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The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor zeta chain.

Purbhoo MA, Boulter JM, Price DA, Vuidepot AL, Hourigan CS, Dunbar PR, Olson K, Dawson SJ, Phillips RE, Jakobsen BK, Bell JI, Sewell AK.

J Biol Chem. 2001 Aug 31;276(35):32786-92. Epub 2001 Jul 3.


A binding site for the T-cell co-receptor CD8 on the alpha 3 domain of HLA-A2.

Salter RD, Benjamin RJ, Wesley PK, Buxton SE, Garrett TP, Clayberger C, Krensky AM, Norment AM, Littman DR, Parham P.

Nature. 1990 May 3;345(6270):41-6.


Role of conserved regions of class I MHC molecules in the activation of CD8+ cytotoxic T lymphocytes by peptide and purified cell-free class I molecules.

Takeshita T, Kozlowski S, England RD, Brower R, Schneck J, Takahashi H, DeLisi C, Margulies DH, Berzofsky JA.

Int Immunol. 1993 Sep;5(9):1129-38.


A novel approach to antigen-specific deletion of CTL with minimal cellular activation using alpha3 domain mutants of MHC class I/peptide complex.

Xu XN, Purbhoo MA, Chen N, Mongkolsapaya J, Cox JH, Meier UC, Tafuro S, Dunbar PR, Sewell AK, Hourigan CS, Appay V, Cerundolo V, Burrows SR, McMichael AJ, Screaton GR.

Immunity. 2001 May;14(5):591-602.


CD8 T cells, like CD4 T cells, are triggered by multivalent engagement of TCRs by MHC-peptide ligands but not by monovalent engagement.

Stone JD, Stern LJ.

J Immunol. 2006 Feb 1;176(3):1498-505. Erratum in: J Immunol. 2006 Mar 15;176(6):3843.


Impact of CD8-MHC class I interaction in detection and sorting efficiencies of antigen-specific T cells using MHC class I/peptide multimers: contribution of pMHC valency.

Neveu B, Echasserieau K, Hill T, Kuus-Reichel K, Houssaint E, Bonneville M, Saulquin X.

Int Immunol. 2006 Jul;18(7):1139-45. Epub 2006 Jun 2.


Novel CD8+ T cell antagonists based on beta 2-microglobulin.

Glick M, Price DA, Vuidepot AL, Andersen TB, Hutchinson SL, Laugel B, Sewell AK, Boulter JM, Dunbar PR, Cerundolo V, Oxenius A, Bell JI, Richards WG, Jakobsen BK.

J Biol Chem. 2002 Jun 7;277(23):20840-6. Epub 2002 Mar 25.


The CD8 T cell coreceptor exhibits disproportionate biological activity at extremely low binding affinities.

Hutchinson SL, Wooldridge L, Tafuro S, Laugel B, Glick M, Boulter JM, Jakobsen BK, Price DA, Sewell AK.

J Biol Chem. 2003 Jul 4;278(27):24285-93. Epub 2003 Apr 15.


The duration of TCR/pMHC interactions regulates CTL effector function and tumor-killing capacity.

Riquelme E, Carreño LJ, González PA, Kalergis AM.

Eur J Immunol. 2009 Aug;39(8):2259-69. doi: 10.1002/eji.200939341.


Impact of antigen presentation on TCR modulation and cytokine release: implications for detection and sorting of antigen-specific CD8+ T cells using HLA-A2 wild-type or HLA-A2 mutant tetrameric complexes.

Jäger E, Salter R, Castelli C, Höhn H, Freitag K, Karbach J, Neukirch C, Necker A, Knuth A, Maeurer MJ.

J Immunol. 2002 Mar 15;168(6):2766-72.


Low binding capacity of murine tetramers mutated at residue 227 does not preclude the ability to efficiently activate CD8+ T lymphocytes.

Nugent CT, Renteria RO, Kuus-Reichel K, Kumar A.

Immunol Lett. 2005 May 15;98(2):208-15. Epub 2004 Dec 10.


Selecting T cell receptors with high affinity for self-MHC by decreasing the contribution of CD8.

Sherman LA, Hesse SV, Irwin MJ, La Face D, Peterson P.

Science. 1992 Oct 30;258(5083):815-8.


Discrepancy between ELISPOT IFN-gamma secretion and binding of A2/peptide multimers to TCR reveals interclonal dissociation of CTL effector function from TCR-peptide/MHC complexes half-life.

Rubio-Godoy V, Dutoit V, Rimoldi D, Lienard D, Lejeune F, Speiser D, Guillaume P, Cerottini JC, Romero P, Valmori D.

Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10302-7. Epub 2001 Aug 21.


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