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Items: 1 to 20 of 132


Role of thrombin signalling in platelets in haemostasis and thrombosis.

Sambrano GR, Weiss EJ, Zheng YW, Huang W, Coughlin SR.

Nature. 2001 Sep 6;413(6851):74-8.


PAR3 is a cofactor for PAR4 activation by thrombin.

Nakanishi-Matsui M, Zheng YW, Sulciner DJ, Weiss EJ, Ludeman MJ, Coughlin SR.

Nature. 2000 Apr 6;404(6778):609-13.


A dual thrombin receptor system for platelet activation.

Kahn ML, Zheng YW, Huang W, Bigornia V, Zeng D, Moff S, Farese RV Jr, Tam C, Coughlin SR.

Nature. 1998 Aug 13;394(6694):690-4.


Roles and interactions among protease-activated receptors and P2ry12 in hemostasis and thrombosis.

Cornelissen I, Palmer D, David T, Wilsbacher L, Concengco C, Conley P, Pandey A, Coughlin SR.

Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18605-10. doi: 10.1073/pnas.1013309107. Epub 2010 Oct 7.


Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIbα.

Carrim N, Arthur JF, Hamilton JR, Gardiner EE, Andrews RK, Moran N, Berndt MC, Metharom P.

Redox Biol. 2015 Dec;6:640-7. doi: 10.1016/j.redox.2015.10.009. Epub 2015 Oct 28.


Protection against thrombosis in mice lacking PAR3.

Weiss EJ, Hamilton JR, Lease KE, Coughlin SR.

Blood. 2002 Nov 1;100(9):3240-4.


Glycoprotein Ib-mediated platelet activation. A signalling pathway triggered by thrombin.

Adam F, Guillin MC, Jandrot-Perrus M.

Eur J Biochem. 2003 Jul;270(14):2959-70.


Redundancy and interaction of thrombin- and collagen-mediated platelet activation in tail bleeding and carotid thrombosis in mice.

Bynagari-Settipalli YS, Cornelissen I, Palmer D, Duong D, Concengco C, Ware J, Coughlin SR.

Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2563-9. doi: 10.1161/ATVBAHA.114.304244. Epub 2014 Oct 2.


Thrombin-induced platelet activation via PAR4: pivotal role for exosite II.

Boknäs N, Faxälv L, Sanchez Centellas D, Wallstedt M, Ramström S, Grenegård M, Lindahl TL.

Thromb Haemost. 2014 Sep 2;112(3):558-65. doi: 10.1160/TH13-12-1013. Epub 2014 Jul 3.


The contribution of thrombin-induced platelet activation to thrombus growth is diminished under pathological blood shear conditions.

Lee H, Sturgeon SA, Jackson SP, Hamilton JR.

Thromb Haemost. 2012 Feb;107(2):328-37. doi: 10.1160/TH11-06-0418. Epub 2011 Dec 21.


Unique pathway of thrombin-induced platelet aggregation mediated by glycoprotein Ib.

Soslau G, Class R, Morgan DA, Foster C, Lord ST, Marchese P, Ruggeri ZM.

J Biol Chem. 2001 Jun 15;276(24):21173-83. Epub 2001 Mar 30.


Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin.

Kahn ML, Nakanishi-Matsui M, Shapiro MJ, Ishihara H, Coughlin SR.

J Clin Invest. 1999 Mar;103(6):879-87.


Signaling-mediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation.

Estevez B, Kim K, Delaney MK, Stojanovic-Terpo A, Shen B, Ruan C, Cho J, Ruggeri ZM, Du X.

Blood. 2016 Feb 4;127(5):626-36. doi: 10.1182/blood-2015-04-638387. Epub 2015 Nov 19.


Calcium mobilization and protein kinase C activation downstream of protease activated receptor 4 (PAR4) is negatively regulated by PAR3 in mouse platelets.

Arachiche A, de la Fuente M, Nieman MT.

PLoS One. 2013;8(2):e55740. doi: 10.1371/journal.pone.0055740. Epub 2013 Feb 6. Erratum in: PLoS One. 2013;8(12). doi:10.1371/annotation/0956857d-ecf5-4fb7-a834-131915a38a6a.


Par4 is required for platelet thrombus propagation but not fibrin generation in a mouse model of thrombosis.

Vandendries ER, Hamilton JR, Coughlin SR, Furie B, Furie BC.

Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):288-92. Epub 2006 Dec 26.


Trypsin causes platelet activation independently of known protease-activated receptors.

Mao Y, Kunapuli SP.

Thromb Haemost. 2013 Dec;110(6):1241-9. doi: 10.1160/TH13-03-0189. Epub 2013 Sep 12.


Contribution of protease-activated receptors 1 and 4 and glycoprotein Ib-IX-V in the G(i)-independent activation of platelet Rap1B by thrombin.

Lova P, Campus F, Lombardi R, Cattaneo M, Sinigaglia F, Balduini C, Torti M.

J Biol Chem. 2004 Jun 11;279(24):25299-306. Epub 2004 Apr 12.


Blocking the protease-activated receptor 1-4 heterodimer in platelet-mediated thrombosis.

Leger AJ, Jacques SL, Badar J, Kaneider NC, Derian CK, Andrade-Gordon P, Covic L, Kuliopulos A.

Circulation. 2006 Mar 7;113(9):1244-54. Epub 2006 Feb 27.

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