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Items: 1 to 20 of 229

1.

Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli.

Pfeifer BA, Admiraal SJ, Gramajo H, Cane DE, Khosla C.

Science. 2001 Mar 2;291(5509):1790-2.

2.

Identification of a phosphopantetheinyl transferase for erythromycin biosynthesis in Saccharopolyspora erythraea.

Weissman KJ, Hong H, Oliynyk M, Siskos AP, Leadlay PF.

Chembiochem. 2004 Jan 3;5(1):116-25.

PMID:
14695521
3.

Engineered biosynthesis of a complete macrolactone in a heterologous host.

Kao CM, Katz L, Khosla C.

Science. 1994 Jul 22;265(5171):509-12.

PMID:
8036492
4.

Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivatives.

Ruan X, Pereda A, Stassi DL, Zeidner D, Summers RG, Jackson M, Shivakumar A, Kakavas S, Staver MJ, Donadio S, Katz L.

J Bacteriol. 1997 Oct;179(20):6416-25.

5.

Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage.

Cortes J, Wiesmann KE, Roberts GA, Brown MJ, Staunton J, Leadlay PF.

Science. 1995 Jun 9;268(5216):1487-9.

PMID:
7770773
6.

6-Deoxyerythronolide B synthase 3 from Saccharopolyspora erythraea: over-expression in Escherichia coli, purification and characterisation.

Roberts GA, Staunton J, Leadlay PF.

Biochem Soc Trans. 1993 Feb;21(1):32S. No abstract available.

PMID:
8449313
7.

Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production.

Murli S, Kennedy J, Dayem LC, Carney JR, Kealey JT.

J Ind Microbiol Biotechnol. 2003 Aug;30(8):500-9.

PMID:
12898389
8.

Microbiology. Possible new route to polyketide synthesis.

Ferber D.

Science. 2001 Mar 2;291(5509):1683. No abstract available.

PMID:
11253181
9.

A specific role of the Saccharopolyspora erythraea thioesterase II gene in the function of modular polyketide synthases.

Hu Z, Pfeifer BA, Chao E, Murli S, Kealey J, Carney JR, Ashley G, Khosla C, Hutchinson CR.

Microbiology. 2003 Aug;149(Pt 8):2213-25.

PMID:
12904561
10.

A new modular polyketide synthase in the erythromycin producer Saccharopolyspora erythraea.

Boakes S, Oliynyk M, Cortés J, Böhm I, Rudd BA, Revill WP, Staunton J, Leadlay PF.

J Mol Microbiol Biotechnol. 2004;8(2):73-80.

PMID:
15925898
11.

Production of the polyketide 6-deoxyerythronolide B in the heterologous host Bacillus subtilis.

Kumpfmüller J, Methling K, Fang L, Pfeifer BA, Lalk M, Schweder T.

Appl Microbiol Biotechnol. 2016 Feb;100(3):1209-20. doi: 10.1007/s00253-015-6990-6.

12.

Process and metabolic strategies for improved production of Escherichia coli-derived 6-deoxyerythronolide B.

Pfeifer B, Hu Z, Licari P, Khosla C.

Appl Environ Microbiol. 2002 Jul;68(7):3287-92.

13.

The loading domain of the erythromycin polyketide synthase is not essential for erythromycin biosynthesis in Saccharopolyspora erythraea.

Pereda A, Summers RG, Stassi DL, Ruan X, Katz L.

Microbiology. 1998 Feb;144 ( Pt 2):543-53.

PMID:
9493390
14.

Engineering broader specificity into an antibiotic-producing polyketide synthase.

Marsden AF, Wilkinson B, Cortés J, Dunster NJ, Staunton J, Leadlay PF.

Science. 1998 Jan 9;279(5348):199-202.

15.

Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase.

Jacobsen JR, Hutchinson CR, Cane DE, Khosla C.

Science. 1997 Jul 18;277(5324):367-9.

16.

Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase.

Wilkinson B, Foster G, Rudd BA, Taylor NL, Blackaby AP, Sidebottom PJ, Cooper DJ, Dawson MJ, Buss AD, Gaisser S, Böhm IU, Rowe CJ, Cortés J, Leadlay PF, Staunton J.

Chem Biol. 2000 Feb;7(2):111-7.

17.

Rapid engineering of polyketide overproduction by gene transfer to industrially optimized strains.

Rodriguez E, Hu Z, Ou S, Volchegursky Y, Hutchinson CR, McDaniel R.

J Ind Microbiol Biotechnol. 2003 Aug;30(8):480-8.

PMID:
12698320
18.
19.

Saccharopolyspora erythraea-catalyzed bioconversion of 6-deoxyerythronolide B analogs for production of novel erythromycins.

Carreras C, Frykman S, Ou S, Cadapan L, Zavala S, Woo E, Leaf T, Carney J, Burlingame M, Patel S, Ashley G, Licari P.

J Biotechnol. 2002 Jan 18;92(3):217-28.

PMID:
11689246
20.

An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea.

Cortes J, Haydock SF, Roberts GA, Bevitt DJ, Leadlay PF.

Nature. 1990 Nov 8;348(6297):176-8.

PMID:
2234082
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