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Items: 1 to 20 of 245

1.

Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3.

Barber AJ, Nakamura M, Wolpert EB, Reiter CE, Seigel GM, Antonetti DA, Gardner TW.

J Biol Chem. 2001 Aug 31;276(35):32814-21. Epub 2001 Jul 6.

3.

PDGF- and insulin/IGF-1-specific distinct modes of class IA PI 3-kinase activation in normal rat retinas and RGC-5 retinal ganglion cells.

Biswas SK, Zhao Y, Nagalingam A, Gardner TW, Sandirasegarane L.

Invest Ophthalmol Vis Sci. 2008 Aug;49(8):3687-98. doi: 10.1167/iovs.07-1455. Epub 2008 Apr 17.

PMID:
18421086
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5.

Phosphatidylinositol 3-kinase-mediated regulation of neuronal apoptosis and necrosis by insulin and IGF-I.

Ryu BR, Ko HW, Jou I, Noh JS, Gwag BJ.

J Neurobiol. 1999 Jun 15;39(4):536-46.

PMID:
10380075
7.

Insulin-like growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and phosphatidylinositol 3'-kinase-Akt signaling pathways.

Thimmaiah KN, Easton J, Huang S, Veverka KA, Germain GS, Harwood FC, Houghton PJ.

Cancer Res. 2003 Jan 15;63(2):364-74.

8.

Midkine inhibits caspase-dependent apoptosis via the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase in cultured neurons.

Owada K, Sanjo N, Kobayashi T, Mizusawa H, Muramatsu H, Muramatsu T, Michikawa M.

J Neurochem. 1999 Nov;73(5):2084-92.

9.

Role of PI 3-kinase, Akt and Bcl-2-related proteins in sustaining the survival of neurotrophic factor-independent adult sympathetic neurons.

Orike N, Middleton G, Borthwick E, Buchman V, Cowen T, Davies AM.

J Cell Biol. 2001 Sep 3;154(5):995-1005. Epub 2001 Aug 27.

10.

Nerve growth factor-induced PKB/Akt activity is sustained by phosphoinositide 3-kinase dependent and independent signals in sympathetic neurons.

Virdee K, Xue L, Hemmings BA, Goemans C, Heumann R, Tolkovsky AM.

Brain Res. 1999 Aug 7;837(1-2):127-42.

PMID:
10433995
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Insulin-like growth factor-I is a potential trophic factor for amacrine cells.

Politi LE, Rotstein NP, Salvador G, Giusto NM, Insua MF.

J Neurochem. 2001 Feb;76(4):1199-211.

17.

Phosphoinositide 3-hydroxide kinase blockade enhances apoptosis in the Ewing's sarcoma family of tumors.

Toretsky JA, Thakar M, Eskenazi AE, Frantz CN.

Cancer Res. 1999 Nov 15;59(22):5745-50.

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Regulation of neuronal survival by the serine-threonine protein kinase Akt.

Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR, Greenberg ME.

Science. 1997 Jan 31;275(5300):661-5.

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