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Items: 1 to 20 of 97

1.

Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord.

Tesseur I, Van Dorpe J, Bruynseels K, Bronfman F, Sciot R, Van Lommel A, Van Leuven F.

Am J Pathol. 2000 Nov;157(5):1495-510.

2.

Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice.

Tesseur I, Van Dorpe J, Spittaels K, Van den Haute C, Moechars D, Van Leuven F.

Am J Pathol. 2000 Mar;156(3):951-64.

3.

Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.

Brecht WJ, Harris FM, Chang S, Tesseur I, Yu GQ, Xu Q, Dee Fish J, Wyss-Coray T, Buttini M, Mucke L, Mahley RW, Huang Y.

J Neurosci. 2004 Mar 10;24(10):2527-34.

4.

Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein.

Spittaels K, Van den Haute C, Van Dorpe J, Bruynseels K, Vandezande K, Laenen I, Geerts H, Mercken M, Sciot R, Van Lommel A, Loos R, Van Leuven F.

Am J Pathol. 1999 Dec;155(6):2153-65.

5.

Modeling Alzheimer's disease in transgenic mice: effect of age and of presenilin1 on amyloid biochemistry and pathology in APP/London mice.

Dewachter I, van Dorpe J, Spittaels K, Tesseur I, Van Den Haute C, Moechars D, Van Leuven F.

Exp Gerontol. 2000 Sep;35(6-7):831-41. Review.

PMID:
11053674
6.

Characterization of transgenic mice expressing apolipoprotein E4(C112R) and apolipoprotein E4(L28P; C112R).

Huber G, März W, Martin JR, Malherbe P, Richards JG, Sueoka N, Ohm T, Hoffmann MM.

Neuroscience. 2000;101(1):211-8.

PMID:
11068149
7.
8.

Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice.

Xu PT, Schmechel D, Rothrock-Christian T, Burkhart DS, Qiu HL, Popko B, Sullivan P, Maeda N, Saunders AM, Roses AD, Gilbert JR.

Neurobiol Dis. 1996;3(3):229-45.

PMID:
8980023
9.

Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform.

Ishihara T, Hong M, Zhang B, Nakagawa Y, Lee MK, Trojanowski JQ, Lee VM.

Neuron. 1999 Nov;24(3):751-62.

10.

Neuronal or glial expression of human apolipoprotein e4 affects parenchymal and vascular amyloid pathology differentially in different brain regions of double- and triple-transgenic mice.

Van Dooren T, Muyllaert D, Borghgraef P, Cresens A, Devijver H, Van der Auwera I, Wera S, Dewachter I, Van Leuven F.

Am J Pathol. 2006 Jan;168(1):245-60.

11.

Human apolipoprotein E allele-specific brain expressing transgenic mice.

Smith JD, Sikes J, Levin JA.

Neurobiol Aging. 1998 Sep-Oct;19(5):407-13.

PMID:
9880043
12.

Human apoE3 but not apoE4 rescues impaired astrocyte activation in apoE null mice.

Ophir G, Meilin S, Efrati M, Chapman J, Karussis D, Roses A, Michaelson DM.

Neurobiol Dis. 2003 Feb;12(1):56-64.

PMID:
12609489
13.
14.

Ultrastructural neuronal pathology in transgenic mice expressing mutant (P301L) human tau.

Lin WL, Lewis J, Yen SH, Hutton M, Dickson DW.

J Neurocytol. 2003 Nov;32(9):1091-105.

PMID:
15044841
16.

Effect of domain interaction on apolipoprotein E levels in mouse brain.

Ramaswamy G, Xu Q, Huang Y, Weisgraber KH.

J Neurosci. 2005 Nov 16;25(46):10658-63.

17.

Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models.

Huang Y.

Biochem Soc Trans. 2011 Aug;39(4):924-32. doi: 10.1042/BST0390924.

PMID:
21787325
18.

Generation and characterization of two transgenic mouse lines expressing human ApoE2 in neurons and glial cells.

Georgopoulos S, McKee A, Kan HY, Zannis VI.

Biochemistry. 2002 Jul 30;41(30):9293-301.

PMID:
12135350
19.

Susceptibility of transgenic mice expressing human apolipoprotein E to closed head injury: the allele E3 is neuroprotective whereas E4 increases fatalities.

Sabo T, Lomnitski L, Nyska A, Beni S, Maronpot RR, Shohami E, Roses AD, Michaelson DM.

Neuroscience. 2000;101(4):879-84.

PMID:
11113336
20.

Possible role of tau in mediating pathological effects of apoE4 in vivo prior to and following activation of the amyloid cascade.

Inbar D, Belinson H, Rosenman H, Michaelson DM.

Neurodegener Dis. 2010;7(1-3):16-23. doi: 10.1159/000283477.

PMID:
20160452
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