Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 101


Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis.

Lee MJ, Thangada S, Paik JH, Sapkota GP, Ancellin N, Chae SS, Wu M, Morales-Ruiz M, Sessa WC, Alessi DR, Hla T.

Mol Cell. 2001 Sep;8(3):693-704.


Sphingosine-1-phosphate, a platelet-derived lysophospholipid mediator, negatively regulates cellular Rac activity and cell migration in vascular smooth muscle cells.

Ryu Y, Takuwa N, Sugimoto N, Sakurada S, Usui S, Okamoto H, Matsui O, Takuwa Y.

Circ Res. 2002 Feb 22;90(3):325-32.


Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cells.

Morales-Ruiz M, Lee MJ, Zöllner S, Gratton JP, Scotland R, Shiojima I, Walsh K, Hla T, Sessa WC.

J Biol Chem. 2001 Jun 1;276(22):19672-7. Epub 2001 Mar 6.


Differential regulation of sphingosine-1-phosphate- and VEGF-induced endothelial cell chemotaxis. Involvement of G(ialpha2)-linked Rho kinase activity.

Liu F, Verin AD, Wang P, Day R, Wersto RP, Chrest FJ, English DK, Garcia JG.

Am J Respir Cell Mol Biol. 2001 Jun;24(6):711-9.


Sphingosine-1-phosphate signaling in endothelial activation.

Ozaki H, Hla T, Lee MJ.

J Atheroscler Thromb. 2003;10(3):125-31. Review.


EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration.

Rosenfeldt HM, Hobson JP, Maceyka M, Olivera A, Nava VE, Milstien S, Spiegel S.

FASEB J. 2001 Dec;15(14):2649-59.


The sphingosine-1-phosphate receptor EDG-1 is essential for platelet-derived growth factor-induced cell motility.

Rosenfeldt HM, Hobson JP, Milstien S, Spiegel S.

Biochem Soc Trans. 2001 Nov;29(Pt 6):836-9.


Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3.

Okamoto H, Takuwa N, Yokomizo T, Sugimoto N, Sakurada S, Shigematsu H, Takuwa Y.

Mol Cell Biol. 2000 Dec;20(24):9247-61.


Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis.

Wang F, Van Brocklyn JR, Hobson JP, Movafagh S, Zukowska-Grojec Z, Milstien S, Spiegel S.

J Biol Chem. 1999 Dec 10;274(50):35343-50.


Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors.

Malek RL, Toman RE, Edsall LC, Wong S, Chiu J, Letterle CA, Van Brocklyn JR, Milstien S, Spiegel S, Lee NH.

J Biol Chem. 2001 Feb 23;276(8):5692-9. Epub 2000 Nov 7.


Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors.

Hla T, Lee MJ, Ancellin N, Thangada S, Liu CH, Kluk M, Chae SS, Wu MT.

Ann N Y Acad Sci. 2000 Apr;905:16-24. Review.


Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing.

Lee H, Goetzl EJ, An S.

Am J Physiol Cell Physiol. 2000 Mar;278(3):C612-8.

Supplemental Content

Support Center