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Items: 1 to 20 of 462

1.
2.

Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.

Wellington CL, Ellerby LM, Gutekunst CA, Rogers D, Warby S, Graham RK, Loubser O, van Raamsdonk J, Singaraja R, Yang YZ, Gafni J, Bredesen D, Hersch SM, Leavitt BR, Roy S, Nicholson DW, Hayden MR.

J Neurosci. 2002 Sep 15;22(18):7862-72.

3.
4.

Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.

Hermel E, Gafni J, Propp SS, Leavitt BR, Wellington CL, Young JE, Hackam AS, Logvinova AV, Peel AL, Chen SF, Hook V, Singaraja R, Krajewski S, Goldsmith PC, Ellerby HM, Hayden MR, Bredesen DE, Ellerby LM.

Cell Death Differ. 2004 Apr;11(4):424-38.

5.

Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus.

Gafni J, Hermel E, Young JE, Wellington CL, Hayden MR, Ellerby LM.

J Biol Chem. 2004 May 7;279(19):20211-20.

6.

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.

Graham RK, Deng Y, Slow EJ, Haigh B, Bissada N, Lu G, Pearson J, Shehadeh J, Bertram L, Murphy Z, Warby SC, Doty CN, Roy S, Wellington CL, Leavitt BR, Raymond LA, Nicholson DW, Hayden MR.

Cell. 2006 Jun 16;125(6):1179-91.

7.

Huntingtin is degraded to small fragments by calpain after ischemic injury.

Kim M, Roh JK, Yoon BW, Kang L, Kim YJ, Aronin N, DiFiglia M.

Exp Neurol. 2003 Sep;183(1):109-15.

PMID:
12957494
8.

Comparison of huntingtin proteolytic fragments in human lymphoblast cell lines and human brain.

Toneff T, Mende-Mueller L, Wu Y, Hwang SR, Bundey R, Thompson LM, Chesselet MF, Hook V.

J Neurochem. 2002 Jul;82(1):84-92.

9.

Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity.

Luo S, Vacher C, Davies JE, Rubinsztein DC.

J Cell Biol. 2005 May 23;169(4):647-56.

10.

Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative.

Tebbenkamp AT, Green C, Xu G, Denovan-Wright EM, Rising AC, Fromholt SE, Brown HH, Swing D, Mandel RJ, Tessarollo L, Borchelt DR.

Hum Mol Genet. 2011 Jul 15;20(14):2770-82. doi: 10.1093/hmg/ddr176.

11.

Calpain cleaved-55kDa N-terminal huntingtin delocalizes from neurons to astrocytes after ischemic injury.

Kim SC, Chung JY, Im W, Kim M, Kim M.

Cell Mol Biol (Noisy-le-grand). 2011 Jul 27;57 Suppl:OL1534-42.

PMID:
21791172
12.

Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease.

Zhang H, Li Q, Graham RK, Slow E, Hayden MR, Bezprozvanny I.

Neurobiol Dis. 2008 Jul;31(1):80-8. doi: 10.1016/j.nbd.2008.03.010.

13.

Aggregation in Huntington's disease: insights through modelling.

Cajavec B, Bernard S, Herzel H.

Genome Inform. 2005;16(1):262-71.

PMID:
16362929
15.

Olesoxime suppresses calpain activation and mutant huntingtin fragmentation in the BACHD rat.

Clemens LE, Weber JJ, Wlodkowski TT, Yu-Taeger L, Michaud M, Calaminus C, Eckert SH, Gaca J, Weiss A, Magg JC, Jansson EK, Eckert GP, Pichler BJ, Bordet T, Pruss RM, Riess O, Nguyen HP.

Brain. 2015 Dec;138(Pt 12):3632-53. doi: 10.1093/brain/awv290.

PMID:
26490331
16.

Calpain activation in Huntington's disease.

Gafni J, Ellerby LM.

J Neurosci. 2002 Jun 15;22(12):4842-9.

17.

Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment.

Gafni J, Papanikolaou T, Degiacomo F, Holcomb J, Chen S, Menalled L, Kudwa A, Fitzpatrick J, Miller S, Ramboz S, Tuunanen PI, Lehtimäki KK, Yang XW, Park L, Kwak S, Howland D, Park H, Ellerby LM.

J Neurosci. 2012 May 30;32(22):7454-65. doi: 10.1523/JNEUROSCI.6379-11.2012.

18.

Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin.

Tanaka Y, Igarashi S, Nakamura M, Gafni J, Torcassi C, Schilling G, Crippen D, Wood JD, Sawa A, Jenkins NA, Copeland NG, Borchelt DR, Ross CA, Ellerby LM.

Neurobiol Dis. 2006 Feb;21(2):381-91.

PMID:
16150600
19.

N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking.

Orr AL, Li S, Wang CE, Li H, Wang J, Rong J, Xu X, Mastroberardino PG, Greenamyre JT, Li XJ.

J Neurosci. 2008 Mar 12;28(11):2783-92. doi: 10.1523/JNEUROSCI.0106-08.2008.

20.

Autophagy regulates the processing of amino terminal huntingtin fragments.

Qin ZH, Wang Y, Kegel KB, Kazantsev A, Apostol BL, Thompson LM, Yoder J, Aronin N, DiFiglia M.

Hum Mol Genet. 2003 Dec 15;12(24):3231-44.

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