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Items: 1 to 20 of 77

1.

Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin.

Geick A, Eichelbaum M, Burk O.

J Biol Chem. 2001 May 4;276(18):14581-7. Epub 2001 Jan 31.

2.

A role for constitutive androstane receptor in the regulation of human intestinal MDR1 expression.

Burk O, Arnold KA, Geick A, Tegude H, Eichelbaum M.

Biol Chem. 2005 Jun;386(6):503-13.

PMID:
16006237
3.

Thyroid hormone receptor mediates human MDR1 gene expression-Identification of the response region essential for gene expression.

Kurose K, Saeki M, Tohkin M, Hasegawa R.

Arch Biochem Biophys. 2008 Jun 1;474(1):82-90. doi: 10.1016/j.abb.2008.03.020. Epub 2008 Mar 25.

PMID:
18395509
6.

The induction of cytochrome P450 3A5 (CYP3A5) in the human liver and intestine is mediated by the xenobiotic sensors pregnane X receptor (PXR) and constitutively activated receptor (CAR).

Burk O, Koch I, Raucy J, Hustert E, Eichelbaum M, Brockmöller J, Zanger UM, Wojnowski L.

J Biol Chem. 2004 Sep 10;279(37):38379-85. Epub 2004 Jul 12.

7.

MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype.

Lamba J, Strom S, Venkataramanan R, Thummel KE, Lin YS, Liu W, Cheng C, Lamba V, Watkins PB, Schuetz E.

Clin Pharmacol Ther. 2006 Apr;79(4):325-38. Epub 2006 Feb 20.

PMID:
16580901
8.
9.

In vivo activation of the human CYP3A4 promoter in mouse liver and regulation by pregnane X receptors.

Zhang W, Purchio A, Chen K, Burns SM, Contag CH, Contag PR.

Biochem Pharmacol. 2003 Jun 1;65(11):1889-96.

PMID:
12781341
10.
11.

Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor.

Burk O, Arnold KA, Nussler AK, Schaeffeler E, Efimova E, Avery BA, Avery MA, Fromm MF, Eichelbaum M.

Mol Pharmacol. 2005 Jun;67(6):1954-65. Epub 2005 Mar 10.

12.

Role of Sp1, C/EBP alpha, HNF3, and PXR in the basal- and xenobiotic-mediated regulation of the CYP3A4 gene.

Bombail V, Taylor K, Gibson GG, Plant N.

Drug Metab Dispos. 2004 May;32(5):525-35.

13.

Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3.

Thummel KE, Brimer C, Yasuda K, Thottassery J, Senn T, Lin Y, Ishizuka H, Kharasch E, Schuetz J, Schuetz E.

Mol Pharmacol. 2001 Dec;60(6):1399-406.

14.

The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4.

Tirona RG, Lee W, Leake BF, Lan LB, Cline CB, Lamba V, Parviz F, Duncan SA, Inoue Y, Gonzalez FJ, Schuetz EG, Kim RB.

Nat Med. 2003 Feb;9(2):220-4. Epub 2003 Jan 6.

PMID:
12514743
15.

Induction of phase I, II and III drug metabolism/transport by xenobiotics.

Xu C, Li CY, Kong AN.

Arch Pharm Res. 2005 Mar;28(3):249-68. Review.

PMID:
15832810
16.
17.

Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics.

Smirlis D, Muangmoonchai R, Edwards M, Phillips IR, Shephard EA.

J Biol Chem. 2001 Apr 20;276(16):12822-6. Epub 2001 Jan 24.

18.
19.

Regulation of CYP3A4 by pregnane X receptor: The role of nuclear receptors competing for response element binding.

Istrate MA, Nussler AK, Eichelbaum M, Burk O.

Biochem Biophys Res Commun. 2010 Mar 19;393(4):688-93. doi: 10.1016/j.bbrc.2010.02.058. Epub 2010 Feb 18.

PMID:
20171174
20.

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