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ERK regulates the hepatocyte growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase.

Yu CF, Roshan B, Liu ZX, Cantley LG.

J Biol Chem. 2001 Aug 31;276(35):32552-8. Epub 2001 Jul 9.


ERK negatively regulates the epidermal growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase.

Yu CF, Liu ZX, Cantley LG.

J Biol Chem. 2002 May 31;277(22):19382-8. Epub 2002 Mar 14.


Hepatocyte growth factor induces ERK-dependent paxillin phosphorylation and regulates paxillin-focal adhesion kinase association.

Liu ZX, Yu CF, Nickel C, Thomas S, Cantley LG.

J Biol Chem. 2002 Mar 22;277(12):10452-8. Epub 2002 Jan 9.


Src phosphorylates Grb2-associated binder 1 upon hepatocyte growth factor stimulation.

Chan PC, Chen YL, Cheng CH, Yu KC, Cary LA, Shu KH, Ho WL, Chen HC.

J Biol Chem. 2003 Nov 7;278(45):44075-82. Epub 2003 Aug 25.


Solution structure of the C-terminal SH2 domain of the p85 alpha regulatory subunit of phosphoinositide 3-kinase.

Siegal G, Davis B, Kristensen SM, Sankar A, Linacre J, Stein RC, Panayotou G, Waterfield MD, Driscoll PC.

J Mol Biol. 1998 Feb 20;276(2):461-78.


Identification of major ERK-related phosphorylation sites in Gab1.

Lehr S, Kotzka J, Avci H, Sickmann A, Meyer HE, Herkner A, Muller-Wieland D.

Biochemistry. 2004 Sep 28;43(38):12133-40.


SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange.

Felder S, Zhou M, Hu P, UreƱa J, Ullrich A, Chaudhuri M, White M, Shoelson SE, Schlessinger J.

Mol Cell Biol. 1993 Mar;13(3):1449-55.


Unique phosphorylation mechanism of Gab1 using PI 3-kinase as an adaptor protein.

Onishi-Haraikawa Y, Funaki M, Gotoh N, Shibuya M, Inukai K, Katagiri H, Fukushima Y, Anai M, Ogihara T, Sakoda H, Ono H, Kikuchi M, Oka Y, Asano T.

Biochem Biophys Res Commun. 2001 Oct 26;288(2):476-82.


A function for phosphoinositide 3-kinase beta lipid products in coupling beta gamma to Ras activation in response to lysophosphatidic acid.

Yart A, Roche S, Wetzker R, Laffargue M, Tonks N, Mayeux P, Chap H, Raynal P.

J Biol Chem. 2002 Jun 14;277(24):21167-78. Epub 2002 Mar 26.


Activation of gp130 transduces hypertrophic signal through interaction of scaffolding/docking protein Gab1 with tyrosine phosphatase SHP2 in cardiomyocytes.

Nakaoka Y, Nishida K, Fujio Y, Izumi M, Terai K, Oshima Y, Sugiyama S, Matsuda S, Koyasu S, Yamauchi-Takihara K, Hirano T, Kawase I, Hirota H.

Circ Res. 2003 Aug 8;93(3):221-9. Epub 2003 Jul 10.


Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL.

Sakkab D, Lewitzky M, Posern G, Schaeper U, Sachs M, Birchmeier W, Feller SM.

J Biol Chem. 2000 Apr 14;275(15):10772-8.


Inhibition of phosphatidylinositol 3-kinase- and ERK MAPK-regulated protein synthesis reveals the pro-apoptotic properties of CD40 ligation in carcinoma cells.

Davies CC, Mason J, Wakelam MJ, Young LS, Eliopoulos AG.

J Biol Chem. 2004 Jan 9;279(2):1010-9. Epub 2003 Oct 27.


A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation.

Montagner A, Yart A, Dance M, Perret B, Salles JP, Raynal P.

J Biol Chem. 2005 Feb 18;280(7):5350-60. Epub 2004 Dec 1.


Hepatocyte growth factor/scatter factor activates the ETS1 transcription factor by a RAS-RAF-MEK-ERK signaling pathway.

Paumelle R, Tulasne D, Kherrouche Z, Plaza S, Leroy C, Reveneau S, Vandenbunder B, Fafeur V.

Oncogene. 2002 Apr 4;21(15):2309-19. Erratum in: Oncogene 2002 Jul 18;21(31):4872. Tulashe, David [corrected to Tulasne, David]; Reveneau, Syline [corrected to Reveneau, Sylvie].


Hepatocyte growth factor induces proliferation of lens epithelial cells through activation of ERK1/2 and JNK/SAPK.

Choi J, Park SY, Joo CK.

Invest Ophthalmol Vis Sci. 2004 Aug;45(8):2696-704.


Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor beta-receptor sequences: analysis of kinetic parameters by a novel biosensor-based approach.

Panayotou G, Gish G, End P, Truong O, Gout I, Dhand R, Fry MJ, Hiles I, Pawson T, Waterfield MD.

Mol Cell Biol. 1993 Jun;13(6):3567-76.


Interaction of the insulin receptor beta-subunit with phosphatidylinositol 3-kinase in bovine ROS.

Rajala RV, Anderson RE.

Invest Ophthalmol Vis Sci. 2001 Dec;42(13):3110-7.


Two phosphorylation-independent sites on the p85 SH2 domains bind A-Raf kinase.

Fang Y, Johnson LM, Mahon ES, Anderson DH.

Biochem Biophys Res Commun. 2002 Feb 1;290(4):1267-74.


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