibson SJ, Lindh JM, Riter TR, Gleason RM, Rogers LM, Fuller AE, Oesterich JL, Gorden KB, Qiu X, McKane SW, Noelle RJ, Miller RL, Kedl RM, Fitzgerald-Bocarsly P, Tomai MA, Vasilakos JP.

Cell Immunol. 2002 Jul-Aug;218(1-2):74-86.

PMID:
12470615
15.

The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.

Schoenemeyer A, Barnes BJ, Mancl ME, Latz E, Goutagny N, Pitha PM, Fitzgerald KA, Golenbock DT.

J Biol Chem. 2005 Apr 29;280(17):17005-12. Epub 2005 Jan 28.

16.

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway.

Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi O, Sugiyama M, Okabe M, Takeda K, Akira S.

Science. 2003 Aug 1;301(5633):640-3. Epub 2003 Jul 10.

17.

TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway.

Yamamoto M, Sato S, Hemmi H, Uematsu S, Hoshino K, Kaisho T, Takeuchi O, Takeda K, Akira S.

Nat Immunol. 2003 Nov;4(11):1144-50. Epub 2003 Oct 12.

18.

Differential involvement of IFN-beta in Toll-like receptor-stimulated dendritic cell activation.

Hoshino K, Kaisho T, Iwabe T, Takeuchi O, Akira S.

Int Immunol. 2002 Oct;14(10):1225-31.

PMID:
12356687
19.

Transforming growth factor-beta differentially inhibits MyD88-dependent, but not TRAM- and TRIF-dependent, lipopolysaccharide-induced TLR4 signaling.

Naiki Y, Michelsen KS, Zhang W, Chen S, Doherty TM, Arditi M.

J Biol Chem. 2005 Feb 18;280(7):5491-5. Epub 2004 Dec 28.

20.

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.

Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C.

Science. 2004 Mar 5;303(5663):1529-31. Epub 2004 Feb 19.

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