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Human Rad17 is phosphorylated upon DNA damage and also overexpressed in primary non-small cell lung cancer tissues.

Wang X, Wang L, Callister MD, Putnam JB, Mao L, Li L.

Cancer Res. 2001 Oct 15;61(20):7417-21.


HRad17, a human homologue of the Schizosaccharomyces pombe checkpoint gene rad17, is overexpressed in colon carcinoma.

Bao S, Chang MS, Auclair D, Sun Y, Wang Y, Wong WK, Zhang J, Liu Y, Qian X, Sutherland R, Magi-Galluzi C, Weisberg E, Cheng EY, Hao L, Sasaki H, Campbell MS, Kraeft SK, Loda M, Lo KM, Chen LB.

Cancer Res. 1999 May 1;59(9):2023-8.


Overexpression of Hrad17 gene in non-small cell lung cancers correlated with lymph node metastasis.

Sasaki H, Chen LB, Auclair D, Moriyama S, Kaji M, Fukai I, Kiriyama M, Yamakawa Y, Fujii Y.

Lung Cancer. 2001 Oct;34(1):47-52.


hRAD17, a structural homolog of the Schizosaccharomyces pombe RAD17 cell cycle checkpoint gene, stimulates p53 accumulation.

Li L, Peterson CA, Kanter-Smoler G, Wei YF, Ramagli LS, Sunnerhagen P, Siciliano MJ, Legerski RJ.

Oncogene. 1999 Mar 4;18(9):1689-99.


Identification of a human homologue of the Schizosaccharomyces pombe rad17+ checkpoint gene.

Parker AE, Van de Weyer I, Laus MC, Verhasselt P, Luyten WH.

J Biol Chem. 1998 Jul 17;273(29):18340-6. Erratum in: J Biol Chem 1999 Aug 20;274(34):24438.


HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation.

Chang MS, Sasaki H, Campbell MS, Kraeft SK, Sutherland R, Yang CY, Liu Y, Auclair D, Hao L, Sonoda H, Ferland LH, Chen LB.

J Biol Chem. 1999 Dec 17;274(51):36544-9.


Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage.

Post S, Weng YC, Cimprich K, Chen LB, Xu Y, Lee EY.

Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13102-7. Epub 2001 Oct 30.


Downregulation of RAD17 in head and neck cancer.

Zhao M, Begum S, Ha PK, Westra W, Califano J.

Head Neck. 2008 Jan;30(1):35-42.


The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9.

Rauen M, Burtelow MA, Dufault VM, Karnitz LM.

J Biol Chem. 2000 Sep 22;275(38):29767-71.


The human homolog of fission yeast Rad17 is implicated in tumor growth.

Beretta GL, Gatti L, Cesare MD, Corna E, Tinelli S, Carenini N, Zunino F, Perego P.

Cancer Lett. 2008 Aug 8;266(2):194-202. doi: 10.1016/j.canlet.2008.02.057. Epub 2008 Apr 18.


3p21.3 tumor suppressor gene H37/Luca15/RBM5 inhibits growth of human lung cancer cells through cell cycle arrest and apoptosis.

Oh JJ, Razfar A, Delgado I, Reed RA, Malkina A, Boctor B, Slamon DJ.

Cancer Res. 2006 Apr 1;66(7):3419-27.


Overexpression of E2F1 associated with LOH at RB locus and hyperphosphorylation of RB in non-small cell lung carcinoma.

Imai MA, Oda Y, Oda M, Nakanishi I, Kawahara E.

J Cancer Res Clin Oncol. 2004 Jun;130(6):320-6. Epub 2004 Mar 3.


Down-regulation of Gadd45 expression is associated with tumor differentiation in non-small cell lung cancer.

Higashi H, Vallböhmer D, Warnecke-Eberz U, Hokita S, Xi H, Brabender J, Metzger R, Baldus SE, Natsugoe S, Aikou T, Hölscher AH, Schneider PM.

Anticancer Res. 2006 May-Jun;26(3A):2143-7.


Hrad17 expression in thymoma.

Sasaki H, Kobayashi Y, Yukiue H, Yano M, Kaji M, Fukai I, Kiriyama M, Yamakawa Y, Fujii Y.

Jpn J Thorac Cardiovasc Surg. 2003 Mar;51(3):81-5.


Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer.

Corn PG, Summers MK, Fogt F, Virmani AK, Gazdar AF, Halazonetis TD, El-Deiry WS.

Carcinogenesis. 2003 Jan;24(1):47-51.


HER-2/neu protein expression and gene alteration in stage I-IIIA non-small-cell lung cancer: a study of 140 cases using a combination of high throughput tissue microarray, immunohistochemistry, and fluorescent in situ hybridization.

Tan D, Deeb G, Wang J, Slocum HK, Winston J, Wiseman S, Beck A, Sait S, Anderson T, Nwogu C, Ramnath N, Loewen G.

Diagn Mol Pathol. 2003 Dec;12(4):201-11.


Frequent and histological type-specific inactivation of 14-3-3sigma in human lung cancers.

Osada H, Tatematsu Y, Yatabe Y, Nakagawa T, Konishi H, Harano T, Tezel E, Takada M, Takahashi T.

Oncogene. 2002 Apr 4;21(15):2418-24.


Accumulation of hRad9 protein in the nuclei of nonsmall cell lung carcinoma cells.

Maniwa Y, Yoshimura M, Bermudez VP, Yuki T, Okada K, Kanomata N, Ohbayashi C, Hayashi Y, Hurwitz J, Okita Y.

Cancer. 2005 Jan 1;103(1):126-32.


The fission yeast Rad32 (Mre11)-Rad50-Nbs1 complex is required for the S-phase DNA damage checkpoint.

Chahwan C, Nakamura TM, Sivakumar S, Russell P, Rhind N.

Mol Cell Biol. 2003 Sep;23(18):6564-73.

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