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Function of GB1 and GB2 subunits in G protein coupling of GABA(B) receptors.

Margeta-Mitrovic M, Jan YN, Jan LY.

Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14649-54. Epub 2001 Nov 27.


Ligand-induced signal transduction within heterodimeric GABA(B) receptor.

Margeta-Mitrovic M, Jan YN, Jan LY.

Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14643-8. Epub 2001 Nov 27.


The intracellular loops of the GB2 subunit are crucial for G-protein coupling of the heteromeric gamma-aminobutyrate B receptor.

Havlickova M, Prezeau L, Duthey B, Bettler B, Pin JP, Blahos J.

Mol Pharmacol. 2002 Aug;62(2):343-50.


Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function.

Galvez T, Duthey B, Kniazeff J, Blahos J, Rovelli G, Bettler B, Prézeau L, Pin JP.

EMBO J. 2001 May 1;20(9):2152-9.


Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor.

Sullivan R, Chateauneuf A, Coulombe N, Kolakowski LF Jr, Johnson MP, Hebert TE, Ethier N, Belley M, Metters K, Abramovitz M, O'Neill GP, Ng GY.

J Pharmacol Exp Ther. 2000 May;293(2):460-7.


A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptor.

Duthey B, Caudron S, Perroy J, Bettler B, Fagni L, Pin JP, Prézeau L.

J Biol Chem. 2002 Feb 1;277(5):3236-41. Epub 2001 Nov 15.


Importance of the gamma-aminobutyric acid(B) receptor C-termini for G-protein coupling.

Grünewald S, Schupp BJ, Ikeda SR, Kuner R, Steigerwald F, Kornau HC, Köhr G.

Mol Pharmacol. 2002 May;61(5):1070-80.


Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity.

Ng GY, Clark J, Coulombe N, Ethier N, Hebert TE, Sullivan R, Kargman S, Chateauneuf A, Tsukamoto N, McDonald T, Whiting P, Mezey E, Johnson MP, Liu Q, Kolakowski LF Jr, Evans JF, Bonner TI, O'Neill GP.

J Biol Chem. 1999 Mar 19;274(12):7607-10.


Distribution of the GABA(B) receptor subunit gb2 in rat CNS.

Clark JA, Mezey E, Lam AS, Bonner TI.

Brain Res. 2000 Mar 31;860(1-2):41-52.


The C-terminal domains of the GABA(b) receptor subunits mediate intracellular trafficking but are not required for receptor signaling.

Calver AR, Robbins MJ, Cosio C, Rice SQ, Babbs AJ, Hirst WD, Boyfield I, Wood MD, Russell RB, Price GW, Couve A, Moss SJ, Pangalos MN.

J Neurosci. 2001 Feb 15;21(4):1203-10.


Molecular determinants involved in the allosteric control of agonist affinity in the GABAB receptor by the GABAB2 subunit.

Liu J, Maurel D, Etzol S, Brabet I, Ansanay H, Pin JP, Rondard P.

J Biol Chem. 2004 Apr 16;279(16):15824-30. Epub 2004 Jan 21.


Agonist-induced desensitization and endocytosis of heterodimeric GABAB receptors in CHO-K1 cells.

González-Maeso J, Wise A, Green A, Koenig JA.

Eur J Pharmacol. 2003 Nov 14;481(1):15-23.


GABA(B2) is essential for g-protein coupling of the GABA(B) receptor heterodimer.

Robbins MJ, Calver AR, Filippov AK, Hirst WD, Russell RB, Wood MD, Nasir S, Couve A, Brown DA, Moss SJ, Pangalos MN.

J Neurosci. 2001 Oct 15;21(20):8043-52.


The second intracellular loop of metabotropic glutamate receptors recognizes C termini of G-protein alpha-subunits.

Havlickova M, Blahos J, Brabet I, Liu J, Hruskova B, Prézeau L, Pin JP.

J Biol Chem. 2003 Sep 12;278(37):35063-70. Epub 2003 Jun 26.


The heteromeric GABA-B receptor recognizes G-protein alpha subunit C-termini.

Franek M, Pagano A, Kaupmann K, Bettler B, Pin JP, Blahos J.

Neuropharmacology. 1999 Nov;38(11):1657-66.


Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action.

Ng GY, Bertrand S, Sullivan R, Ethier N, Wang J, Yergey J, Belley M, Trimble L, Bateman K, Alder L, Smith A, McKernan R, Metters K, O'Neill GP, Lacaille JC, Hébert TE.

Mol Pharmacol. 2001 Jan;59(1):144-52.


C-terminal interaction is essential for surface trafficking but not for heteromeric assembly of GABA(b) receptors.

Pagano A, Rovelli G, Mosbacher J, Lohmann T, Duthey B, Stauffer D, Ristig D, Schuler V, Meigel I, Lampert C, Stein T, Prezeau L, Blahos J, Pin J, Froestl W, Kuhn R, Heid J, Kaupmann K, Bettler B.

J Neurosci. 2001 Feb 15;21(4):1189-202.


A trafficking checkpoint controls GABA(B) receptor heterodimerization.

Margeta-Mitrovic M, Jan YN, Jan LY.

Neuron. 2000 Jul;27(1):97-106.

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