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Signaling through adenylyl cyclase is essential for hyphal growth and virulence in the pathogenic fungus Candida albicans.

Rocha CR, Schröppel K, Harcus D, Marcil A, Dignard D, Taylor BN, Thomas DY, Whiteway M, Leberer E.

Mol Biol Cell. 2001 Nov;12(11):3631-43.


Ras links cellular morphogenesis to virulence by regulation of the MAP kinase and cAMP signalling pathways in the pathogenic fungus Candida albicans.

Leberer E, Harcus D, Dignard D, Johnson L, Ushinsky S, Thomas DY, Schröppel K.

Mol Microbiol. 2001 Nov;42(3):673-87.


Virulence and hyphal formation of Candida albicans require the Ste20p-like protein kinase CaCla4p.

Leberer E, Ziegelbauer K, Schmidt A, Harcus D, Dignard D, Ash J, Johnson L, Thomas DY.

Curr Biol. 1997 Aug 1;7(8):539-46.


The TEA/ATTS transcription factor CaTec1p regulates hyphal development and virulence in Candida albicans.

Schweizer A, Rupp S, Taylor BN, Röllinghoff M, Schröppel K.

Mol Microbiol. 2000 Nov;38(3):435-45.


Calcineurin is essential for virulence in Candida albicans.

Bader T, Bodendorfer B, Schröppel K, Morschhäuser J.

Infect Immun. 2003 Sep;71(9):5344-54.


Transcriptional regulators Cph1p and Efg1p mediate activation of the Candida albicans virulence gene SAP5 during infection.

Staib P, Kretschmar M, Nichterlein T, Hof H, Morschhäuser J.

Infect Immun. 2002 Feb;70(2):921-7.


The Flo8 transcription factor is essential for hyphal development and virulence in Candida albicans.

Cao F, Lane S, Raniga PP, Lu Y, Zhou Z, Ramon K, Chen J, Liu H.

Mol Biol Cell. 2006 Jan;17(1):295-307. Epub 2005 Nov 2.


Ssn6, an important factor of morphological conversion and virulence in Candida albicans.

Hwang CS, Oh JH, Huh WK, Yim HS, Kang SO.

Mol Microbiol. 2003 Feb;47(4):1029-43.


Retigeric acid B attenuates the virulence of Candida albicans via inhibiting adenylyl cyclase activity targeted by enhanced farnesol production.

Chang W, Li Y, Zhang L, Cheng A, Lou H.

PLoS One. 2012;7(7):e41624. doi: 10.1371/journal.pone.0041624. Epub 2012 Jul 23.


The Set3/Hos2 histone deacetylase complex attenuates cAMP/PKA signaling to regulate morphogenesis and virulence of Candida albicans.

Hnisz D, Majer O, Frohner IE, Komnenovic V, Kuchler K.

PLoS Pathog. 2010 May 13;6(5):e1000889. doi: 10.1371/journal.ppat.1000889.


Derepressed hyphal growth and reduced virulence in a VH1 family-related protein phosphatase mutant of the human pathogen Candida albicans.

Csank C, Makris C, Meloche S, Schröppel K, Röllinghoff M, Dignard D, Thomas DY, Whiteway M.

Mol Biol Cell. 1997 Dec;8(12):2539-51.


Candida albicans AGE3, the ortholog of the S. cerevisiae ARF-GAP-encoding gene GCS1, is required for hyphal growth and drug resistance.

Lettner T, Zeidler U, Gimona M, Hauser M, Breitenbach M, Bito A.

PLoS One. 2010 Aug 5;5(8):e11993. doi: 10.1371/journal.pone.0011993.


Protein kinase A encoded by TPK2 regulates dimorphism of Candida albicans.

Sonneborn A, Bockmühl DP, Gerads M, Kurpanek K, Sanglard D, Ernst JF.

Mol Microbiol. 2000 Jan;35(2):386-96.


Hgc1, a novel hypha-specific G1 cyclin-related protein regulates Candida albicans hyphal morphogenesis.

Zheng X, Wang Y, Wang Y.

EMBO J. 2004 Apr 21;23(8):1845-56. Epub 2004 Apr 8.


Linking cellular actin status with cAMP signaling in Candida albicans.

Wang Y, Zou H, Fang HM, Zhu Y.

Virulence. 2010 May-Jun;1(3):202-5. doi: 10.4161/viru.1.3.11836.


Candida albicans Sfl2, a temperature-induced transcriptional regulator, is required for virulence in a murine gastrointestinal infection model.

Song W, Wang H, Chen J.

FEMS Yeast Res. 2011 Mar;11(2):209-22. doi: 10.1111/j.1567-1364.2010.00710.x. Epub 2011 Jan 14.


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