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11518847,12859420,8390524,10720593,9821855,15076168,10968199,2246027,8181146,10423611,8719794,17460373,9310205,20625318,19047581,20702114,32418498,8583785,9127812,8613236,15882554,9453261,11086633,10076925,9321741,1533747,11208762,11939622,8564253,10559680,9740624,10994756,7500546,11274226,9892151,15717137,8228190,20118410,8505110,2522478,9832289,15496307,8569216,12653675,8879346,9533614,8133017,12011652,16839316,12588634,9797193,12658029,7836732,11330882,7889211,7615951,15522279,19948989,31023080,9493120,17143193,18047624,9321751,10805052,11260386,15126924,12542457,10779052,7965270,9493122,34879704,1343288,15710752,10608466,14573331,10777033,10750588,11903302,1387008,8800599,10578002,10981551,9260993,8201847,11040238,18753741,9268224,15833808,10826401,9403569,16156511,9331000,9493125,7594427,10876800,2194942,16269964,15479174,22158111,1435062,12923401,10076918,9655651,10697305,10076920,24292382,10076923,10474777,3030586,10779124,12010090,10404959,15615839,10872560,8986455,11875311,16331113,11332334,15016632,12154518,11677370,9663925,9218180,1387843,27085127,9211168,9493123,10720105,17064684,11677376,24647710,11081784,12661917,11325076,11924731,10419064,9315367,12777947,10489114,9409311,9072422,10806829,11325077,12376396,9293963,20128808,11086231,20411619,10323771,9786599,9869009,10076915,8039265,18788121,8527352,7613528,21326110,18158350,9247747,16148610,11251645,10854085,18344629,8467569,12775556,11821713,8542682,10412883,9383173,15662233,31096810,9926278,9833158,10076917,15097243,8951556,15749748,7700888,9247768,12361194,8986928,8039264,12930272,19531557,9557932,8800589,12675282,33930369,9321748,12973413,19917062,10513838,9171960,1959233,25016364,24397813,8717062,9764721,8582109,15080380,15308481,31739443,20126350,10235635,20966610,2936329,10369385,12207569,15662231,22195025,10703891,11449994,9582107,7584913,9072332,11031218,17283869,15187493,14761073,24924395,29605766,9431852,15662228,11368889,23736127,23539907,11316067,20679181,9072428,8306513,9218184,19202318,12923407,29229547,20001455,11910311,25626873,12409969,22957022,12923410,10515445,18800451,11380518,20589978,10744354,11327634,9746122,9171955,11903318,2821208,7923892,11416677,14620930,9833166,10081615,35862154,1659958,15834293,12023685,28640888,8539265,12123630,12131533,12924625,1395115,2562138,11116050,8902551,15076191,18800450,20543085,30499710,3699625,17318787,9181252,33479758,17906684,11213032,11016803,11593110,15662220,10466478,9486085,10764658,1764812,2876791,26811052,11707239,17641443,3899419,36855263,31361702,31348596,12929469,18597587,8685076,9235795,8934361,18703536,33394824,9950833,16331114,8801264,9072429,11903508,17630351,7494560,36849061,1720358,32522899,9793780,1454748,33841179,11330881,7557736,1327597,23876211,14714578,11883791,32688435,14686964,7827369,24072555,22500216,33573539,31132670,11716799,25122644,22710644,12452331,10516871,16914423,6086183,34743271,2821207,15894900,8596776,1395112,19466524,1964405,21937997,1424216,9072367,30755073,14567503,34259014,18637711,30537058,12431442,11212064,1282386,11924717,23045456,33687310,12135327,1829659,3024889,36930883,20837116,10326661,24927350,21697522,7632518,15000295,10912779,9257117,15257859,9072431,19942928,17566078,16845252,30102356,31030610,9170005,12231564,14574083,2001473,9833177,17557916,30540685,8582104,31746626,22918977,30622171,12671327,15271667,2836872,30977084,9797177,12544451,3552864,11085284,7496564,3171884,24685050,8076427,20724490,31356181,31059021,20870672,2150362,1998761,2530011,28364692,23469072,18369742,11451212,1345051,8986915,11196069,12135326,20507873,14649307,20679182,32485572,9689152,32195823,10102968,24020816,3841035,7768485,31468385,34757002,6099783,10076922,11595564,8800600,10076921,15361770,10728359,15155278,9926001,8781750,32790534,21818547,21287150,12131539,12803570,15840410,8173699,14508195,11403357,1674420,8891746,33611212,9540129,31063551,12542453,11339689,29142252,35171185,9225731,22895019,20493549,10981096,33904655,29232407,34944506,8781749,16707327,22552605,1345222,9663919,15665062,9797175,7621613,10419059,2975341,9119799,26010093,33390039,9607405,2977152,2178480,12089043,31409604,35916128,11206703,10580398,32162100,2852722,22215705,19644507,11207677,11288821,9677617,10669640,23369979,31170664,2791319,30681344,7215068,34739764,15997171,6339120,11593103,20359465,19339677,12450247,12011662,22180357,15894893,16636899,7505033,9385473,19491530,24958497,17442227,8395169,36058640,1379487,2947562,9886895,8193608,10451035,20136844,9758089,22114203,8573751,2986154,22930266,29244531,7982275,1827989,20937029,1535655,11710757,1829664,9538933,20029960,8729434,10076924,10384255,19828927,18609298,12479242,2050283,28695320,34074111,11856772,9648942,11337009,2653950,10574415,19614803,30472496,12933361,3991983,17952638,33870805,8842564,7959414,29750475,12135325,2861268,12680847,30624528,22001985,17351382,24175973,15302988,36364864,33486989,1608038,30209283,19531637,21373977,26640237,32317965,23661144,6684005,20562518,27951594,31724456,14508204,32504676,31474709,1944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Page 1

Persistent cardiovascular effects of chronic renin-angiotensin system inhibition following withdrawal in adult spontaneously hypertensive rats.

Paull JR, Widdop RE. Paull JR, et al. J Hypertens. 2001 Aug;19(8):1393-402. doi: 10.1097/00004872-200108000-00007. J Hypertens. 2001. PMID: 11518847

Cardiovascular status following combined angiotensin-converting enzyme and AT1 receptor inhibition in conscious spontaneously hypertensive rats.

Duke LM, Paull JR, Widdop RE. Duke LM, et al. Clin Exp Pharmacol Physiol. 2003 May-Jun;30(5-6):317-23. doi: 10.1046/j.1440-1681.2003.03837.x. Clin Exp Pharmacol Physiol. 2003. PMID: 12859420

Relationship between cardiovascular hypertrophy and cardiac baroreflex function in spontaneously hypertensive and stroke-prone rats.

Minami N, Head GA. Minami N, et al. J Hypertens. 1993 May;11(5):523-33. doi: 10.1097/00004872-199305000-00008. J Hypertens. 1993. PMID: 8390524

Cardiovascular effects of combination of perindopril, candesartan, and amlodipine in hypertensive rats.

Kim S, Zhan Y, Izumi Y, Iwao H. Kim S, et al. Hypertension. 2000 Mar;35(3):769-74. doi: 10.1161/01.hyp.35.3.769. Hypertension. 2000. PMID: 10720593

Effects of candesartan cilexetil and enalapril on structural alterations and endothelial function in small resistance arteries of spontaneously hypertensive rats.

Rizzoni D, Porteri E, Bettoni G, Piccoli A, Castellano M, Muiesan ML, Pasini G, Guelfi D, Rosei EA. Rizzoni D, et al. J Cardiovasc Pharmacol. 1998 Nov;32(5):798-806. doi: 10.1097/00005344-199811000-00017. J Cardiovasc Pharmacol. 1998. PMID: 9821855

Combined blockade of AT1-receptors and ACE synergistically potentiates antihypertensive effects in SHR.

Raasch W, Jöhren O, Schwartz S, Gieselberg A, Dominiak P. Raasch W, et al. J Hypertens. 2004 Mar;22(3):611-8. doi: 10.1097/00004872-200403000-00025. J Hypertens. 2004. PMID: 15076168

Comparison of the antihypertensive effects of the new angiotensin II (AT1) receptor antagonist candesartan cilexetil (TCV-116) and the angiotensin converting enzyme inhibitor enalapril in rats.

Wada T, Inada Y, Ojima M, Sanada T, Shibouta Y, Nishikawa K. Wada T, et al. Hypertens Res. 1996 Jun;19(2):75-81. doi: 10.1291/hypres.19.75. Hypertens Res. 1996. PMID: 10968199 Free article.

Brief angiotensin converting enzyme inhibitor treatment in young spontaneously hypertensive rats reduces blood pressure long-term.

Harrap SB, Van der Merwe WM, Griffin SA, Macpherson F, Lever AF. Harrap SB, et al. Hypertension. 1990 Dec;16(6):603-14. doi: 10.1161/01.hyp.16.6.603. Hypertension. 1990. PMID: 2246027

Angiotensin II receptor antagonist TCV-116 induces regression of hypertensive left ventricular hypertrophy in vivo and inhibits the intracellular signaling pathway of stretch-mediated cardiomyocyte hypertrophy in vitro.

Kojima M, Shiojima I, Yamazaki T, Komuro I, Zou Z, Wang Y, Mizuno T, Ueki K, Tobe K, Kadowaki T, et al. Kojima M, et al. Circulation. 1994 May;89(5):2204-11. doi: 10.1161/01.cir.89.5.2204. Circulation. 1994. PMID: 8181146

Comparative effects of three sites of renin-angiotensin blockade on the regression of left ventricular hypertrophy in spontaneously hypertensive rats.

Zhang Q, Kohara K, Qui HY, Hiwada K. Zhang Q, et al. Am J Ther. 1997 May-Jun;4(5-6):199-202. doi: 10.1097/00045391-199705000-00006. Am J Ther. 1997. PMID: 10423611

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