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Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr.

Vines CM, Potter JW, Xu Y, Geahlen RL, Costello PS, Tybulewicz VL, Lowell CA, Chang PW, Gresham HD, Willman CL.

Immunity. 2001 Oct;15(4):507-19.


Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages.

Suen PW, Ilic D, Caveggion E, Berton G, Damsky CH, Lowell CA.

J Cell Sci. 1999 Nov;112 ( Pt 22):4067-78.


Role of Src kinases and Syk in Fcgamma receptor-mediated phagocytosis and phagosome-lysosome fusion.

Majeed M, Caveggion E, Lowell CA, Berton G.

J Leukoc Biol. 2001 Nov;70(5):801-11.


Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck.

Mócsai A, Ligeti E, Lowell CA, Berton G.

J Immunol. 1999 Jan 15;162(2):1120-6.


PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling.

Zarbock A, Abram CL, Hundt M, Altman A, Lowell CA, Ley K.

J Exp Med. 2008 Sep 29;205(10):2339-47. doi: 10.1084/jem.20072660. Epub 2008 Sep 15.


Differential involvement of Src family kinases in Fc gamma receptor-mediated phagocytosis.

Suzuki T, Kono H, Hirose N, Okada M, Yamamoto T, Yamamoto K, Honda Z.

J Immunol. 2000 Jul 1;165(1):473-82.


Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn.

Fitzer-Attas CJ, Lowry M, Crowley MT, Finn AJ, Meng F, DeFranco AL, Lowell CA.

J Exp Med. 2000 Feb 21;191(4):669-82.


Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton.

Obergfell A, Eto K, Mocsai A, Buensuceso C, Moores SL, Brugge JS, Lowell CA, Shattil SJ.

J Cell Biol. 2002 Apr 15;157(2):265-75. Epub 2002 Apr 8.


CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion.

Roach T, Slater S, Koval M, White L, Cahir McFarland ED, Okumura M, Thomas M, Brown E.

Curr Biol. 1997 Jun 1;7(6):408-17.


Syk is required for integrin signaling in neutrophils.

Mócsai A, Zhou M, Meng F, Tybulewicz VL, Lowell CA.

Immunity. 2002 Apr;16(4):547-58.


A role for Syk-kinase in the control of the binding cycle of the beta2 integrins (CD11/CD18) in human polymorphonuclear neutrophils.

Willeke T, Schymeinsky J, Prange P, Zahler S, Walzog B.

J Leukoc Biol. 2003 Aug;74(2):260-9.


Pre-T cell receptor signals are responsible for the down-regulation of Syk protein tyrosine kinase expression.

Chu DH, van Oers NS, Malissen M, Harris J, Elder M, Weiss A.

J Immunol. 1999 Sep 1;163(5):2610-20.

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