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Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex.

Krugmann S, Jordens I, Gevaert K, Driessens M, Vandekerckhove J, Hall A.

Curr Biol. 2001 Oct 30;11(21):1645-55.


The Cdc42 effector IRSp53 generates filopodia by coupling membrane protrusion with actin dynamics.

Lim KB, Bu W, Goh WI, Koh E, Ong SH, Pawson T, Sudhaharan T, Ahmed S.

J Biol Chem. 2008 Jul 18;283(29):20454-72. doi: 10.1074/jbc.M710185200. Epub 2008 Apr 29.


A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein.

Yamagishi A, Masuda M, Ohki T, Onishi H, Mochizuki N.

J Biol Chem. 2004 Apr 9;279(15):14929-36. Epub 2004 Jan 29.


Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex.

Disanza A, Mantoani S, Hertzog M, Gerboth S, Frittoli E, Steffen A, Berhoerster K, Kreienkamp HJ, Milanesi F, Di Fiore PP, Ciliberto A, Stradal TE, Scita G.

Nat Cell Biol. 2006 Dec;8(12):1337-47. Epub 2006 Nov 19.


The mammalian verprolin, WIRE induces filopodia independent of N-WASP through IRSp53.

Misra A, Rajmohan R, Lim RP, Bhattacharyya S, Thanabalu T.

Exp Cell Res. 2010 Oct 15;316(17):2810-24. doi: 10.1016/j.yexcr.2010.07.015. Epub 2010 Aug 1.


The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42.

Soltau M, Richter D, Kreienkamp HJ.

Mol Cell Neurosci. 2002 Dec;21(4):575-83.


N-WASP, WAVE and Mena play different roles in the organization of actin cytoskeleton in lamellipodia.

Nakagawa H, Miki H, Ito M, Ohashi K, Takenawa T, Miyamoto S.

J Cell Sci. 2001 Apr;114(Pt 8):1555-65.


Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth.

Abe T, Kato M, Miki H, Takenawa T, Endo T.

J Cell Sci. 2003 Jan 1;116(Pt 1):155-68.


IRSp53 is colocalised with WAVE2 at the tips of protruding lamellipodia and filopodia independently of Mena.

Nakagawa H, Miki H, Nozumi M, Takenawa T, Miyamoto S, Wehland J, Small JV.

J Cell Sci. 2003 Jun 15;116(Pt 12):2577-83. Epub 2003 May 6.


Rif-mDia1 interaction is involved in filopodium formation independent of Cdc42 and Rac effectors.

Goh WI, Sudhaharan T, Lim KB, Sem KP, Lau CL, Ahmed S.

J Biol Chem. 2011 Apr 15;286(15):13681-94. doi: 10.1074/jbc.M110.182683. Epub 2011 Feb 21.


mDia1 and WAVE2 proteins interact directly with IRSp53 in filopodia and are involved in filopodium formation.

Goh WI, Lim KB, Sudhaharan T, Sem KP, Bu W, Chou AM, Ahmed S.

J Biol Chem. 2012 Feb 10;287(7):4702-14. doi: 10.1074/jbc.M111.305102. Epub 2011 Dec 17.


Regulation of IRSp53-dependent filopodial dynamics by antagonism between 14-3-3 binding and SH3-mediated localization.

Robens JM, Yeow-Fong L, Ng E, Hall C, Manser E.

Mol Cell Biol. 2010 Feb;30(3):829-44. doi: 10.1128/MCB.01574-08. Epub 2009 Nov 23.


I-BAR domains, IRSp53 and filopodium formation.

Ahmed S, Goh WI, Bu W.

Semin Cell Dev Biol. 2010 Jun;21(4):350-6. doi: 10.1016/j.semcdb.2009.11.008. Epub 2009 Nov 11. Review.


Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors.

Kast DJ, Yang C, Disanza A, Boczkowska M, Madasu Y, Scita G, Svitkina T, Dominguez R.

Nat Struct Mol Biol. 2014 Apr;21(4):413-22. doi: 10.1038/nsmb.2781. Epub 2014 Mar 2.


IRSp53 mediates podosome formation via VASP in NIH-Src cells.

Oikawa T, Okamura H, Dietrich F, Senju Y, Takenawa T, Suetsugu S.

PLoS One. 2013;8(3):e60528. doi: 10.1371/journal.pone.0060528. Epub 2013 Mar 26.


Optimization of WAVE2 complex-induced actin polymerization by membrane-bound IRSp53, PIP(3), and Rac.

Suetsugu S, Kurisu S, Oikawa T, Yamazaki D, Oda A, Takenawa T.

J Cell Biol. 2006 May 22;173(4):571-85. Epub 2006 May 15.


Regulation of dendritic spine morphogenesis by insulin receptor substrate 53, a downstream effector of Rac1 and Cdc42 small GTPases.

Choi J, Ko J, Racz B, Burette A, Lee JR, Kim S, Na M, Lee HW, Kim K, Weinberg RJ, Kim E.

J Neurosci. 2005 Jan 26;25(4):869-79.


MALS is a binding partner of IRSp53 at cell-cell contacts.

Hori K, Konno D, Maruoka H, Sobue K.

FEBS Lett. 2003 Nov 6;554(1-2):30-4.


ProSAP/Shank postsynaptic density proteins interact with insulin receptor tyrosine kinase substrate IRSp53.

Bockmann J, Kreutz MR, Gundelfinger ED, Böckers TM.

J Neurochem. 2002 Nov;83(4):1013-7.

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