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Items: 1 to 20 of 112


hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.

Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, Pandita TK, Guarente L, Weinberg RA.

Cell. 2001 Oct 19;107(2):149-59.


Human Sir2 and the 'silencing' of p53 activity.

Smith J.

Trends Cell Biol. 2002 Sep;12(9):404-6.


ING1 represses transcription by direct DNA binding and through effects on p53.

Kataoka H, Bonnefin P, Vieyra D, Feng X, Hara Y, Miura Y, Joh T, Nakabayashi H, Vaziri H, Harris CC, Riabowol K.

Cancer Res. 2003 Sep 15;63(18):5785-92.


The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene.

Lagger G, Doetzlhofer A, Schuettengruber B, Haidweger E, Simboeck E, Tischler J, Chiocca S, Suske G, Rotheneder H, Wintersberger E, Seiser C.

Mol Cell Biol. 2003 Apr;23(8):2669-79.


Negative control of p53 by Sir2alpha promotes cell survival under stress.

Luo J, Nikolaev AY, Imai S, Chen D, Su F, Shiloh A, Guarente L, Gu W.

Cell. 2001 Oct 19;107(2):137-48.


H2O2 accelerates cellular senescence by accumulation of acetylated p53 via decrease in the function of SIRT1 by NAD+ depletion.

Furukawa A, Tada-Oikawa S, Kawanishi S, Oikawa S.

Cell Physiol Biochem. 2007;20(1-4):45-54.


Activation of p53 by protein inhibitor of activated Stat1 (PIAS1).

Megidish T, Xu JH, Xu CW.

J Biol Chem. 2002 Mar 8;277(10):8255-9.


Necdin regulates p53 acetylation via Sirtuin1 to modulate DNA damage response in cortical neurons.

Hasegawa K, Yoshikawa K.

J Neurosci. 2008 Aug 27;28(35):8772-84. doi: 10.1523/JNEUROSCI.3052-08.2008.


DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter.

St Clair S, Giono L, Varmeh-Ziaie S, Resnick-Silverman L, Liu WJ, Padi A, Dastidar J, DaCosta A, Mattia M, Manfredi JJ.

Mol Cell. 2004 Dec 3;16(5):725-36.


Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses.

Chen WY, Wang DH, Yen RC, Luo J, Gu W, Baylin SB.

Cell. 2005 Nov 4;123(3):437-48.


A novel chalcone polyphenol inhibits the deacetylase activity of SIRT1 and cell growth in HEK293T cells.

Kahyo T, Ichikawa S, Hatanaka T, Yamada MK, Setou M.

J Pharmacol Sci. 2008 Nov;108(3):364-71.


A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.

Smith JS, Brachmann CB, Celic I, Kenna MA, Muhammad S, Starai VJ, Avalos JL, Escalante-Semerena JC, Grubmeyer C, Wolberger C, Boeke JD.

Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6658-63.


Conserved enzymatic production and biological effect of O-acetyl-ADP-ribose by silent information regulator 2-like NAD+-dependent deacetylases.

Borra MT, O'Neill FJ, Jackson MD, Marshall B, Verdin E, Foltz KR, Denu JM.

J Biol Chem. 2002 Apr 12;277(15):12632-41.


p53-dependent down-regulation of telomerase is mediated by p21waf1.

Shats I, Milyavsky M, Tang X, Stambolsky P, Erez N, Brosh R, Kogan I, Braunstein I, Tzukerman M, Ginsberg D, Rotter V.

J Biol Chem. 2004 Dec 3;279(49):50976-85.


Tumor suppressor p53 mediates apoptotic cell death triggered by cyclosporin A.

Pyrzynska B, Serrano M, Martínez-A C, Kaminska B.

J Biol Chem. 2002 Apr 19;277(16):14102-8.


Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage.

Wang C, Chen L, Hou X, Li Z, Kabra N, Ma Y, Nemoto S, Finkel T, Gu W, Cress WD, Chen J.

Nat Cell Biol. 2006 Sep;8(9):1025-31.


Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.

Mujtaba S, He Y, Zeng L, Yan S, Plotnikova O, Sachchidanand, Sanchez R, Zeleznik-Le NJ, Ronai Z, Zhou MM.

Mol Cell. 2004 Jan 30;13(2):251-63.


Acetylation of Sirt2 by p300 attenuates its deacetylase activity.

Han Y, Jin YH, Kim YJ, Kang BY, Choi HJ, Kim DW, Yeo CY, Lee KY.

Biochem Biophys Res Commun. 2008 Oct 31;375(4):576-80. doi: 10.1016/j.bbrc.2008.08.042.


A novel eIF5A complex functions as a regulator of p53 and p53-dependent apoptosis.

Li AL, Li HY, Jin BF, Ye QN, Zhou T, Yu XD, Pan X, Man JH, He K, Yu M, Hu MR, Wang J, Yang SC, Shen BF, Zhang XM.

J Biol Chem. 2004 Nov 19;279(47):49251-8.

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