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Items: 1 to 20 of 202

1.

A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes.

Mauvais-Jarvis F, Virkamaki A, Michael MD, Winnay JN, Zisman A, Kulkarni RN, Kahn CR.

Diabetes. 2000 Dec;49(12):2126-34.

PMID:
11118016
2.

Insulin resistance causes increased beta-cell mass but defective glucose-stimulated insulin secretion in a murine model of type 2 diabetes.

Asghar Z, Yau D, Chan F, Leroith D, Chan CB, Wheeler MB.

Diabetologia. 2006 Jan;49(1):90-9. Epub 2005 Dec 15. Erratum in: Diabetologia. 2006 Mar;49(3):614.

PMID:
16362284
3.

Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease.

Terauchi Y, Iwamoto K, Tamemoto H, Komeda K, Ishii C, Kanazawa Y, Asanuma N, Aizawa T, Akanuma Y, Yasuda K, Kodama T, Tobe K, Yazaki Y, Kadowaki T.

J Clin Invest. 1997 Mar 1;99(5):861-6.

4.

Characterization of insulin resistance and NIDDM in transgenic mice with reduced brown fat.

Hamann A, Benecke H, Le Marchand-Brustel Y, Susulic VS, Lowell BB, Flier JS.

Diabetes. 1995 Nov;44(11):1266-73.

PMID:
7589822
5.

Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue.

Lauro D, Kido Y, Castle AL, Zarnowski MJ, Hayashi H, Ebina Y, Accili D.

Nat Genet. 1998 Nov;20(3):294-8.

PMID:
9806552
6.

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

Kido Y, Burks DJ, Withers D, Bruning JC, Kahn CR, White MF, Accili D.

J Clin Invest. 2000 Jan;105(2):199-205.

7.

K(ATP) channel knockout mice crossbred with transgenic mice expressing a dominant-negative form of human insulin receptor have glucose intolerance but not diabetes.

Kanezaki Y, Obata T, Matsushima R, Minami A, Yuasa T, Kishi K, Bando Y, Uehara H, Izumi K, Mitani T, Matsumoto M, Takeshita Y, Nakaya Y, Matsumoto T, Ebina Y.

Endocr J. 2004 Apr;51(2):133-44.

8.
9.

Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance.

Mauvais-Jarvis F, Kulkarni RN, Kahn CR.

Clin Endocrinol (Oxf). 2002 Jul;57(1):1-9. Review.

PMID:
12100063
10.

GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes.

Stenbit AE, Tsao TS, Li J, Burcelin R, Geenen DL, Factor SM, Houseknecht K, Katz EB, Charron MJ.

Nat Med. 1997 Oct;3(10):1096-101.

PMID:
9334720
11.

A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance.

Brüning JC, Michael MD, Winnay JN, Hayashi T, Hörsch D, Accili D, Goodyear LJ, Kahn CR.

Mol Cell. 1998 Nov;2(5):559-69.

12.

Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle.

Carvalho E, Kotani K, Peroni OD, Kahn BB.

Am J Physiol Endocrinol Metab. 2005 Oct;289(4):E551-61. Epub 2005 May 31.

13.

A1 receptor deficiency causes increased insulin and glucagon secretion in mice.

Johansson SM, Salehi A, Sandström ME, Westerblad H, Lundquist I, Carlsson PO, Fredholm BB, Katz A.

Biochem Pharmacol. 2007 Dec 3;74(11):1628-35. Epub 2007 Aug 9.

PMID:
17869224
14.

Beta-cell secretory dysfunction in the pathogenesis of low birth weight-associated diabetes: a murine model.

Jimenez-Chillaron JC, Hernandez-Valencia M, Reamer C, Fisher S, Joszi A, Hirshman M, Oge A, Walrond S, Przybyla R, Boozer C, Goodyear LJ, Patti ME.

Diabetes. 2005 Mar;54(3):702-11.

15.
16.

Implications of blood glucose, insulin resistance and beta-cell function in impaired glucose tolerance.

Göke B.

Diabetes Res Clin Pract. 1998 Jul;40 Suppl:S15-20. Review.

PMID:
9740497
17.

Severe insulin-resistant diabetes mellitus in patients with congenital muscle fiber type disproportion myopathy.

Vestergaard H, Klein HH, Hansen T, Müller J, Skovby F, Bjørbaek C, Røder ME, Pedersen O.

J Clin Invest. 1995 Apr;95(4):1925-32.

18.

Molecular insights into insulin action and secretion.

Rhodes CJ, White MF.

Eur J Clin Invest. 2002 Jun;32 Suppl 3:3-13. Review.

PMID:
12028370
19.
20.

5-Aminoimidazole-4-carboxamide ribonucleoside treatment improves glucose homeostasis in insulin-resistant diabetic (ob/ob) mice.

Song XM, Fiedler M, Galuska D, Ryder JW, Fernström M, Chibalin AV, Wallberg-Henriksson H, Zierath JR.

Diabetologia. 2002 Jan;45(1):56-65.

PMID:
11845224

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