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Items: 1 to 20 of 286

1.

Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343.

Persad S, Attwell S, Gray V, Mawji N, Deng JT, Leung D, Yan J, Sanghera J, Walsh MP, Dedhar S.

J Biol Chem. 2001 Jul 20;276(29):27462-9. Epub 2001 Apr 19.

2.

Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation.

Troussard AA, Mawji NM, Ong C, Mui A, St -Arnaud R, Dedhar S.

J Biol Chem. 2003 Jun 20;278(25):22374-8. Epub 2003 Apr 8.

3.

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase.

Delcommenne M, Tan C, Gray V, Rue L, Woodgett J, Dedhar S.

Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11211-6.

4.

Preferential dependence of breast cancer cells versus normal cells on integrin-linked kinase for protein kinase B/Akt activation and cell survival.

Troussard AA, McDonald PC, Wederell ED, Mawji NM, Filipenko NR, Gelmon KA, Kucab JE, Dunn SE, Emerman JT, Bally MB, Dedhar S.

Cancer Res. 2006 Jan 1;66(1):393-403.

5.

Integrin-linked kinase (ILK): a "hot" therapeutic target.

Yoganathan TN, Costello P, Chen X, Jabali M, Yan J, Leung D, Zhang Z, Yee A, Dedhar S, Sanghera J.

Biochem Pharmacol. 2000 Oct 15;60(8):1115-9. Review.

PMID:
11007949
6.
7.

Caenorhabditis elegans PIAK, a phospholipid-independent kinase that activates the AKT/PKB survival kinase.

Li Y, Dowbenko D, Lasky LA.

J Biol Chem. 2001 Jun 8;276(23):20323-9. Epub 2001 Mar 23.

8.
9.

Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma.

Koul D, Shen R, Bergh S, Lu Y, de Groot JF, Liu TJ, Mills GB, Yung WK.

Mol Cancer Ther. 2005 Nov;4(11):1681-8.

10.

AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival.

Li Y, Dowbenko D, Lasky LA.

J Biol Chem. 2002 Mar 29;277(13):11352-61. Epub 2001 Dec 27.

11.
12.

Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival.

McDonald PC, Oloumi A, Mills J, Dobreva I, Maidan M, Gray V, Wederell ED, Bally MB, Foster LJ, Dedhar S.

Cancer Res. 2008 Mar 15;68(6):1618-24. doi: 10.1158/0008-5472.CAN-07-5869.

13.

The integrin-linked kinase (ILK) suppresses anoikis.

Attwell S, Roskelley C, Dedhar S.

Oncogene. 2000 Aug 3;19(33):3811-5.

14.

Identification of major ERK-related phosphorylation sites in Gab1.

Lehr S, Kotzka J, Avci H, Sickmann A, Meyer HE, Herkner A, Muller-Wieland D.

Biochemistry. 2004 Sep 28;43(38):12133-40.

PMID:
15379552
15.

Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI.

Barry FA, Gibbins JM.

J Biol Chem. 2002 Apr 12;277(15):12874-8. Epub 2002 Feb 1.

16.

The role of integrin-linked kinase (ILK) in cancer progression.

Persad S, Dedhar S.

Cancer Metastasis Rev. 2003 Dec;22(4):375-84. Review.

PMID:
12884912
17.
18.

Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells.

Persad S, Attwell S, Gray V, Delcommenne M, Troussard A, Sanghera J, Dedhar S.

Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3207-12.

19.

A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis.

Anai M, Shojima N, Katagiri H, Ogihara T, Sakoda H, Onishi Y, Ono H, Fujishiro M, Fukushima Y, Horike N, Viana A, Kikuchi M, Noguchi N, Takahashi S, Takata K, Oka Y, Uchijima Y, Kurihara H, Asano T.

J Biol Chem. 2005 May 6;280(18):18525-35. Epub 2005 Mar 7.

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