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TIF-IA, the factor mediating growth-dependent control of ribosomal RNA synthesis, is the mammalian homolog of yeast Rrn3p.

Bodem J, Dobreva G, Hoffmann-Rohrer U, Iben S, Zentgraf H, Delius H, Vingron M, Grummt I.

EMBO Rep. 2000 Aug;1(2):171-5.


Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter.

Yuan X, Zhao J, Zentgraf H, Hoffmann-Rohrer U, Grummt I.

EMBO Rep. 2002 Nov;3(11):1082-7. Epub 2002 Oct 22.


TOR-dependent reduction in the expression level of Rrn3p lowers the activity of the yeast RNA Pol I machinery, but does not account for the strong inhibition of rRNA production.

Philippi A, Steinbauer R, Reiter A, Fath S, Leger-Silvestre I, Milkereit P, Griesenbeck J, Tschochner H.

Nucleic Acids Res. 2010 Sep;38(16):5315-26. doi: 10.1093/nar/gkq264. Epub 2010 Apr 25.


Phosphorylation by casein kinase 2 facilitates rRNA gene transcription by promoting dissociation of TIF-IA from elongating RNA polymerase I.

Bierhoff H, Dundr M, Michels AA, Grummt I.

Mol Cell Biol. 2008 Aug;28(16):4988-98. doi: 10.1128/MCB.00492-08. Epub 2008 Jun 16.


Activation of an endogenous suicide response after perturbation of rRNA synthesis leads to neurodegeneration in mice.

Parlato R, Kreiner G, Erdmann G, Rieker C, Stotz S, Savenkova E, Berger S, Grummt I, Schütz G.

J Neurosci. 2008 Nov 26;28(48):12759-64. doi: 10.1523/JNEUROSCI.2439-08.2008.


Translation in Saccharomyces cerevisiae: initiation factor 4A-dependent cell-free system.

Blum S, Mueller M, Schmid SR, Linder P, Trachsel H.

Proc Natl Acad Sci U S A. 1989 Aug;86(16):6043-6.


Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis.

Yuan X, Zhou Y, Casanova E, Chai M, Kiss E, Gröne HJ, Schütz G, Grummt I.

Mol Cell. 2005 Jul 1;19(1):77-87.

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