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Items: 1 to 20 of 93

1.

Metabolism of fluorine-containing drugs.

Park BK, Kitteringham NR, O'Neill PM.

Annu Rev Pharmacol Toxicol. 2001;41:443-70. Review.

PMID:
11264465
2.

Effects of fluorine substitution on drug metabolism: pharmacological and toxicological implications.

Park BK, Kitteringham NR.

Drug Metab Rev. 1994;26(3):605-43. Review. No abstract available.

PMID:
7924905
3.

The many roles for fluorine in medicinal chemistry.

Hagmann WK.

J Med Chem. 2008 Aug 14;51(15):4359-69. doi: 10.1021/jm800219f. Epub 2008 Jun 21. No abstract available.

PMID:
18570365
4.

Fluorine magnetic resonance in vivo: a powerful tool in the study of drug distribution and metabolism.

Reid DG, Murphy PS.

Drug Discov Today. 2008 Jun;13(11-12):473-80. doi: 10.1016/j.drudis.2007.12.011. Epub 2008 Mar 11. Review.

PMID:
18549972
5.

Potential explanation for fluorinated compounds' persistence.

Betts KS.

Environ Sci Technol. 2003 Sep 1;37(17):312A-313A. No abstract available.

PMID:
12967081
6.

Magnetic resonance spectroscopy for measuring the biodistribution and in situ in vivo pharmacokinetics of fluorinated compounds: validation using an investigation of liver and heart disposition of tecastemizole.

Schneider E, Bolo NR, Frederick B, Wilkinson S, Hirashima F, Nassar L, Lyoo IK, Koch P, Jones S, Hwang J, Sung Y, Villafuerte RA, Maier G, Hsu R, Hashoian R, Renshaw PF.

J Clin Pharm Ther. 2006 Jun;31(3):261-73.

PMID:
16789992
7.

Fluorinated molecules as drugs and imaging agents in the CNS.

Sun S, Adejare A.

Curr Top Med Chem. 2006;6(14):1457-64. Review.

PMID:
16918461
8.

Effect of selected fluorinated drugs in a "ringing" gel on rheological behaviour and skin permeation.

Höller S, Valenta C.

Eur J Pharm Biopharm. 2007 Apr;66(1):120-6. Epub 2006 Sep 10.

PMID:
17055710
9.

Biodegradation of polyfluorinated biphenyl in bacteria.

Hughes D, Clark BR, Murphy CD.

Biodegradation. 2011 Jul;22(4):741-9. doi: 10.1007/s10532-010-9411-7. Epub 2010 Sep 10.

PMID:
20830605
10.

Basic concepts in drug metabolism: Part II.

Jordan RA, Woolf TF.

J Clin Pharmacol. 1987 Feb;27(2):87-90. Review.

PMID:
3316305
11.

Role of phosphatidylserine binding in tissue distribution of amine-containing basic compounds.

Murakami T, Yumoto R.

Expert Opin Drug Metab Toxicol. 2011 Mar;7(3):353-64. doi: 10.1517/17425255.2011.548805. Review.

PMID:
21332386
12.

Magnetic resonance spectroscopy: a powerful tool for drug metabolism studies.

Malet-Martino MC, Martino R.

Biochimie. 1992 Sep-Oct;74(9-10):785-800. Review.

PMID:
1467338
13.

[Fluorine, an essential element for medicinal chemistry].

Bonnet-Delpon D.

Ann Pharm Fr. 2008 Jan;66(1):56-9. doi: 10.1016/j.pharma.2007.12.001. Epub 2008 Apr 2. French.

PMID:
18435988
14.

Metabolism of fluoroorganic compounds in microorganisms: impacts for the environment and the production of fine chemicals.

Murphy CD, Clark BR, Amadio J.

Appl Microbiol Biotechnol. 2009 Sep;84(4):617-29. doi: 10.1007/s00253-009-2127-0. Epub 2009 Jul 24. Review.

PMID:
19629474
15.

The complexities inherent in attempts to decrease drug clearance by blocking sites of CYP-mediated metabolism.

Fisher MB, Henne KR, Boer J.

Curr Opin Drug Discov Devel. 2006 Jan;9(1):101-9. Review.

PMID:
16445122
16.

Drugs--some basic concepts.

Sweeney GD.

Med Sci Sports Exerc. 1981;13(4):247-51.

PMID:
7278571
17.

Drug metabolism and pharmacokinetics in support of drug design.

Tang W, Lu AY.

Curr Pharm Des. 2009;15(19):2170-83. Review.

PMID:
19601821
18.

[Role of drug metabolism studies in the development of new drugs].

Kato R.

Nihon Yakurigaku Zasshi. 1993 Sep;102(3):245-52. Review. Japanese.

PMID:
8406235
19.

Fluorination of 3-(3-(piperidin-1-yl)propyl)indoles and 3-(3-(piperazin-1-yl)propyl)indoles gives selective human 5-HT1D receptor ligands with improved pharmacokinetic profiles.

van Niel MB, Collins I, Beer MS, Broughton HB, Cheng SK, Goodacre SC, Heald A, Locker KL, MacLeod AM, Morrison D, Moyes CR, O'Connor D, Pike A, Rowley M, Russell MG, Sohal B, Stanton JA, Thomas S, Verrier H, Watt AP, Castro JL.

J Med Chem. 1999 Jun 17;42(12):2087-104.

PMID:
10377215
20.

Alternate strategies to obtain mass balance without the use of radiolabeled compounds: application of quantitative fluorine (19F) nuclear magnetic resonance (NMR) spectroscopy in metabolism studies.

Mutlib A, Espina R, Atherton J, Wang J, Talaat R, Scatina J, Chandrasekaran A.

Chem Res Toxicol. 2012 Mar 19;25(3):572-83. doi: 10.1021/tx2005629. Epub 2012 Feb 10.

PMID:
22292524

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