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Items: 1 to 20 of 180

1.

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans.

Tissenbaum HA, Guarente L.

Nature. 2001 Mar 8;410(6825):227-30.

PMID:
11242085
2.

Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16.

Hashimoto T, Horikawa M, Nomura T, Sakamoto K.

Biogerontology. 2010 Feb;11(1):31-43. doi: 10.1007/s10522-009-9225-3. Epub 2009 Apr 16.

PMID:
19370397
3.

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase.

Imai S, Armstrong CM, Kaeberlein M, Guarente L.

Nature. 2000 Feb 17;403(6771):795-800.

PMID:
10693811
4.

Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration.

Lin SJ, Kaeberlein M, Andalis AA, Sturtz LA, Defossez PA, Culotta VC, Fink GR, Guarente L.

Nature. 2002 Jul 18;418(6895):344-8.

PMID:
12124627
5.
6.
7.

Ageing. Yeast longevity gene goes public.

Gems D.

Nature. 2001 Mar 8;410(6825):154-5. No abstract available.

PMID:
11258373
8.

C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span.

Berdichevsky A, Viswanathan M, Horvitz HR, Guarente L.

Cell. 2006 Jun 16;125(6):1165-77.

9.

C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO.

Wang Y, Oh SW, Deplancke B, Luo J, Walhout AJ, Tissenbaum HA.

Mech Ageing Dev. 2006 Sep;127(9):741-7. Epub 2006 Jul 24.

PMID:
16860373
10.

Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO.

Wang Y, Tissenbaum HA.

Mech Ageing Dev. 2006 Jan;127(1):48-56. Epub 2005 Nov 8.

PMID:
16280150
11.
12.

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila.

Burnett C, Valentini S, Cabreiro F, Goss M, Somogyvári M, Piper MD, Hoddinott M, Sutphin GL, Leko V, McElwee JJ, Vazquez-Manrique RP, Orfila AM, Ackerman D, Au C, Vinti G, Riesen M, Howard K, Neri C, Bedalov A, Kaeberlein M, Soti C, Partridge L, Gems D.

Nature. 2011 Sep 21;477(7365):482-5. doi: 10.1038/nature10296.

13.

The Caenorhabditis elegans nicotinamidase PNC-1 enhances survival.

van der Horst A, Schavemaker JM, Pellis-van Berkel W, Burgering BM.

Mech Ageing Dev. 2007 Apr;128(4):346-9. Epub 2007 Feb 2.

PMID:
17335870
14.

SIR2 and aging--the exception that proves the rule.

Guarente L.

Trends Genet. 2001 Jul;17(7):391-2.

PMID:
11418219
15.

Enzymatic activities of Sir2 and chromatin silencing.

Moazed D.

Curr Opin Cell Biol. 2001 Apr;13(2):232-8. Review.

PMID:
11248558
16.

Genetic pathways that regulate ageing in model organisms.

Guarente L, Kenyon C.

Nature. 2000 Nov 9;408(6809):255-62. Review.

PMID:
11089983
17.

The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases.

Landry J, Sutton A, Tafrov ST, Heller RC, Stebbins J, Pillus L, Sternglanz R.

Proc Natl Acad Sci U S A. 2000 May 23;97(11):5807-11.

18.

DhHP-6 extends lifespan of Caenorhabditis elegans by enhancing nuclear translocation and transcriptional activity of DAF-16.

Huang L, Li P, Wang G, Guan S, Sun X, Wang L.

Free Radic Res. 2013 Apr;47(4):316-24. doi: 10.3109/10715762.2013.773588. Epub 2013 Mar 8.

PMID:
23410029
19.

The Sir2 protein family: A novel deacetylase for gene silencing and more.

Shore D.

Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14030-2. Review. No abstract available.

20.

A systematic RNAi screen for longevity genes in C. elegans.

Hamilton B, Dong Y, Shindo M, Liu W, Odell I, Ruvkun G, Lee SS.

Genes Dev. 2005 Jul 1;19(13):1544-55.

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